Mxi1 MGI Mouse Gene Detail - MGI:97245 - MAX interactor 1, dimerization protein

Symbol

Mxi1
Name

MAX interactor 1, dimerization protein
Synonyms

bHLHc11, Mad2

Feature Type

protein coding gene
IDs

MGI:97245
NCBI Gene: 17859
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr19:53298509-53361724 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 47.53 cM, cytoband D
Mapping Data

11 experiments

SNPs within 2kb

1781 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97245	protein coding gene	Chr19:53298509-53364241 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025244	protein coding gene	Chr19:53451204-53526410 (+)
A/J	MGP_AJ_G0025220	protein coding gene	Chr19:50800197-50875105 (+)
AKR/J	MGP_AKRJ_G0025189	protein coding gene	Chr19:52404663-52474993 (+)
BALB/cJ	MGP_BALBcJ_G0025215	protein coding gene	Chr19:50893684-50958870 (+)
C3H/HeJ	MGP_C3HHeJ_G0024975	protein coding gene	Chr19:52621168-52691635 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025658	protein coding gene	Chr19:54735642-54803845 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023070	protein coding gene	Chr19:49808906-49873913 (+)
CAST/EiJ	MGP_CASTEiJ_G0024440	protein coding gene	Chr19:52573334-52648265 (+)
CBA/J	MGP_CBAJ_G0024955	protein coding gene	Chr19:57424458-57513324 (+)
DBA/2J	MGP_DBA2J_G0025087	protein coding gene	Chr19:50611324-50677472 (+)
FVB/NJ	MGP_FVBNJ_G0025048	protein coding gene	Chr19:50322059-50389251 (+)
LP/J	MGP_LPJ_G0025173	protein coding gene	Chr19:53301799-53375616 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025079	protein coding gene	Chr19:56884634-56959137 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025716	protein coding gene	Chr19:52598808-52667842 (+)
PWK/PhJ	MGP_PWKPhJ_G0024188	protein coding gene	Chr19:50528352-50595857 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023991	protein coding gene	Chr19:51280603-51353095 (+)
WSB/EiJ	MGP_WSBEiJ_G0024510	protein coding gene	Chr19:52733076-52798757 (+)

Human Ortholog

MXI1, MAX interactor 1, dimerization protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MXI1, MAX interactor 1, dimerization protein
Synonyms

bHLHc11, MAD2, MXD2, MXI
Links

HGNC:7534

NCBI Gene ID: 4601

neXtProt AC: NX_P50539

UniProt: P50539
Chr Location

10q25.2; chr10:110207605-110287365 (+) GRCh38

MGI Vertebrate Homology

Mxi1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MXI1
Gene Tree

Mxi1

Diseases

2 with human MXI1 associations

				Human Disease	Mouse Models
				neurofibrosarcoma IDs neurofibrosarcoma DOID:3512 MESH:D018319 UMLS_CUI:C0206729
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Endonuclease-mediated

3
Gene trapped

18
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show multisystem anomalies including progressive hyperplasia in the spleen and prostate, degenerative changes in the kidney, and increased sensitivity to carcinogens. In addition, mutant embryo fibroblasts are more prone to transformation by the Myc and Ras oncogenes.

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All GO Annotations

17
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1042
Tissues

286
cDNA Data

101
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MXI1

Xenbase mxi1

ZFIN mxi1

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All Sequences

85
RefSeq

24
UniProt

6
CCDS

CCDS29901.1, CCDS38022.1, CCDS38023.1

Ensembl

ENSMUSG00000025025 (Evidence)
NCBI Gene

17859

			Length	Strain/Species	Flank
genomic	17859	NCBI Gene Model \| MGI Sequence Detail	63216	C57BL/6J	± kb
transcript	NM_001008542	RefSeq \| MGI Sequence Detail	2639	ZRU/MplStud
polypeptide	P50540	UniProt \| EBI \| MGI Sequence Detail	228	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000010793 max-interacting protein 1

(term hierarchy)
InterPro Domains

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

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All nucleic 111

Genomic 1

cDNA 103

Primer pair 5

Other 2

Microarray probesets 4

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MGD-MRK-12730

Summaries

All 74

Developmental Gene Expression 16

Gene Ontology 8

Phenotypes 12
Earliest

J:16599 Edelhoff S, et al., Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19. Oncogene. 1994 Feb;9(2):665-8
Latest

J:306925 Menendez-Montes I, et al., Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice. iScience. 2021 Feb 19;24(2):102124

TSS for Mxi1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156965	Chr19:53298851-53298878 (+)	356 bp
Tssr156966	Chr19:53298889-53298894 (+)	383 bp
Tssr156967	Chr19:53298906-53298925 (+)	407 bp
Tssr156968	Chr19:53298926-53298983 (+)	446 bp
Tssr156969	Chr19:53299001-53299010 (+)	497 bp
Tssr156970	Chr19:53299289-53299302 (+)	787 bp
Tssr156971	Chr19:53299806-53299822 (+)	1,305 bp
Tssr156972	Chr19:53301855-53301866 (+)	3,352 bp
Tssr5550	Chr19:53307695-53307697 (+)	9,187 bp
Tssr156973	Chr19:53317855-53317909 (+)	19,373 bp
Tssr156974	Chr19:53317938-53317949 (+)	19,435 bp
Tssr156975	Chr19:53341318-53341324 (+)	42,812 bp
Tssr156976	Chr19:53345674-53345683 (+)	47,170 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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