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Myf6 Gene Detail
Summary
  • Symbol
    Myf6
  • Name
    myogenic factor 6
  • Synonyms
    bHLHc4, herculin, MRF4
  • Feature Type
    protein coding gene
  • IDs
    MGI:97253
    NCBI Gene: 17878
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:107328709-107330584 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 55.96 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97253
 protein coding gene Chr10:107328709-107330598 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017709
 protein coding gene Chr10:109688592-109692818 (-)
A/J MGP_AJ_G0017686
 protein coding gene Chr10:105579312-105581146 (-)
AKR/J MGP_AKRJ_G0017648
 protein coding gene Chr10:108645920-108647769 (-)
BALB/cJ MGP_BALBcJ_G0017650
 protein coding gene Chr10:105969116-105971315 (-)
C3H/HeJ MGP_C3HHeJ_G0017475
 protein coding gene Chr10:108747703-108749532 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018107
 protein coding gene Chr10:113486938-113489285 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015786
 protein coding gene Chr10:100498134-100499938 (-)
CAST/EiJ MGP_CASTEiJ_G0017036
 protein coding gene Chr10:108847853-108849705 (-)
CBA/J MGP_CBAJ_G0017444
 protein coding gene Chr10:117906365-117910693 (-)
DBA/2J MGP_DBA2J_G0017549
 protein coding gene Chr10:104720665-104722493 (-)
FVB/NJ MGP_FVBNJ_G0017543
 protein coding gene Chr10:103716389-103718258 (-)
LP/J MGP_LPJ_G0017623
 protein coding gene Chr10:110306903-110308729 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017572
 protein coding gene Chr10:120425153-120427857 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018145
 protein coding gene Chr10:108636461-108638266 (-)
PWK/PhJ MGP_PWKPhJ_G0016818
 protein coding gene Chr10:104773124-104774925 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016608
 protein coding gene Chr10:107383454-107385304 (-)
WSB/EiJ MGP_WSBEiJ_G0017096
 protein coding gene Chr10:108749663-108751540 (-)



Homology
more
  • Human Ortholog
    MYF6, myogenic factor 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYF6, myogenic factor 6
  • Synonyms
    bHLHc4, CNM3, MRF4, myf-6
  • Links
    NCBI Gene ID: 4618
    neXtProt AC: NX_P23409
    UniProt: P23409

  • Chr Location
    12q21.31; chr12:80707634-80709474 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MYF6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 4 genetic backgrounds
    35 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations exhibit variable rib abnormalities, abnormal intercostal muscle morphology, reduced expression of Myf5, and postnatal mortality proportional to the severity of the rib defect.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1146
  • Tissues
    210
  • cDNA Data
    11
  • Literature Summary
    76
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17878 NCBI Gene Model | MGI Sequence Detail 1876 C57BL/6J ±  kb
    transcript NM_008657 RefSeq | MGI Sequence Detail 1254 ZRU/MplStud  
    polypeptide P15375 UniProt | EBI | MGI Sequence Detail 242 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 13
      cDNA 16
      Primer pair 15
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12739
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 76
      Diseases 1
      Gene Ontology 13
      Phenotypes 46
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:330271 Tekko T, et al., Assessing Myf5 and Lbx1 contribution to carapace development by reproducing their turtle-specific signatures in mouse embryos. Dev Dyn. 2022 Oct;251(10):1698-1710
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory