Myl4 MGI Mouse Gene Detail - MGI:97267 - myosin, light polypeptide 4

Symbol

Myl4
Name

myosin, light polypeptide 4
Synonyms

ELC, ELC1a, MLC1a, Myla

Feature Type

protein coding gene
IDs

MGI:97267
NCBI Gene: 17896
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr11:104441489-104486579 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 67.79 cM, cytoband E
Mapping Data

17 experiments

SNPs within 2kb

1459 from dbSNP Build 142
Strain Annotations

18
PCR

5
RFLP

9

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97267	protein coding gene	Chr11:104427604-104486579 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019277	protein coding gene	Chr11:107709646-107767424 (+)
A/J	MGP_AJ_G0019245	protein coding gene	Chr11:103130679-103177133 (+)
AKR/J	MGP_AKRJ_G0019214	protein coding gene	Chr11:106275506-106327559 (+)
BALB/cJ	MGP_BALBcJ_G0019219	protein coding gene	Chr11:103562286-103610807 (+)
C3H/HeJ	MGP_C3HHeJ_G0019028	protein coding gene	Chr11:106518655-106566432 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019669	protein coding gene	Chr11:111067539-111095647 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017294	protein coding gene	Chr11:100520111-100562915 (+)
CAST/EiJ	MGP_CASTEiJ_G0018582	protein coding gene	Chr11:107579367-107620282 (+)
CBA/J	MGP_CBAJ_G0018997	protein coding gene	Chr11:115643929-115701805 (+)
DBA/2J	MGP_DBA2J_G0019109	protein coding gene	Chr11:102616697-102662262 (+)
FVB/NJ	MGP_FVBNJ_G0019100	protein coding gene	Chr11:102154187-102205427 (+)
LP/J	MGP_LPJ_G0019178	protein coding gene	Chr11:108186000-108233801 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019130	protein coding gene	Chr11:114962803-115011238 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019706	protein coding gene	Chr11:106678805-106727692 (+)
PWK/PhJ	MGP_PWKPhJ_G0018347	protein coding gene	Chr11:103722284-103758007 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018137	protein coding gene	Chr11:106450379-106519410 (+)
WSB/EiJ	MGP_WSBEiJ_G0018631	protein coding gene	Chr11:106690054-106739422 (+)

Human Ortholog

MYL4, myosin light chain 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYL4, myosin light chain 4
Synonyms

ALC1, AMLC, GT1, PRO1957
Links

HGNC:7585

NCBI Gene ID: 4635

neXtProt AC: NX_P12829

UniProt: P12829
Chr Location

17q21.32; chr17:47189433-47227650 (+) GRCh38

MGI Vertebrate Homology

Myl4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MYL4
Gene Tree

Myl4

Diseases

2 with human MYL4 associations

				Human Disease	Mouse Models
				cardiomyopathy IDs cardiomyopathy DOID:0050700 ICD10CM:I42 ICD9CM:425 ICD9CM:425.9 MESH:D009202 NCI:C34830 NCI:C53654 UMLS_CUI:C0033141 UMLS_CUI:C0036529 UMLS_CUI:C0878544
				familial atrial fibrillation IDs familial atrial fibrillation DOID:0050650 OMIM:607554 OMIM:608583 OMIM:608988 OMIM:611493 OMIM:611494 OMIM:612201 OMIM:612240 OMIM:613055 OMIM:613980 OMIM:614022 OMIM:614049 OMIM:614050 OMIM:615377 OMIM:615378 OMIM:615770 OMIM:PS608583 ORDO:334

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Endonuclease-mediated

1
Gene trapped

22
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1108
Tissues

129
cDNA Data

117
Literature Summary

45

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase myl4

ZFIN myl4

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All Sequences

73
RefSeq

18
UniProt

5
CCDS

CCDS25535.1

Ensembl

ENSMUSG00000061086 (Evidence)
NCBI Gene

17896

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061086	Ensembl Gene Model \| MGI Sequence Detail	45091	C57BL/6J	± kb
transcript	ENSMUST00000018800	Ensembl \| MGI Sequence Detail	879	Not Applicable
polypeptide	ENSMUSP00000018800	Ensembl \| MGI Sequence Detail	193	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010836 myosin light chain 4

(term hierarchy)
InterPro Domains

IPR050230 Calcium-Regulated Muscle Contraction and Cellular Process

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair
GlyGen

P09541 1 site, 1 O-linked glycan (1 site)

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All nucleic 138

Genomic 4

cDNA 118

Primer pair 6

Other 10

Microarray probesets 4

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MGD-MRK-12765

Summaries

All 111

Developmental Gene Expression 45

Gene Ontology 4

Phenotypes 9
Earliest

J:35864 Lowey S, et al., Light chains from fast and slow muscle myosins. Nature. 1971 Nov 12;234(5324):81-5
Latest

J:354224 Van Wauwe J, et al., PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates. Life Sci Alliance. 2024 Dec;7(12)

TSS for Myl4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105394	Chr11:104440951-104440978 (+)	-524 bp
Tssr105395	Chr11:104441508-104441511 (+)	21 bp
Tssr105396	Chr11:104441514-104441525 (+)	31 bp
Tssr105397	Chr11:104441609-104441618 (+)	125 bp
Tssr105399	Chr11:104467791-104467804 (+)	26,309 bp
Tssr105400	Chr11:104467829-104467848 (+)	26,350 bp
Tssr105401	Chr11:104467873-104467880 (+)	26,388 bp
Tssr105402	Chr11:104468193-104468213 (+)	26,714 bp
Tssr105403	Chr11:104471198-104471209 (+)	29,715 bp
Tssr105404	Chr11:104472465-104472512 (+)	31,000 bp
Tssr105405	Chr11:104472919-104472933 (+)	31,437 bp
Tssr105406	Chr11:104473701-104473725 (+)	32,224 bp
Tssr105407	Chr11:104475121-104475136 (+)	33,640 bp
Tssr105408	Chr11:104477108-104477122 (+)	35,626 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24