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Nat1 Gene Detail
Summary
  • Symbol
    Nat1
  • Name
    N-acetyl transferase 1
  • Synonyms
    Nat-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97279
    NCBI Gene: 17960
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:67943620-67945183 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 33.38 cM, cytoband B3.1
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97279
 protein coding gene Chr8:67933573-67945183 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033656
 protein coding gene Chr8:67585985-67587331 (+)
A/J MGP_AJ_G0033638
 protein coding gene Chr8:64864235-64865581 (+)
AKR/J MGP_AKRJ_G0033563
 protein coding gene Chr8:66596792-66598138 (+)
BALB/cJ MGP_BALBcJ_G0033634
 protein coding gene Chr8:65041813-65043159 (+)
C3H/HeJ MGP_C3HHeJ_G0033344
 protein coding gene Chr8:67356825-67358171 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034151
 protein coding gene Chr8:70127442-70128788 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031098
 protein coding gene Chr8:59795025-59796371 (+)
CAST/EiJ MGP_CASTEiJ_G0032669
 protein coding gene Chr8:66781130-66782476 (+)
CBA/J MGP_CBAJ_G0033322
 protein coding gene Chr8:72759918-72761264 (+)
DBA/2J MGP_DBA2J_G0033476
 protein coding gene Chr8:64570970-64572316 (+)
FVB/NJ MGP_FVBNJ_G0033417
 protein coding gene Chr8:63748093-63749439 (+)
LP/J MGP_LPJ_G0033564
 protein coding gene Chr8:67683473-67684819 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033461
 protein coding gene Chr8:75416741-75418087 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034169
 protein coding gene Chr8:66914979-66916325 (+)
PWK/PhJ MGP_PWKPhJ_G0032378
 protein coding gene Chr8:63837484-63838830 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032214
 protein coding gene Chr8:65810734-65812080 (+)
WSB/EiJ MGP_WSBEiJ_G0032786
 protein coding gene Chr8:67285242-67286588 (+)



Homology
more
  • Human Ortholog
    NAT1, N-acetyltransferase 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAT1, N-acetyltransferase 1
  • Synonyms
    AAC1, MNAT, NAT-1, NATI
  • Links
    NCBI Gene ID: 9
    neXtProt AC: NX_P18440
    UniProt: P18440

  • Chr Location
    8p22; chr8:18170467-18223689 (+)  GRCh38
  • Human Ortholog
    NAT2, N-acetyltransferase 2
  • Synonyms
    AAC2, NAT-2, PNAT
  • Links
    NCBI Gene ID: 10
    neXtProt AC: NX_P11245
    UniProt: P11245

  • Chr Location
    8p22; chr8:18386301-18401218 (+)  GRCh38
Human Diseases
more
  • Diseases
    29 with human NAT1,NAT2 associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit reduced fertility and a significant reduction in hepatic N-acetyltransferase 1 activity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    5
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    121
  • cDNA Data
    5
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17960 NCBI Gene Model | MGI Sequence Detail 1564 C57BL/6J ±  kb
    transcript NM_008673 RefSeq | MGI Sequence Detail 1564 ZRU/MplStud  
    polypeptide P50294 UniProt | EBI | MGI Sequence Detail 290 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 8
      cDNA 5
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-12778, MGD-MRK-12780
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:6685 Glowinski IB, et al., Genetic regulation of aromatic amine N-acetylation in inbred mice. J Biol Chem. 1982 Feb 10;257(3):1424-30
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory