Ncl MGI Mouse Gene Detail - MGI:97286

Symbol

Ncl
Name

nucleolin
Synonyms

B530004O11Rik, C23

Feature Type

protein coding gene
IDs

MGI:97286
NCBI Gene: 17975
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr1:86272441-86287122 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 43.94 cM
Mapping Data

6 experiments

SNPs within 2kb

346 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97286	protein coding gene	Chr1:86272441-86287177 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016246	protein coding gene	Chr1:87598805-87613455 (-)
A/J	MGP_AJ_G0016227	protein coding gene	Chr1:84354941-84369596 (-)
AKR/J	MGP_AKRJ_G0016188	protein coding gene	Chr1:86816300-86834362 (-)
BALB/cJ	MGP_BALBcJ_G0016184	protein coding gene	Chr1:84472588-84488681 (-)
C3H/HeJ	MGP_C3HHeJ_G0016012	protein coding gene	Chr1:87052919-87067603 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016640	protein coding gene	Chr1:90939536-90954212 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014362	protein coding gene	Chr1:78849383-78864356 (-)
CAST/EiJ	MGP_CASTEiJ_G0015597	protein coding gene	Chr1:86299025-86313676 (-)
CBA/J	MGP_CBAJ_G0015988	protein coding gene	Chr1:93761602-93780329 (-)
DBA/2J	MGP_DBA2J_G0016091	protein coding gene	Chr1:83663334-83677990 (-)
FVB/NJ	MGP_FVBNJ_G0016090	protein coding gene	Chr1:82720892-82735622 (-)
LP/J	MGP_LPJ_G0016162	protein coding gene	Chr1:88703062-88717722 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016116	protein coding gene	Chr1:97032697-97048108 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016683	protein coding gene	Chr1:86933998-86948663 (-)
PWK/PhJ	MGP_PWKPhJ_G0015384	protein coding gene	Chr1:82950107-82964932 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015164	protein coding gene	Chr1:85891319-85907939 (-)
WSB/EiJ	MGP_WSBEiJ_G0015661	protein coding gene	Chr1:86578515-86593159 (-)

Human Ortholog

NCL, nucleolin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NCL, nucleolin
Synonyms

C23, Nsr1
Links

HGNC:7667

NCBI Gene ID: 4691

neXtProt AC: NX_P19338

UniProt: P19338
Chr Location

2q37.1; chr2:231453531-231483641 (-) GRCh38

MGI Vertebrate Homology

Ncl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NCL
Gene Tree

Ncl

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Phenotype Summary

2 phenotypes from 1 allele in 3 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

59
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

53
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Ncl
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available

Mice homozygous for a null allele exhibit complete preweaning lethality while cultured neurons from heterozygotes exhibit accelerated axonal outgrowth.

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All GO Annotations

72
GO References

27

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

813
Tissues

68
cDNA Data

35
Literature Summary

17

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ncl

ZFIN ncl

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All Sequences

73
RefSeq

4
UniProt

8
CCDS

CCDS35646.1

Ensembl

ENSMUSG00000026234 (Evidence)
NCBI Gene

17975

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026234	Ensembl Gene Model \| MGI Sequence Detail	14682	C57BL/6J	± kb
transcript	ENSMUST00000027438	Ensembl \| MGI Sequence Detail	8202	Not Applicable
polypeptide	ENSMUSP00000027438	Ensembl \| MGI Sequence Detail	707	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000011038 nucleolin

(term hierarchy)
InterPro Domains

IPR034230 Nucleolin, RNA recognition motif 1

IPR034233 Nucleolin, RNA recognition motif 2

IPR034234 Nucleolin, RNA recognition motif 3

IPR034235 Nucleolin, RNA recognition motif 4

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR050441 RNA-binding motif

IPR000504 RNA recognition motif domain
GlyGen

P09405 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 42

Genomic 1

cDNA 36

Primer pair 5

Microarray probesets 8

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MGD-MRK-12795, MGD-MRK-12950, MGD-MRK-2398, MGD-MRK-5693, MGI:2442525

Summaries

All 105

Developmental Gene Expression 17

Gene Ontology 27

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:341993 Bernheim S, et al., Identification of Greb1l as a genetic determinant of crisscross heart in mice showing torsion of the heart tube by shortage of progenitor cells. Dev Cell. 2023 Oct 13;

TSS for Ncl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12792	Chr1:86287673-86287688 (-)	-559 bp
Tssr12791	Chr1:86287203-86287208 (-)	-84 bp
Tssr12790	Chr1:86287080-86287103 (-)	30 bp
Tssr12789	Chr1:86286740-86286768 (-)	368 bp
Tssr12788	Chr1:86286692-86286719 (-)	416 bp
Tssr12787	Chr1:86286198-86286203 (-)	921 bp
Tssr12786	Chr1:86285933-86285954 (-)	1,178 bp
Tssr12773	Chr1:86283901-86283920 (-)	3,211 bp
Tssr12768	Chr1:86278751-86278759 (-)	8,367 bp
Tssr12767	Chr1:86275736-86275740 (-)	11,384 bp
Tssr141	Chr1:86275361-86275396 (-)	11,743 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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