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Ndn Gene Detail
Summary
  • Symbol
    Ndn
  • Name
    necdin, MAGE family member
  • Synonyms
    Peg6
  • Feature Type
    protein coding gene
  • IDs
    MGI:97290
    NCBI Gene: 17984
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:61998025-61999676 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 34.36 cM, cytoband C
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97290
 protein coding gene Chr7:61996317-62000010 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032326
 protein coding gene Chr7:63428966-63430617 (+)
A/J MGP_AJ_G0032305
 protein coding gene Chr7:62223572-62225223 (+)
AKR/J MGP_AKRJ_G0032241
 protein coding gene Chr7:63544455-63546106 (+)
BALB/cJ MGP_BALBcJ_G0032317
 protein coding gene Chr7:61902899-61904550 (+)
C3H/HeJ MGP_C3HHeJ_G0032030
 protein coding gene Chr7:64151693-64153344 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032810
 protein coding gene Chr7:66191116-66192767 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029817
 protein coding gene Chr7:65255098-65256757 (+)
CAST/EiJ MGP_CASTEiJ_G0031359
 protein coding gene Chr7:54931058-54932709 (+)
CBA/J MGP_CBAJ_G0031996
 protein coding gene Chr7:68320790-68322441 (+)
DBA/2J MGP_DBA2J_G0032152
 protein coding gene Chr7:61049829-61051480 (+)
FVB/NJ MGP_FVBNJ_G0032106
 protein coding gene Chr7:61097118-61098769 (+)
LP/J MGP_LPJ_G0032233
 protein coding gene Chr7:64624430-64626081 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032143
 protein coding gene Chr7:68556088-68557739 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032827
 protein coding gene Chr7:62813063-62814714 (+)
PWK/PhJ MGP_PWKPhJ_G0031079
 protein coding gene Chr7:54026100-54027751 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030920
 protein coding gene Chr7:49937111-49938767 (+)
WSB/EiJ MGP_WSBEiJ_G0031477
 protein coding gene Chr7:63186361-63188012 (+)



Homology
more
  • Human Ortholog
    NDN, necdin, MAGE family member
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDN, necdin, MAGE family member
  • Synonyms
    HsT16328, PWCR
  • Links
    NCBI Gene ID: 4692
    neXtProt AC: NX_Q99608
    UniProt: Q99608

  • Chr Location
    15q11.2; chr15:23685400-23687305 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ndn mouse models; 1 with human NDN associations

Human Disease Mouse Models
      
IDs
 View 8 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    10 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 5 alleles in 9 genetic backgrounds
    3 images
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial neonatal lethality, cyanosis and respiratory distress. Mice heterozygous for a knock-out allele exhibit abnormal behavior, abnormal nervous system morphology and physiology and, when inherited maternally, postnatal lethality with cyanosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1416
  • Tissues
    329
  • cDNA Data
    151
  • Literature Summary
    60
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17984 NCBI Gene Model | MGI Sequence Detail 1652 C57BL/6J ±  kb
    transcript NM_010882 RefSeq | MGI Sequence Detail 1652 ZRU/MplStud  
    polypeptide P25233 UniProt | EBI | MGI Sequence Detail 325 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 172
      Genomic 5
      cDNA 152
      Primer pair 12
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12799, MGI:2141993
    References
    more
    • Summaries
      All 163
      Developmental Gene Expression 60
      Diseases 10
      Gene Ontology 17
      Phenotypes 66
    • Earliest
      J:10024 Prieto J, et al., MALA-2, mouse homologue of human adhesion molecule ICAM-1 (CD54). Eur J Immunol. 1989 Sep;19(9):1551-7
    • Latest
      J:353245 Dong Y, et al., Deficiency in Prader-Willi syndrome gene necdin leads to attenuated cardiac contractility. iScience. 2024 Jun 21;27(6):109974
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory