Nfya MGI Mouse Gene Detail - MGI:97316 - nuclear transcription factor-Y alpha

Symbol

Nfya
Name

nuclear transcription factor-Y alpha
Synonyms

Cbf-b, Sez10

Feature Type

protein coding gene
IDs

MGI:97316
NCBI Gene: 18044
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr17:48693917-48716782 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 23.99 cM, cytoband C-D
Mapping Data

7 experiments

SNPs within 2kb

633 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97316	protein coding gene	Chr17:48693913-48716934 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023871	protein coding gene	Chr17:49673895-49702260 (-)
A/J	MGP_AJ_G0023831	protein coding gene	Chr17:48366627-48389317 (-)
AKR/J	MGP_AKRJ_G0023799	protein coding gene	Chr17:48848655-48875506 (-)
BALB/cJ	MGP_BALBcJ_G0023833	protein coding gene	Chr17:48289314-48311915 (-)
C3H/HeJ	MGP_C3HHeJ_G0023596	protein coding gene	Chr17:49556242-49580080 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024276	protein coding gene	Chr17:51787040-51811281 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021725	protein coding gene	Chr17:45122411-45144833 (-)
CAST/EiJ	MGP_CASTEiJ_G0023078	protein coding gene	Chr17:49741177-49764601 (-)
CBA/J	MGP_CBAJ_G0023572	protein coding gene	Chr17:53642500-53672908 (-)
DBA/2J	MGP_DBA2J_G0023701	protein coding gene	Chr17:47130612-47155644 (-)
FVB/NJ	MGP_FVBNJ_G0023667	protein coding gene	Chr17:46796528-46819149 (-)
LP/J	MGP_LPJ_G0023781	protein coding gene	Chr17:50378106-50406486 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023695	protein coding gene	Chr17:53128306-53152059 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024322	protein coding gene	Chr17:49182411-49206488 (-)
PWK/PhJ	MGP_PWKPhJ_G0022823	protein coding gene	Chr17:46568951-46591574 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022637	protein coding gene	Chr17:46087933-46110356 (-)
WSB/EiJ	MGP_WSBEiJ_G0023142	protein coding gene	Chr17:49780221-49804027 (-)

Human Ortholog

NFYA, nuclear transcription factor Y subunit alpha

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NFYA, nuclear transcription factor Y subunit alpha
Synonyms

CBF-A, CBF-B, HAP2, NF-YA
Links

HGNC:7804

NCBI Gene ID: 4800

neXtProt AC: NX_P23511

UniProt: P23511
Chr Location

6p21.1; chr6:41072974-41102403 (+) GRCh38

MGI Vertebrate Homology

Nfya stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NFYA
Gene Tree

Nfya

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Phenotype Summary

4 phenotypes from 2 alleles in 1 genetic background
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

107
Endonuclease-mediated

5
Gene trapped

97
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

81 strains or lines available

Inactivation of this locus impairs development and results in embryonic lethality.

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All GO Annotations

35
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

798
Tissues

84
cDNA Data

118
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NFYA

Xenbase nfya

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All Sequences

99
RefSeq

32
UniProt

10
CCDS

CCDS28867.1, CCDS50142.1, CCDS84320.1, CCDS84321.1, CCDS89116.1

Ensembl

ENSMUSG00000023994 (Evidence)
NCBI Gene

18044

			Length	Strain/Species	Flank
genomic	18044	NCBI Gene Model \| MGI Sequence Detail	22866	C57BL/6J	± kb
transcript	NM_001110832	RefSeq \| MGI Sequence Detail	3641	ZRU/MplStud
polypeptide	P23708	UniProt \| EBI \| MGI Sequence Detail	346	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000011188 nuclear transcription factor Y subunit alpha

(term hierarchy)
InterPro Domains

IPR018362 CCAAT-binding factor, conserved site

IPR001289 Nuclear transcription factor Y subunit A

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All nucleic 127

Genomic 4

cDNA 118

Primer pair 3

Other 2

Microarray probesets 5

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MGD-MRK-12835, MGI:2146744

Summaries

All 94

Developmental Gene Expression 14

Gene Ontology 16

Phenotypes 25
Earliest

J:10763 van Huijsduijnen RH, et al., Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits. EMBO J. 1990 Oct;9(10):3119-27
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nfya:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr148537	Chr17:48716757-48716794 (-)	6 bp
Tssr148536	Chr17:48716616-48716627 (-)	160 bp
Tssr148535	Chr17:48716505-48716553 (-)	253 bp
Tssr148534	Chr17:48716038-48716055 (-)	735 bp
Tssr148533	Chr17:48716013-48716024 (-)	763 bp
Tssr148532	Chr17:48695624-48695637 (-)	21,151 bp
Tssr148531	Chr17:48695421-48695432 (-)	21,355 bp
Tssr148530	Chr17:48695176-48695190 (-)	21,599 bp
Tssr148529	Chr17:48695024-48695045 (-)	21,747 bp
Tssr148528	Chr17:48694994-48695020 (-)	21,775 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24