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Ngf Gene Detail
Summary
  • Symbol
    Ngf
  • Name
    nerve growth factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:97321
    NCBI Gene: 18049
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:102377235-102428329 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.25 cM
  • Mapping Data
    32 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1362 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97321
 protein coding gene Chr3:102377235-102428329 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027682
 protein coding gene Chr3:103696802-103749604 (+)
A/J MGP_AJ_G0027641
 protein coding gene Chr3:100395947-100447846 (+)
AKR/J MGP_AKRJ_G0027607
 protein coding gene Chr3:102885748-102937498 (+)
BALB/cJ MGP_BALBcJ_G0027654
 protein coding gene Chr3:100161877-100212854 (+)
C3H/HeJ MGP_C3HHeJ_G0027383
 protein coding gene Chr3:103174622-103228515 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028097
 protein coding gene Chr3:107528888-107579819 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025438
 protein coding gene Chr3:96569975-96621637 (+)
CAST/EiJ MGP_CASTEiJ_G0026839
 protein coding gene Chr3:102301473-102354787 (+)
CBA/J MGP_CBAJ_G0027358
 protein coding gene Chr3:111201208-111253963 (+)
DBA/2J MGP_DBA2J_G0027501
 protein coding gene Chr3:99651107-99702167 (+)
FVB/NJ MGP_FVBNJ_G0027469
 protein coding gene Chr3:97580217-97633469 (+)
LP/J MGP_LPJ_G0027608
 protein coding gene Chr3:105044844-105098393 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027499
 protein coding gene Chr3:117342472-117395572 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028152
 protein coding gene Chr3:102389163-102440110 (+)
PWK/PhJ MGP_PWKPhJ_G0026566
 protein coding gene Chr3:99405623-99457644 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026388
 protein coding gene Chr3:100466039-100521506 (+)
WSB/EiJ MGP_WSBEiJ_G0026919
 protein coding gene Chr3:102937208-102989297 (+)



Homology
more
  • Human Ortholog
    NGF, nerve growth factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NGF, nerve growth factor
  • Synonyms
    Beta-NGF, HSAN5, NGFB
  • Links
    NCBI Gene ID: 4803
    neXtProt AC: NX_P01138
    UniProt: P01138

  • Chr Location
    1p13.2; chr1:115285904-115338770 (-)  GRCh38
  • MGI Vertebrate Homology
    Ngf stringent orthology
    1 human;1 mouse;1 rat;2 zebrafish
  • HCOP
    vertebrate homology predictions: NGF
  • Protein SuperFamily
    NGF
  • Gene Tree
    Ngf
Human Diseases
more
  • Diseases
    11 with human NGF associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
 View 2 models
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 5 alleles in 6 genetic backgrounds
    24 phenotypes from multigenic genotypes
    3 images
    85 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit elevated pain threshold, loss of neurons in both sensory and sympathetic ganglia, but diminished apoptosis in the retina and spinal cord. Heterozygotes exhibit a substantially reduced number of sympathetic neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    847
  • Tissues
    113
  • cDNA Data
    38
  • Literature Summary
    55
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18049 NCBI Gene Model | MGI Sequence Detail 51095 C57BL/6J ±  kb
    transcript NM_013609 RefSeq | MGI Sequence Detail 1196 FVB/N  
    polypeptide P01139 UniProt | EBI | MGI Sequence Detail 241 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 3
      cDNA 40
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12840
    References
    more
    • Summaries
      All 293
      Developmental Gene Expression 55
      Diseases 3
      Gene Ontology 29
      Phenotypes 85
    • Earliest
      J:135487 Bothwell MA, et al., Dissociation equilibrium constant of beta nerve growth factor. J Biol Chem. 1977 Dec 10;252(23):8532-6
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory