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Mycn Gene Detail
Summary
  • Symbol
    Mycn
  • Name
    v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
  • Synonyms
    bHLHe37, N-myc, Nmyc, Nmyc-1, Nmyc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97357
    NCBI Gene: 18109
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:12986094-12991837 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 6.14 cM, cytoband A3-B
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97357
 protein coding gene Chr12:12986094-12991915 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019604
 protein coding gene Chr12:10167295-10173113 (-)
A/J MGP_AJ_G0019570
 protein coding gene Chr12:9842497-9848316 (-)
AKR/J MGP_AKRJ_G0019541
 protein coding gene Chr12:10438420-10444241 (-)
BALB/cJ MGP_BALBcJ_G0019547
 protein coding gene Chr12:10029196-10035014 (-)
C3H/HeJ MGP_C3HHeJ_G0019352
 protein coding gene Chr12:10267751-10273572 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019995
 protein coding gene Chr12:10540846-10546664 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017621
 protein coding gene Chr12:9517257-9523107 (-)
CAST/EiJ MGP_CASTEiJ_G0018907
 protein coding gene Chr12:10149019-10153923 (-)
CBA/J MGP_CBAJ_G0019323
 protein coding gene Chr12:11249214-11255035 (-)
DBA/2J MGP_DBA2J_G0019436
 protein coding gene Chr12:9801752-9807572 (-)
FVB/NJ MGP_FVBNJ_G0019427
 protein coding gene Chr12:9703426-9709247 (-)
LP/J MGP_LPJ_G0019507
 protein coding gene Chr12:10289346-10295164 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019461
 protein coding gene Chr12:11016099-11021920 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020034
 protein coding gene Chr12:10069229-10075047 (-)
PWK/PhJ MGP_PWKPhJ_G0018673
 protein coding gene Chr12:9866390-9871321 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018463
 protein coding gene Chr12:10204694-10209593 (-)
WSB/EiJ MGP_WSBEiJ_G0018958
 protein coding gene Chr12:10166368-10172189 (-)



Homology
more
  • Human Ortholog
    MYCN, MYCN proto-oncogene, bHLH transcription factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYCN, MYCN proto-oncogene, bHLH transcription factor
  • Synonyms
    bHLHe37, FGLDS1, MODED, MPAPA, MYCNsORF, MYCNsPEP, N-myc, NMYC, ODED
  • Links
    NCBI Gene ID: 4613
    neXtProt AC: NX_P04198
    UniProt: P04198

  • Chr Location
    2p24.3; chr2:15940550-15947007 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MYCN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    106 phenotypes from 11 alleles in 9 genetic backgrounds
    9 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired development of the mesonephric tubules, neuroepithelium, sensory ganglia, heart, lung, stomach, and liver. Mutants die around embryonic day 11.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1584
  • Tissues
    387
  • cDNA Data
    59
  • Literature Summary
    171
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18109 NCBI Gene Model | MGI Sequence Detail 5744 C57BL/6J ±  kb
    transcript NM_008709 RefSeq | MGI Sequence Detail 2596 ZRU/MplStud  
    polypeptide P03966 UniProt | EBI | MGI Sequence Detail 462 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010812 N-myc proto-oncogene protein
      (term hierarchy)
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR050433 Myc family transcription factors
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR002418 Transcription regulator Myc
      IPR012682 Transcription regulator Myc, N-terminal
    • GlyGen
      P03966 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 100
      Genomic 7
      cDNA 64
      Primer pair 15
      Other 14

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-12903, MGD-MRK-12905
    References
    more
    • Summaries
      All 298
      Developmental Gene Expression 171
      Gene Ontology 12
      Phenotypes 58
    • Earliest
      J:7964 Yancopoulos GD, et al., N-myc can cooperate with ras to transform normal cells in culture. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5455-9
    • Latest
      J:357531 Cheung BB, et al., Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis. Commun Biol. 2024 Oct 14;7(1):1322
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory