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Ntf3 Gene Detail
Summary
  • Symbol
    Ntf3
  • Name
    neurotrophin 3
  • Synonyms
    NT-3, NT3, Ntf-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97380
    NCBI Gene: 18205
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:126078375-126143703 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 60.45 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1843 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97380
 protein coding gene Chr6:126078375-126143873 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031301
 protein coding gene Chr6:129511753-129579737 (-)
A/J MGP_AJ_G0031272
 protein coding gene Chr6:124604144-124671219 (-)
AKR/J MGP_AKRJ_G0031200
 protein coding gene Chr6:127986147-128059923 (-)
BALB/cJ MGP_BALBcJ_G0031279
 protein coding gene Chr6:124188752-124253127 (-)
C3H/HeJ MGP_C3HHeJ_G0031003
 protein coding gene Chr6:128098702-128165570 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031736
 protein coding gene Chr6:132905851-132976560 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028884
 protein coding gene Chr6:121802973-121865166 (-)
CAST/EiJ MGP_CASTEiJ_G0030384
 protein coding gene Chr6:128296105-128364977 (-)
CBA/J MGP_CBAJ_G0030964
 protein coding gene Chr6:138016960-138092289 (-)
DBA/2J MGP_DBA2J_G0031120
 protein coding gene Chr6:123513721-123579243 (-)
FVB/NJ MGP_FVBNJ_G0031069
 protein coding gene Chr6:122429599-122493213 (-)
LP/J MGP_LPJ_G0031200
 protein coding gene Chr6:129649404-129715613 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031108
 protein coding gene Chr6:141998184-142065689 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031771
 protein coding gene Chr6:127929721-127994323 (-)
PWK/PhJ MGP_PWKPhJ_G0030099
 protein coding gene Chr6:121759364-121824816 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029928
 protein coding gene Chr6:125988080-126059760 (-)
WSB/EiJ MGP_WSBEiJ_G0030469
 protein coding gene Chr6:128304852-128372798 (-)



Homology
more
  • Human Ortholog
    NTF3, neurotrophin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NTF3, neurotrophin 3
  • Synonyms
    HDNF, NGF-2, NGF2, NT-3, NT3
  • Links
    NCBI Gene ID: 4908
    neXtProt AC: NX_P20783
    UniProt: P20783

  • Chr Location
    12p13.31; chr12:5430332-5521536 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ntf3 mouse models; 2 with human NTF3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    121 phenotypes from 12 alleles in 18 genetic backgrounds
    23 phenotypes from multigenic genotypes
    127 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit loss of peripheral sensory and sympathetic neurons, lack of spinal propioceptive afferents and their sense organs, impaired suckling and movement, and postnatal lethality. Heterozygotes show mild defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1238
  • Tissues
    319
  • cDNA Data
    18
  • Literature Summary
    83
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18205 NCBI Gene Model | MGI Sequence Detail 65329 C57BL/6J ±  kb
    transcript NM_001410128 RefSeq | MGI Sequence Detail 1604 ZRU/MplStud  
    polypeptide P20181 UniProt | EBI | MGI Sequence Detail 258 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 6
      cDNA 19
      Primer pair 2
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12937, MGD-MRK-12939, MGI:1353664, MGI:2141474
    References
    more
    • Summaries
      All 273
      Developmental Gene Expression 83
      Diseases 1
      Gene Ontology 24
      Phenotypes 127
    • Earliest
      J:135487 Bothwell MA, et al., Dissociation equilibrium constant of beta nerve growth factor. J Biol Chem. 1977 Dec 10;252(23):8532-6
    • Latest
      J:350076 Tan JW, et al., Neurotrophin-3 from the dentate gyrus supports postsynaptic sites of mossy fiber-CA3 synapses and hippocampus-dependent cognitive functions. Mol Psychiatry. 2024 Apr;29(4):1192-1204
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory