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Ntrk3 Gene Detail
Summary
  • Symbol
    Ntrk3
  • Name
    neurotrophic tyrosine kinase, receptor, type 3
  • Synonyms
    TrkC
  • Feature Type
    protein coding gene
  • IDs
    MGI:97385
    NCBI Gene: 18213
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:77825711-78228865 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 44.01 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10161 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97385
 protein coding gene Chr7:77825707-78387760 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032377
 protein coding gene Chr7:79969137-80565559 (-)
A/J MGP_AJ_G0032356
 protein coding gene Chr7:78163918-78732797 (-)
AKR/J MGP_AKRJ_G0032292
 protein coding gene Chr7:79833766-80422910 (-)
BALB/cJ MGP_BALBcJ_G0032368
 protein coding gene Chr7:77862167-78428078 (-)
C3H/HeJ MGP_C3HHeJ_G0032081
 protein coding gene Chr7:80496400-81081947 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032860
 protein coding gene Chr7:83153690-83737835 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029868
 protein coding gene Chr7:80738170-81296643 (-)
CAST/EiJ MGP_CASTEiJ_G0031409
 protein coding gene Chr7:71343623-71926542 (-)
CBA/J MGP_CBAJ_G0032047
 protein coding gene Chr7:85883308-86501196 (-)
DBA/2J MGP_DBA2J_G0032202
 protein coding gene Chr7:76751915-77325164 (-)
FVB/NJ MGP_FVBNJ_G0032157
 protein coding gene Chr7:76663659-77224439 (-)
LP/J MGP_LPJ_G0032283
 protein coding gene Chr7:81228688-81815807 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032194
 protein coding gene Chr7:86186669-86777033 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032878
 protein coding gene Chr7:79285266-79860569 (-)
PWK/PhJ MGP_PWKPhJ_G0031129
 protein coding gene Chr7:69902621-70469308 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030970
 protein coding gene Chr7:66259782-66847447 (-)
WSB/EiJ MGP_WSBEiJ_G0031527
 protein coding gene Chr7:79604848-80181571 (-)



Homology
more
  • Human Ortholog
    NTRK3, neurotrophic receptor tyrosine kinase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NTRK3, neurotrophic receptor tyrosine kinase 3
  • Synonyms
    gp145(trkC), GP145-TrkC, TRKC
  • Links
    NCBI Gene ID: 4916
    neXtProt AC: NX_Q16288
    UniProt: Q16288

  • Chr Location
    15q25.3; chr15:87859751-88256791 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human NTRK3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 7 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    102 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations show a range of phenotypes including postnatal death at 2-21 days, cardiac defects, reduced numbers of dorsal root ganglia neurons and germ cells, abnormal motor coordination and posture and abnormal sensory innervation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    87
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1528
  • Tissues
    408
  • cDNA Data
    17
  • Literature Summary
    187
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18213 NCBI Gene Model | MGI Sequence Detail 403155 C57BL/6J ±  kb
    transcript NM_182809 RefSeq | MGI Sequence Detail 3847 ZRU/MplStud  
    polypeptide Q6VNS1 UniProt | EBI | MGI Sequence Detail 825 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 23
      Primer pair 7
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12944, MGI:2142211
    References
    more
    • Summaries
      All 322
      Developmental Gene Expression 187
      Diseases 1
      Gene Ontology 20
      Phenotypes 102
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:354180 Xu M, et al., ISL1 and POU4F1 Directly Interact to Regulate the Differentiation and Survival of Inner Ear Sensory Neurons. J Neurosci. 2024 Feb 21;44(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory