Nuca Gene Detail

Summary

• Symbol
  Nuca
• Name
  dominant nuclear cataract

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:97387
  NCBI Gene: 104352
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Human Diseases

• Diseases
  1 with Nuca mouse models

Human Disease

Mouse Models

cataract

IDs

cataract      

DOID:83
ICD10CM:H26
ICD9CM:366.8
OMIM:601371
OMIM:PS116200
UMLS_CUI:C0029531

View 1 model

Mouse Models

Human Disease Modeled: cataract

Allelic Composition	Genetic Background	Reference	Phenotypes
Nuca/Nuca+	involves: 101 * C3H	J:6686	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotypes from 1 allele in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  1
• Radiation induced
  1
• Find Mice (IMSR)
  0 strains or lines available

Heterozygotes exhibit opacities of the embryonic lens nucleus and the posterior embryonic suture. Most are also sterile and those that are fertile have reduced litter size. Homozygotes die prenatally.

Sequences &
Gene Models

• NCBI Gene
  104352

Other
Accession IDs

MGD-MRK-12948

References

• Summaries
  All 3

  Diseases 1

  Phenotypes 2
• Earliest
  J:6686 Kratochvilova J, Dominant cataract mutations detected in offspring of gamma-irradiated male mice. J Hered. 1981 Sep-Oct;72(5):302-7
• Latest
  J:9528 Kratochvilova J, et al., Phenotypic characterization and genetic analysis of twenty dominant cataract mutations detected in offspring of irradiated male mice. Genet Res. 1988 Oct;52(2):125-34