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Nucb1 Gene Detail
Summary
  • Symbol
    Nucb1
  • Name
    nucleobindin 1
  • Synonyms
    B230337F23Rik, Calnuc, MTEST82
  • Feature Type
    protein coding gene
  • IDs
    MGI:97388
    NCBI Gene: 18220
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45142300-45159813 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    531 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97388
 protein coding gene Chr7:45139882-45159830 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032227
 protein coding gene Chr7:45765992-45784785 (-)
A/J MGP_AJ_G0032206
 protein coding gene Chr7:44881938-44899490 (-)
AKR/J MGP_AKRJ_G0032142
 protein coding gene Chr7:46127668-46145692 (-)
BALB/cJ MGP_BALBcJ_G0032218
 protein coding gene Chr7:44871013-44888608 (-)
C3H/HeJ MGP_C3HHeJ_G0031933
 protein coding gene Chr7:46613500-46633290 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032710
 protein coding gene Chr7:48035526-48053033 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029724
 protein coding gene Chr7:47427402-47445393 (-)
CAST/EiJ MGP_CASTEiJ_G0031262
 protein coding gene Chr7:38037772-38055048 (-)
CBA/J MGP_CBAJ_G0031898
 protein coding gene Chr7:49622574-49640045 (-)
DBA/2J MGP_DBA2J_G0032056
 protein coding gene Chr7:44546029-44563474 (-)
FVB/NJ MGP_FVBNJ_G0032007
 protein coding gene Chr7:44338704-44356300 (-)
LP/J MGP_LPJ_G0032134
 protein coding gene Chr7:46466418-46483881 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032044
 protein coding gene Chr7:48322227-48340656 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032726
 protein coding gene Chr7:45339852-45359233 (-)
PWK/PhJ MGP_PWKPhJ_G0030984
 protein coding gene Chr7:37925193-37942976 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030822
 protein coding gene Chr7:33344373-33364363 (-)
WSB/EiJ MGP_WSBEiJ_G0031379
 protein coding gene Chr7:45836918-45856124 (-)



Homology
more
  • Human Ortholog
    NUCB1, nucleobindin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUCB1, nucleobindin 1
  • Synonyms
    CALNUC, NUC
  • Links
    NCBI Gene ID: 4924
    neXtProt AC: NX_Q02818
    UniProt: Q02818

  • Chr Location
    19q13.33; chr19:48900050-48923473 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    4
  • cDNA Data
    312
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18220 NCBI Gene Model | MGI Sequence Detail 17514 C57BL/6J ±  kb
    transcript NM_001163662 RefSeq | MGI Sequence Detail 2418 C57BL/6  
    polypeptide Q02819 UniProt | EBI | MGI Sequence Detail 459 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 316
      Genomic 1
      cDNA 314
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12949, MGI:2142314, MGI:2444348
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:2162 Miura K, et al., Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine zipper structure. Biochem Biophys Res Commun. 1992 Aug 31;187(1):375-80
    • Latest
      J:349666 Nasri A, et al., Nesfatin-1 and nesfatin-1-like peptide attenuate hepatocyte lipid accumulation and nucleobindin-1 disruption modulates lipid metabolic pathways. Commun Biol. 2024 May 27;7(1):623
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory