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Oat Gene Detail
Summary
  • Symbol
    Oat
  • Name
    ornithine aminotransferase
  • Synonyms
    rhg
  • Feature Type
    protein coding gene
  • IDs
    MGI:97394
    NCBI Gene: 18242
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:132159207-132178127 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 76.30 cM
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • SNPs within 2kb
    629 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97394
 protein coding gene Chr7:132159204-132178127 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033112
 protein coding gene Chr7:137252713-137272428 (-)
A/J MGP_AJ_G0033094
 protein coding gene Chr7:133475988-133494911 (-)
AKR/J MGP_AKRJ_G0033026
 protein coding gene Chr7:137037409-137056544 (-)
BALB/cJ MGP_BALBcJ_G0033095
 protein coding gene Chr7:133158971-133177894 (-)
C3H/HeJ MGP_C3HHeJ_G0032809
 protein coding gene Chr7:136870691-136889641 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033606
 protein coding gene Chr7:142487582-142507930 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030577
 protein coding gene Chr7:134754880-134774202 (-)
CAST/EiJ MGP_CASTEiJ_G0032139
 protein coding gene Chr7:128770334-128789367 (-)
CBA/J MGP_CBAJ_G0032782
 protein coding gene Chr7:147313373-147336580 (-)
DBA/2J MGP_DBA2J_G0032934
 protein coding gene Chr7:131489746-131508602 (-)
FVB/NJ MGP_FVBNJ_G0032887
 protein coding gene Chr7:131313675-131332878 (-)
LP/J MGP_LPJ_G0033028
 protein coding gene Chr7:138754072-138774808 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032919
 protein coding gene Chr7:148247147-148266144 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033626
 protein coding gene Chr7:136018306-136038045 (-)
PWK/PhJ MGP_PWKPhJ_G0031845
 protein coding gene Chr7:124510601-124529627 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031691
 protein coding gene Chr7:122809876-122831594 (-)
WSB/EiJ MGP_WSBEiJ_G0032250
 protein coding gene Chr7:136924245-136945197 (-)



Homology
more
  • Human Ortholog
    OAT, ornithine aminotransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OAT, ornithine aminotransferase
  • Synonyms
    GACR, HOGA, OATASE, OKT
  • Links
    NCBI Gene ID: 4942
    neXtProt AC: NX_P04181
    UniProt: P04181

  • Chr Location
    10q26.13; chr10:124397303-124418976 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Oat mouse models; 1 with human OAT associations

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 2 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    5 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null mutants show neonatal hypoornithinemia and increased mortality prevented by administering arginine. Homozygotes for a spontaneous G353A point mutation have neonatal hypoornithinemia, adult hyperornithinemia, growth retardation, retarded fur development, cataracts, and retinal degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    347
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030934 Ensembl Gene Model | MGI Sequence Detail 18921 C57BL/6J ±  kb
    transcript ENSMUST00000084500 Ensembl | MGI Sequence Detail 2152 Not Applicable  
    polypeptide ENSMUSP00000081544 Ensembl | MGI Sequence Detail 439 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000011578 ornithine aminotransferase, mitochondrial
      (term hierarchy)
    • EC
      2.6.1.13
    • InterPro Domains
      IPR005814 Aminotransferase class-III
      IPR049704 Aminotransferases class-III pyridoxal-phosphate attachment site
      IPR050103 Class-III Pyridoxal-phosphate-dependent Aminotransferase
      IPR010164 Ornithine aminotransferase
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
      IPR015422 Pyridoxal phosphate-dependent transferase, small domain
    • GlyGen
      P29758 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 352
      Genomic 3
      cDNA 349

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12964, MGD-MRK-13865, MGI:2141877, MGI:97913
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 4
      Diseases 3
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:4833 O'Donnell JJ, et al., Ornithine aminotransferase (OAT) maps to human chromosome 10 and mouse chromosome 7. Cytogenet Cell Genet. 1985;40:716 (Abstr.)
    • Latest
      J:340007 Lee MS, et al., Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer. Nature. 2023 Apr;616(7956):339-347
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory