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Mog Gene Detail
Summary
  • Symbol
    Mog
  • Name
    myelin oligodendrocyte glycoprotein
  • Synonyms
    B230317G11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:97435
    NCBI Gene: 17441
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:37321635-37334290 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.16 cM, cytoband C
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97435
 protein coding gene Chr17:37321632-37334290 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023694
 protein coding gene Chr17:37375453-37388868 (-)
A/J MGP_AJ_G0023652
 protein coding gene Chr17:36192332-36205332 (-)
AKR/J MGP_AKRJ_G0023623
 protein coding gene Chr17:36628277-36640943 (-)
BALB/cJ MGP_BALBcJ_G0023659
 protein coding gene Chr17:36436336-36449293 (-)
C3H/HeJ MGP_C3HHeJ_G0023421
 protein coding gene Chr17:37144595-37157151 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024097
 protein coding gene Chr17:38967723-38984614 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021565
 protein coding gene Chr17:34007505-34020467 (-)
CAST/EiJ MGP_CASTEiJ_G0022906
 protein coding gene Chr17:37274214-37288583 (-)
CBA/J MGP_CBAJ_G0023398
 protein coding gene Chr17:40491779-40507555 (-)
DBA/2J MGP_DBA2J_G0023523
 protein coding gene Chr17:35583781-35596805 (-)
FVB/NJ MGP_FVBNJ_G0023496
 protein coding gene Chr17:35191330-35210004 (-)
LP/J MGP_LPJ_G0023601
 protein coding gene Chr17:37902432-37916908 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023519
 protein coding gene Chr17:39279314-39292732 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024142
 protein coding gene Chr17:36974300-36987970 (-)
PWK/PhJ MGP_PWKPhJ_G0022658
 protein coding gene Chr17:34369233-34380171 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022477
 protein coding gene Chr17:35064536-35079205 (-)
WSB/EiJ MGP_WSBEiJ_G0022973
 protein coding gene Chr17:37290205-37306283 (-)



Homology
more
  • Human Ortholog
    MOG, myelin oligodendrocyte glycoprotein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MOG, myelin oligodendrocyte glycoprotein
  • Synonyms
    BTN6, BTNL11, MOGIG2, NRCLP7
  • Links
    NCBI Gene ID: 4340
    neXtProt AC: NX_Q16653
    UniProt: Q16653

  • Chr Location
    6p22.1; chr6:29657002-29672372 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human MOG associations

Human Disease Mouse Models
      
IDs
 View 4 models
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    26 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
While one line of homozygous mutant mice showed resistance to experimental autoimmune encephalomyelitis (EAE), another showed increased susceptibility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    12
  • cDNA Data
    17
  • Literature Summary
    17
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000076439 Ensembl Gene Model | MGI Sequence Detail 12656 C57BL/6J ±  kb
transcript ENSMUST00000102665 Ensembl | MGI Sequence Detail 1704 Not Applicable  
polypeptide ENSMUSP00000099726 Ensembl | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000010514 myelin-oligodendrocyte glycoprotein
    (term hierarchy)
  • PDB
    1PY9
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR050504 Immunoglobulin superfamily BTN/MOG domain-containing protein
    IPR013106 Immunoglobulin V-set domain
    IPR016663 Myelin-oligodendrocyte glycoprotein
  • GlyGen
    Q61885 2 sites, 15 N-linked glycans (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 47
    Genomic 20
    cDNA 20
    Primer pair 4
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13032, MGI:2443229
References
more
  • Summaries
    All 117
    Developmental Gene Expression 17
    Diseases 1
    Gene Ontology 5
    Phenotypes 45
  • Earliest
    J:849 Amiguet P, et al., Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein. J Neurochem. 1992 May;58(5):1676-82
  • Latest
    J:352769 Fiore F, et al., Norepinephrine regulates calcium signals and fate of oligodendrocyte precursor cells in the mouse cerebral cortex. Nat Commun. 2023 Dec 8;14(1):8122
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory