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Oprd1 Gene Detail
Summary
  • Symbol
    Oprd1
  • Name
    opioid receptor, delta 1
  • Synonyms
    DOR, DOR-1, mDOR, Nbor
  • Feature Type
    protein coding gene
  • IDs
    MGI:97438
    NCBI Gene: 18386
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:131838037-131871797 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 64.78 cM, cytoband D1-D3
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1228 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97438
 protein coding gene Chr4:131834980-131872042 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028863
 protein coding gene Chr4:134235453-134268926 (-)
A/J MGP_AJ_G0028822
 protein coding gene Chr4:128659045-128693208 (-)
AKR/J MGP_AKRJ_G0028775
 protein coding gene Chr4:132267184-132302712 (-)
BALB/cJ MGP_BALBcJ_G0028845
 protein coding gene Chr4:129271245-129305880 (-)
C3H/HeJ MGP_C3HHeJ_G0028559
 protein coding gene Chr4:132517630-132553319 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029287
 protein coding gene Chr4:139059530-139097815 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026559
 protein coding gene Chr4:121750110-121785323 (-)
CAST/EiJ MGP_CASTEiJ_G0027992
 protein coding gene Chr4:130586313-130625381 (-)
CBA/J MGP_CBAJ_G0028525
 protein coding gene Chr4:142620885-142663338 (-)
DBA/2J MGP_DBA2J_G0028674
 protein coding gene Chr4:129083955-129118583 (-)
FVB/NJ MGP_FVBNJ_G0028641
 protein coding gene Chr4:127935624-127970422 (-)
LP/J MGP_LPJ_G0028775
 protein coding gene Chr4:134392880-134427775 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028667
 protein coding gene Chr4:147243580-147278204 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029325
 protein coding gene Chr4:132664241-132708379 (-)
PWK/PhJ MGP_PWKPhJ_G0027713
 protein coding gene Chr4:125756622-125790636 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027539
 protein coding gene Chr4:128539866-128578520 (-)
WSB/EiJ MGP_WSBEiJ_G0028072
 protein coding gene Chr4:132844413-132881761 (-)



Homology
more
  • Human Ortholog
    OPRD1, opioid receptor delta 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OPRD1, opioid receptor delta 1
  • Synonyms
    DOP, DOR, DOR1, OPRD
  • Links
    NCBI Gene ID: 4985
    neXtProt AC: NX_P41143
    UniProt: P41143

  • Chr Location
    1p35.3; chr1:28812170-28871267 (+)  GRCh38
Human Diseases
more
  • Diseases
    7 with human OPRD1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 5 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele do not develop analgesic tolerance to morphine while mice homozygous for a different knock-out allele exhibit hyperactivity, increased anxiety, and decreased coping response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    62
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    928
  • Tissues
    134
  • cDNA Data
    18
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050511 Ensembl Gene Model | MGI Sequence Detail 33761 C57BL/6J ±  kb
transcript ENSMUST00000056336 Ensembl | MGI Sequence Detail 4021 Not Applicable  
polypeptide ENSMUSP00000050077 Ensembl | MGI Sequence Detail 372 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    Genomic 5
    cDNA 19
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12783, MGD-MRK-13038
References
more
  • Summaries
    All 165
    Developmental Gene Expression 11
    Gene Ontology 11
    Phenotypes 72
  • Earliest
    J:14060 Evans CJ, et al., Cloning of a delta opioid receptor by functional expression [see comments]. Science. 1992 Dec 18;258(5090):1952-5
  • Latest
    J:354144 Miao H, et al., Neuroprotective effects of miRNA-326 knockout in neonatal hypoxic-ischemic brain damage mice via the delta-opioid receptor. Biochem Biophys Res Commun. 2024 Sep 24;726:150259
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory