Orm1 MGI Mouse Gene Detail - MGI:97443

Symbol

Orm1
Name

orosomucoid 1
Synonyms

Agp-1, Agp-2, Orm-1

Feature Type

protein coding gene
IDs

MGI:97443
NCBI Gene: 18405
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr4:63262797-63266400 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 33.96 cM
Mapping Data

23 experiments

SNPs within 2kb

302 from dbSNP Build 142
Strain Annotations

16
PCR

3
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97443	protein coding gene	Chr4:63262793-63266400 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028364	protein coding gene	Chr4:62354928-62358558 (+)
A/J	MGP_AJ_G0028325	protein coding gene	Chr4:60103353-60106956 (+)
AKR/J	MGP_AKRJ_G0028274	protein coding gene	Chr4:61743167-61746771 (+)
BALB/cJ	MGP_BALBcJ_G0028345	protein coding gene	Chr4:60293922-60297525 (+)
C3H/HeJ	MGP_C3HHeJ_G0028063	protein coding gene	Chr4:62269203-62272806 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028785	protein coding gene	Chr4:64486865-64491947 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0027499	protein coding gene	Chr4:60237300-60240924 (+)
CBA/J	MGP_CBAJ_G0028030	protein coding gene	Chr4:66739083-66744794 (+)
DBA/2J	MGP_DBA2J_G0028180	protein coding gene	Chr4:59957524-59961127 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0028277	protein coding gene	Chr4:62623140-62626744 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028172	protein coding gene	Chr4:69839147-69843871 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028821	protein coding gene	Chr4:61860863-61864493 (+)
PWK/PhJ	MGP_PWKPhJ_G0027226	protein coding gene	Chr4:58469771-58478773 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027055	protein coding gene	Chr4:59311329-59313256 (+)
WSB/EiJ	MGP_WSBEiJ_G0027579	protein coding gene	Chr4:61859384-61864471 (+)

Human Ortholog

ORM1, orosomucoid 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ORM1, orosomucoid 1
Synonyms

A1AG1, AGP1, AGP-A, HEL-S-153w, ORM
Links

HGNC:8498

NCBI Gene ID: 5004

neXtProt AC: NX_P02763

UniProt: P02763
Chr Location

9q32; chr9:114323098-114326479 (+) GRCh38

Human Ortholog

ORM2, orosomucoid 2
Synonyms

AGP2, AGP-B, AGP-B'
Links

HGNC:8499

NCBI Gene ID: 5005

neXtProt AC: NX_P19652

UniProt: P19652
Chr Location

9q32; chr9:114329869-114333251 (+) GRCh38

MGI Vertebrate Homology

Orm1 stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ORM1, ORM2
Protein SuperFamily

AGP
Gene Tree

Orm1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

4
Targeted

2
Genomic Mutations

1 involving Orm1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired exercise endurance in a forced swimming test.

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

70
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

3
CCDS

CCDS18251.1

Ensembl

ENSMUSG00000039196 (Evidence)
NCBI Gene

18405

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039196	Ensembl Gene Model \| MGI Sequence Detail	3604	C57BL/6J	± kb
transcript	ENSMUST00000030044	Ensembl \| MGI Sequence Detail	775	Not Applicable
polypeptide	ENSMUSP00000030044	Ensembl \| MGI Sequence Detail	207	Not Applicable

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UniProt

3 Sequences
InterPro Domains

IPR001500 Alpha-1-acid glycoprotein

IPR012674 Calycin

IPR000566 Lipocalin/cytosolic fatty-acid binding domain
GlyGen

Q60590 6 sites, 8 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 78

Genomic 2

cDNA 73

Primer pair 3

Microarray probesets 4

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MGD-MRK-13048, MGD-MRK-13051

Summaries

All 71

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 9
Earliest

J:6919 Baumann H, et al., Dexamethasone regulation of alpha 1-acid glycoprotein and other acute phase reactants in rat liver and hepatoma cells. J Biol Chem. 1983 Jan 10;258(1):563-70
Latest

J:358102 Nakamura Y, et al., Contribution of the alpha(1)-Acid Glycoprotein in Drug Pharmacokinetics: The Usefulness of alpha(1)-Acid Glycoprotein-Knockout Mice. Mol Pharm. 2024 Jul 1;21(7):3144-3150

TSS for Orm1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37539	Chr4:63262546-63262554 (+)	-247 bp
Tssr1194	Chr4:63262681-63262685 (+)	-114 bp
Tssr1195	Chr4:63262711-63262719 (+)	-82 bp
Tssr1196	Chr4:63262727-63262742 (+)	-62 bp
Tssr37540	Chr4:63262756-63262770 (+)	-34 bp
Tssr37541	Chr4:63262785-63262830 (+)	11 bp
Tssr37542	Chr4:63262839-63262846 (+)	46 bp
Tssr37543	Chr4:63262850-63262864 (+)	60 bp
Tssr37544	Chr4:63262887-63262894 (+)	94 bp
Tssr37545	Chr4:63263323-63263337 (+)	533 bp
Tssr37546	Chr4:63263389-63263417 (+)	606 bp
Tssr37547	Chr4:63264277-63264294 (+)	1,489 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24