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Orm2 Gene Detail
Summary
  • Symbol
    Orm2
  • Name
    orosomucoid 2
  • Synonyms
    Orm-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97444
    NCBI Gene: 18406
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:63280686-63284115 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 33.96 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    365 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97444
 protein coding gene Chr4:63280543-63284115 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028366
 protein coding gene Chr4:62367302-62370721 (+)
A/J MGP_AJ_G0028327
 protein coding gene Chr4:60125568-60128985 (+)
AKR/J MGP_AKRJ_G0028277
 protein coding gene Chr4:61766005-61769422 (+)
BALB/cJ MGP_BALBcJ_G0028347
 protein coding gene Chr4:60314221-60317692 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0028787
 protein coding gene Chr4:64507646-64511077 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0027501
 protein coding gene Chr4:60268736-60272152 (+)
CBA/J MGP_CBAJ_G0028032
 protein coding gene Chr4:66764706-66769532 (+)
DBA/2J MGP_DBA2J_G0028181
 protein coding gene Chr4:59979428-59982844 (+)
FVB/NJ MGP_FVBNJ_G0028146
 protein coding gene Chr4:59255087-59258508 (+)
LP/J MGP_LPJ_G0028279
 protein coding gene Chr4:62646459-62651531 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028175
 protein coding gene Chr4:69876683-69880988 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028823
 protein coding gene Chr4:61873237-61876656 (+)
PWK/PhJ MGP_PWKPhJ_G0027230
 protein coding gene Chr4:58511524-58515711 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0027581
 protein coding gene Chr4:61900067-61902024 (+)



Homology
more
  • Human Ortholog
    ORM1, orosomucoid 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ORM1, orosomucoid 1
  • Synonyms
    A1AG1, AGP1, AGP-A, HEL-S-153w, ORM
  • Links
    NCBI Gene ID: 5004
    neXtProt AC: NX_P02763
    UniProt: P02763

  • Chr Location
    9q32; chr9:114323098-114326479 (+)  GRCh38
  • Human Ortholog
    ORM2, orosomucoid 2
  • Synonyms
    AGP2, AGP-B, AGP-B'
  • Links
    NCBI Gene ID: 5005
    neXtProt AC: NX_P19652
    UniProt: P19652

  • Chr Location
    9q32; chr9:114329869-114333251 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display increased susceptibility to diet induced hepatic steatosis and dyslipidemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061540 Ensembl Gene Model | MGI Sequence Detail 3430 C57BL/6J ±  kb
    transcript ENSMUST00000075341 Ensembl | MGI Sequence Detail 775 Not Applicable  
    polypeptide ENSMUSP00000074810 Ensembl | MGI Sequence Detail 207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 3
      cDNA 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13049, MGD-MRK-13052
    References
    more
    • Summaries
      All 40
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:7384 Baumann H, et al., The acute phase response of mouse liver. Genetic analysis of the major acute phase reactants. J Biol Chem. 1984 Jan 10;259(1):566-73
    • Latest
      J:338144 Li L, et al., Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARgamma-Cd36 pathway. Cell Rep. 2023 Jun 24;42(7):112697
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory