Osbp MGI Mouse Gene Detail - MGI:97447 - oxysterol binding protein

Symbol

Osbp
Name

oxysterol binding protein
Synonyms

1110018F06Rik

Feature Type

protein coding gene
IDs

MGI:97447
NCBI Gene: 76303
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr19:11943305-11971476 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 8.58 cM
Mapping Data

12 experiments

SNPs within 2kb

702 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97447	protein coding gene	Chr19:11943208-11971478 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024890	protein coding gene	Chr19:9367420-9397668 (+)
A/J	MGP_AJ_G0024866	protein coding gene	Chr19:8847661-8876282 (+)
AKR/J	MGP_AKRJ_G0024839	protein coding gene	Chr19:9183367-9211556 (+)
BALB/cJ	MGP_BALBcJ_G0024866	protein coding gene	Chr19:8853896-8881870 (+)
C3H/HeJ	MGP_C3HHeJ_G0024630	protein coding gene	Chr19:9079689-9109134 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025314	protein coding gene	Chr19:9849999-9892077 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022740	protein coding gene	Chr19:9430363-9458878 (+)
CAST/EiJ	MGP_CASTEiJ_G0024103	protein coding gene	Chr19:8685882-8713783 (+)
CBA/J	MGP_CBAJ_G0024605	protein coding gene	Chr19:9908874-9939669 (+)
DBA/2J	MGP_DBA2J_G0024733	protein coding gene	Chr19:8811757-8839480 (+)
FVB/NJ	MGP_FVBNJ_G0024698	protein coding gene	Chr19:8842489-8870475 (+)
LP/J	MGP_LPJ_G0024820	protein coding gene	Chr19:9379305-9409037 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024725	protein coding gene	Chr19:9812734-9841581 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025362	protein coding gene	Chr19:9166570-9196894 (+)
PWK/PhJ	MGP_PWKPhJ_G0023848	protein coding gene	Chr19:8283446-8311353 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023653	protein coding gene	Chr19:8350804-8378888 (+)
WSB/EiJ	MGP_WSBEiJ_G0024165	protein coding gene	Chr19:9027352-9057752 (+)

Human Ortholog

OSBP, oxysterol binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OSBP, oxysterol binding protein
Synonyms

OSBP1
Links

HGNC:8503

NCBI Gene ID: 5007

neXtProt AC: NX_P22059

UniProt: P22059
Chr Location

11q12.1; chr11:59574398-59615774 (-) GRCh38

MGI Vertebrate Homology

Osbp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: OSBP
Gene Tree

Osbp

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
1 images
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Gene trapped

4
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show complete embryonic lethality by E7.5. In vitro outgrowth assays show that blastocysts hatch from the zona pellucida but form irregular outgrowths with no inner cell mass colony or trophoblast giant cells after 3 days in culture.

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All GO Annotations

46
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

24
cDNA Data

16
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase osbp

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All Sequences

44
RefSeq

4
UniProt

1
CCDS

CCDS37925.1

Ensembl

ENSMUSG00000024687 (Evidence)
NCBI Gene

76303

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024687	Ensembl Gene Model \| MGI Sequence Detail	28172	C57BL/6J	± kb
transcript	ENSMUST00000025590	Ensembl \| MGI Sequence Detail	4488	Not Applicable
polypeptide	ENSMUSP00000025590	Ensembl \| MGI Sequence Detail	805	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000012043 oxysterol-binding protein 1

(term hierarchy)
InterPro Domains

IPR000648 Oxysterol-binding protein

IPR037239 Oxysterol-binding protein superfamily

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain
GlyGen

Q3B7Z2 1 site, 1 O-linked glycan (1 site)

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All nucleic 20

cDNA 18

Primer pair 2

Microarray probesets 4

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MGD-MRK-13055, MGI:1923553, MGI:2147753

Summaries

All 51

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 11
Earliest

J:10477 Levanon D, et al., cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19. Genomics. 1990 May;7(1):65-74
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Osbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155300	Chr19:11943056-11943070 (+)	-242 bp
Tssr155301	Chr19:11943152-11943175 (+)	-141 bp
Tssr155302	Chr19:11943181-11943251 (+)	-89 bp
Tssr155303	Chr19:11943265-11943294 (+)	-25 bp
Tssr155304	Chr19:11947663-11947675 (+)	4,364 bp
Tssr155305	Chr19:11954353-11954359 (+)	11,051 bp
Tssr155306	Chr19:11954385-11954396 (+)	11,086 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24