Oua1 Gene Detail

Summary

• Symbol
  Oua1
• Name
  ouabain resistance 1
• Synonyms
  Oua-1

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:97452
  NCBI Gene: 18425
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

Ouabain, a glycoside with cardiac effects similar to digitalis, interacts with APTase and affects cation and amino acid transport. Cell lines carrying mouse Oua1 gene express a mutant Atp1a1 with one amino acid substitution. Oua1 shows sequence homology to upstream regulatory regions of gene Atp1a1.

Sequences &
Gene Models

• All Sequences
  2

• NCBI Gene
  18425

Representative Sequences			Length	Strain/Species
genomic	S55685	GenBank | ENA | DDBJ | MGI Sequence Detail	6395	Not Specified

Molecular
Reagents

• All nucleic 1

  Genomic 1

Other
Accession IDs

MGD-MRK-13088, MGD-MRK-13089

References

• Summaries
  All 13
• Earliest
  J:12173 Coleman DL, Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch Biochem Biophys. 1962 Mar;96:562-8
• Latest
  J:30283 Dunn JF, et al., Ouabain sensitive Na+/K(+)-ATPase content is elevated in mdx mice: implications for the regulation of ions in dystrophic muscle. J Neurol Sci. 1995 Nov;133(1-2):11-5