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Pam Gene Detail
Summary
  • Symbol
    Pam
  • Name
    peptidylglycine alpha-amidating monooxygenase
  • Synonyms
    PHM
  • Feature Type
    protein coding gene
  • IDs
    MGI:97475
    NCBI Gene: 18484
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:97748816-98023578 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 47.76 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7463 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97475
 protein coding gene Chr1:97722839-98023578 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016361
 protein coding gene Chr1:99571522-99876272 (-)
A/J MGP_AJ_G0016345
 protein coding gene Chr1:96081759-96378702 (-)
AKR/J MGP_AKRJ_G0016305
 protein coding gene Chr1:98860438-99171790 (-)
BALB/cJ MGP_BALBcJ_G0016301
 protein coding gene Chr1:96240986-96546839 (-)
C3H/HeJ MGP_C3HHeJ_G0016128
 protein coding gene Chr1:99155815-99448958 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016760
 protein coding gene Chr1:103518684-103826862 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014478
 protein coding gene Chr1:90352457-90644671 (-)
CAST/EiJ MGP_CASTEiJ_G0015710
 protein coding gene Chr1:98276941-98587111 (-)
CBA/J MGP_CBAJ_G0016101
 protein coding gene Chr1:106907795-107253018 (-)
DBA/2J MGP_DBA2J_G0016206
 protein coding gene Chr1:95289030-95585783 (-)
FVB/NJ MGP_FVBNJ_G0016207
 protein coding gene Chr1:94285156-94583606 (-)
LP/J MGP_LPJ_G0016280
 protein coding gene Chr1:100860065-101169979 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016233
 protein coding gene Chr1:110631558-110947734 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016799
 protein coding gene Chr1:98873803-99183013 (-)
PWK/PhJ MGP_PWKPhJ_G0015498
 protein coding gene Chr1:94476120-94784208 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015282
 protein coding gene Chr1:97707531-98010914 (-)
WSB/EiJ MGP_WSBEiJ_G0015773
 protein coding gene Chr1:98709536-99019627 (-)



Homology
more
  • Human Ortholog
    PAM, peptidylglycine alpha-amidating monooxygenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAM, peptidylglycine alpha-amidating monooxygenase
  • Synonyms
    PAL, PAM-1, PHM
  • Links
    NCBI Gene ID: 5066
    neXtProt AC: NX_P19021
    UniProt: P19021

  • Chr Location
    5q21.1; chr5:102753981-103031105 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality during fetal growth and development, edema, abnormal yolk sac vasculature, thin arterial walls, and abnormal bronchial epithelial morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1007
  • Tissues
    59
  • cDNA Data
    9
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18484 NCBI Gene Model | MGI Sequence Detail 274763 C57BL/6J ±  kb
    transcript NM_001357127 RefSeq | MGI Sequence Detail 3995 ZRU/MplStud  
    polypeptide P97467 UniProt | EBI | MGI Sequence Detail 979 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000012252 peptidyl-glycine alpha-amidating monooxygenase
      (term hierarchy)
    • EC
      1.14.17.3, 4.3.2.5
    • InterPro Domains
      IPR024548 Copper type II ascorbate-dependent monooxygenase, C-terminal
      IPR020611 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
      IPR014783 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
      IPR014784 Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
      IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminal
      IPR036939 Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
      IPR001258 NHL repeat
      IPR000720 Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase
      IPR008977 PHM/PNGase F domain superfamily
      IPR011042 Six-bladed beta-propeller, TolB-like
    • GlyGen
      P97467 1 site
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 11
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13129
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 11
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory