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Pcp2 Gene Detail
Summary
  • Symbol
    Pcp2
  • Name
    Purkinje cell protein 2 (L7)
  • Synonyms
    L7, Pcp-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97508
    NCBI Gene: 18545
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:3673371-3675545 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 1.92 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97508
 protein coding gene Chr8:3673369-3675547 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033311
 protein coding gene Chr8:568176-570366 (-)
A/J MGP_AJ_G0033294
 protein coding gene Chr8:539741-541901 (-)
AKR/J MGP_AKRJ_G0033225
 protein coding gene Chr8:567469-569643 (-)
BALB/cJ MGP_BALBcJ_G0033294
 protein coding gene Chr8:565176-567495 (-)
C3H/HeJ MGP_C3HHeJ_G0033008
 protein coding gene Chr8:580555-582789 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033804
 protein coding gene Chr8:610627-612801 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030777
 protein coding gene Chr8:489967-492180 (-)
CAST/EiJ MGP_CASTEiJ_G0032331
 protein coding gene Chr8:574978-577113 (-)
CBA/J MGP_CBAJ_G0032981
 protein coding gene Chr8:625133-627307 (-)
DBA/2J MGP_DBA2J_G0033135
 protein coding gene Chr8:510210-512384 (-)
FVB/NJ MGP_FVBNJ_G0033082
 protein coding gene Chr8:559041-561203 (-)
LP/J MGP_LPJ_G0033227
 protein coding gene Chr8:552771-554931 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033117
 protein coding gene Chr8:605189-607363 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033822
 protein coding gene Chr8:561574-563745 (-)
PWK/PhJ MGP_PWKPhJ_G0032041
 protein coding gene Chr8:538062-540256 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031885
 protein coding gene Chr8:550692-552869 (-)
WSB/EiJ MGP_WSBEiJ_G0032444
 protein coding gene Chr8:556541-558714 (-)



Homology
more
  • Human Ortholog
    PCP2, Purkinje cell protein 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCP2, Purkinje cell protein 2
  • Synonyms
    GPSM4, PCD5
  • Links
    NCBI Gene ID: 126006
    neXtProt AC: NX_Q8IVA1
    UniProt: Q8IVA1

  • Chr Location
    19p13.2; chr19:7631611-7637006 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    28 phenotype references
Mice homozygous for a null mutation do not exhibit any detectable abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    38
  • cDNA Data
    12
  • Literature Summary
    16
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004630 Ensembl Gene Model | MGI Sequence Detail 2175 C57BL/6J ±  kb
transcript ENSMUST00000136105 Ensembl | MGI Sequence Detail 504 Not Applicable  
polypeptide ENSMUSP00000121079 Ensembl | MGI Sequence Detail 136 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 2
    cDNA 13
    Primer pair 4
    Other 2

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-13183, MGD-MRK-13186
References
more
  • Summaries
    All 78
    Developmental Gene Expression 16
    Gene Ontology 4
    Phenotypes 28
  • Earliest
    J:9499 Nordquist DT, et al., cDNA cloning and characterization of three genes uniquely expressed in cerebellum by Purkinje neurons. J Neurosci. 1988 Dec;8(12):4780-9
  • Latest
    J:316423 Whittaker DE, et al., A recessive PRDM13 mutation results in congenital hypogonadotropic hypogonadism and cerebellar hypoplasia. J Clin Invest. 2021 Dec 15;131(24):e141587
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory