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Pepd Gene Detail
Summary
  • Symbol
    Pepd
  • Name
    peptidase D
  • Synonyms
    dal, Pep-4, Pep4, peptidase D
  • Feature Type
    protein coding gene
  • IDs
    MGI:97542
    NCBI Gene: 18624
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:34611832-34744131 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 20.70 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3544 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97542
 protein coding gene Chr7:34611804-34744133 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032080
 protein coding gene Chr7:34259462-34393488 (+)
A/J MGP_AJ_G0032060
 protein coding gene Chr7:33358269-33490815 (+)
AKR/J MGP_AKRJ_G0031993
 protein coding gene Chr7:34155784-34293420 (+)
BALB/cJ MGP_BALBcJ_G0032067
 protein coding gene Chr7:33653321-33787417 (+)
C3H/HeJ MGP_C3HHeJ_G0031784
 protein coding gene Chr7:35051659-35187996 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032544
 protein coding gene Chr7:35957356-36097533 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029577
 protein coding gene Chr7:34080229-34213956 (+)
CAST/EiJ MGP_CASTEiJ_G0031119
 protein coding gene Chr7:26187360-26325131 (+)
CBA/J MGP_CBAJ_G0031752
 protein coding gene Chr7:37082812-37232680 (+)
DBA/2J MGP_DBA2J_G0031904
 protein coding gene Chr7:33201453-33335055 (+)
FVB/NJ MGP_FVBNJ_G0031859
 protein coding gene Chr7:33127867-33265377 (+)
LP/J MGP_LPJ_G0031981
 protein coding gene Chr7:34594463-34730505 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031897
 protein coding gene Chr7:36113442-36253108 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032559
 protein coding gene Chr7:33695235-33830139 (+)
PWK/PhJ MGP_PWKPhJ_G0030841
 protein coding gene Chr7:26530756-26664049 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030676
 protein coding gene Chr7:23271104-23412746 (+)
WSB/EiJ MGP_WSBEiJ_G0031229
 protein coding gene Chr7:34245574-34384917 (+)



Homology
more
  • Human Ortholog
    PEPD, peptidase D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEPD, peptidase D
  • Synonyms
    PROLIDASE
  • Links
    NCBI Gene ID: 5184
    neXtProt AC: NX_P12955
    UniProt: P12955

  • Chr Location
    19q13.11; chr19:33386950-33521823 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pepd mouse models; 1 with human PEPD associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    67 phenotypes from 3 alleles in 6 genetic backgrounds
    7 phenotypes from multigenic genotypes
    2 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants are smaller than normal siblings and, except on the flanks, an agouti coat appears nonagouti.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    902
  • Tissues
    99
  • cDNA Data
    108
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18624 NCBI Gene Model | MGI Sequence Detail 132300 C57BL/6J ±  kb
    transcript NM_008820 RefSeq | MGI Sequence Detail 1851 ZRU/MplStud  
    polypeptide Q11136 UniProt | EBI | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 1
      cDNA 108
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13234, MGD-MRK-13239, MGI:1934634
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:5133 Lewis WH, et al., Electrophoretic heterogeneity of mouse erythrocyte peptidases. Biochem Genet. 1969 Oct;3(5):493-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory