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Phb1 Gene Detail
Summary
  • Symbol
    Phb1
  • Name
    prohibitin 1
  • Synonyms
    Phb
  • Feature Type
    protein coding gene
  • IDs
    MGI:97572
    NCBI Gene: 18673
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:95557783-95571599 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.01 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    505 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97572
 protein coding gene Chr11:95557783-95571599 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018986
 protein coding gene Chr11:97879296-97898120 (+)
A/J MGP_AJ_G0018954
 protein coding gene Chr11:93934185-93950435 (+)
AKR/J MGP_AKRJ_G0018924
 protein coding gene Chr11:96837788-96853493 (+)
BALB/cJ MGP_BALBcJ_G0018927
 protein coding gene Chr11:94414310-94429240 (+)
C3H/HeJ MGP_C3HHeJ_G0018741
 protein coding gene Chr11:96962514-96979360 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019379
 protein coding gene Chr11:100954387-100972683 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017010
 protein coding gene Chr11:91416715-91428169 (+)
CAST/EiJ MGP_CASTEiJ_G0018295
 protein coding gene Chr11:97777278-97791275 (+)
CBA/J MGP_CBAJ_G0018712
 protein coding gene Chr11:105080579-105099736 (+)
DBA/2J MGP_DBA2J_G0018820
 protein coding gene Chr11:93503982-93519500 (+)
FVB/NJ MGP_FVBNJ_G0018809
 protein coding gene Chr11:92976758-92995391 (+)
LP/J MGP_LPJ_G0018890
 protein coding gene Chr11:98452214-98466025 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018836
 protein coding gene Chr11:105108808-105127558 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019419
 protein coding gene Chr11:97111182-97130973 (+)
PWK/PhJ MGP_PWKPhJ_G0018066
 protein coding gene Chr11:94443137-94457734 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017855
 protein coding gene Chr11:96798862-96820944 (+)
WSB/EiJ MGP_WSBEiJ_G0018344
 protein coding gene Chr11:97026248-97046112 (+)



Homology
more
  • Human Ortholog
    PHB1, prohibitin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHB1, prohibitin 1
  • Synonyms
    BAP32, HEL-215, HEL-S-54e, PHB
  • Links
    NCBI Gene ID: 5245
    neXtProt AC: NX_P35232
    UniProt: P35232

  • Chr Location
    17q21.33; chr17:49404049-49414905 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PHB1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 7 alleles in 4 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit early embryonic lethality while heterozygotes exhibit altered mammary gland development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    123
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    5
  • cDNA Data
    169
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18673 NCBI Gene Model | MGI Sequence Detail 13817 C57BL/6J ±  kb
    transcript NM_008831 RefSeq | MGI Sequence Detail 1756 C57BL/6  
    polypeptide P67778 UniProt | EBI | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 171
      Genomic 1
      cDNA 169
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13290, MGI:7484190
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 7
      Gene Ontology 20
      Phenotypes 31
    • Earliest
      J:3097 White JJ, et al., Assignment of the human prohibitin gene (PHB) to chromosome 17 and identification of a DNA polymorphism [published erratum appears in Genomics 1991 Nov;11(3):782]. Genomics. 1991 Sep;11(1):228-30
    • Latest
      J:345844 Guo Y, et al., Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther. 2024 Feb 14;9(1):32
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory