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Pim1 Gene Detail
Summary
  • Symbol
    Pim1
  • Name
    proviral integration site 1
  • Synonyms
    Pim-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97584
    NCBI Gene: 18712
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:29709759-29715085 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.38 cM
  • Mapping Data
    82 experiments
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97584
 protein coding gene Chr17:29709727-29715086 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023465
 protein coding gene Chr17:29030620-29036855 (+)
A/J MGP_AJ_G0023423
 protein coding gene Chr17:28053598-28058549 (+)
AKR/J MGP_AKRJ_G0023388
 protein coding gene Chr17:28280488-28285778 (+)
BALB/cJ MGP_BALBcJ_G0023428
 protein coding gene Chr17:28293155-28299613 (+)
C3H/HeJ MGP_C3HHeJ_G0023189
 protein coding gene Chr17:28656527-28661811 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023870
 protein coding gene Chr17:30168767-30175969 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021345
 protein coding gene Chr17:25354925-25360171 (+)
CAST/EiJ MGP_CASTEiJ_G0022690
 protein coding gene Chr17:28639315-28642952 (+)
CBA/J MGP_CBAJ_G0023164
 protein coding gene Chr17:31322085-31327032 (+)
DBA/2J MGP_DBA2J_G0023294
 protein coding gene Chr17:27558039-27563318 (+)
FVB/NJ MGP_FVBNJ_G0023264
 protein coding gene Chr17:27394377-27399884 (+)
LP/J MGP_LPJ_G0023372
 protein coding gene Chr17:29286692-29292832 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023282
 protein coding gene Chr17:30637468-30643972 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023912
 protein coding gene Chr17:28735184-28740581 (+)
PWK/PhJ MGP_PWKPhJ_G0022440
 protein coding gene Chr17:26399284-26404630 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022258
 protein coding gene Chr17:26722064-26727218 (+)
WSB/EiJ MGP_WSBEiJ_G0022752
 protein coding gene Chr17:28699783-28706296 (+)



Homology
more
  • Human Ortholog
    PIM1, Pim-1 proto-oncogene, serine/threonine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIM1, Pim-1 proto-oncogene, serine/threonine kinase
  • Synonyms
    PIM
  • Links
    NCBI Gene ID: 5292
    neXtProt AC: NX_P11309
    UniProt: P11309

  • Chr Location
    6p21.2; chr6:37170152-37175428 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 4 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have abnormally small erythrocytes but are otherwise phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    77
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    43
  • cDNA Data
    12
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18712 NCBI Gene Model | MGI Sequence Detail 5327 C57BL/6J ±  kb
    transcript NM_008842 RefSeq | MGI Sequence Detail 2665 ZRU/MplStud  
    polypeptide P06803 UniProt | EBI | MGI Sequence Detail 313 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 18
      cDNA 13
      Primer pair 3
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13306, MGD-MRK-13310
    References
    more
    • Summaries
      All 189
      Developmental Gene Expression 9
      Gene Ontology 13
      Phenotypes 58
    • Earliest
      J:7438 Cuypers HT, et al., Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cell. 1984 May;37(1):141-50
    • Latest
      J:346092 Lim PX, et al., BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair. Mol Cell. 2024 Feb 1;84(3):447-462.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory