Prkcg MGI Mouse Gene Detail - MGI:97597

Symbol

Prkcg
Name

protein kinase C, gamma
Synonyms

Pkcc, PKCgamma, Prkcc

Feature Type

protein coding gene
IDs

MGI:97597
NCBI Gene: 18752
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:3352038-3379615 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 1.93 cM
Mapping Data

31 experiments

SNPs within 2kb

171 from dbSNP Build 142
Strain Annotations

18
RFLP

7

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97597	protein coding gene	Chr7:3337704-3379615 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031516	protein coding gene	Chr7:187054-233297 (+)
A/J	MGP_AJ_G0031491	protein coding gene	Chr7:196944-238862 (+)
AKR/J	MGP_AKRJ_G0031419	protein coding gene	Chr7:188588-230546 (+)
BALB/cJ	MGP_BALBcJ_G0031499	protein coding gene	Chr7:194532-237383 (+)
C3H/HeJ	MGP_C3HHeJ_G0031219	protein coding gene	Chr7:190307-234073 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031959	protein coding gene	Chr7:193717-236931 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029086	protein coding gene	Chr7:94056-137037 (+)
CAST/EiJ	MGP_CASTEiJ_G0030588	protein coding gene	Chr7:194408-239155 (+)
CBA/J	MGP_CBAJ_G0031179	protein coding gene	Chr7:267484-322766 (+)
DBA/2J	MGP_DBA2J_G0031336	protein coding gene	Chr7:181780-228441 (+)
FVB/NJ	MGP_FVBNJ_G0031288	protein coding gene	Chr7:186372-230158 (+)
LP/J	MGP_LPJ_G0031421	protein coding gene	Chr7:186652-232418 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031327	protein coding gene	Chr7:213361-256251 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031993	protein coding gene	Chr7:166740-209767 (+)
PWK/PhJ	MGP_PWKPhJ_G0030315	protein coding gene	Chr7:328254-370962 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030139	protein coding gene	Chr7:259292-305076 (+)
WSB/EiJ	MGP_WSBEiJ_G0030682	protein coding gene	Chr7:180965-226813 (+)

Human Ortholog

PRKCG, protein kinase C gamma

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRKCG, protein kinase C gamma
Synonyms

PKCC, PKCG, PKC-gamma, PKCgamma, PKCI(3), SCA14
Links

HGNC:9402

NCBI Gene ID: 5582

neXtProt AC: NX_P05129

UniProt: P05129
Chr Location

19q13.42; chr19:53879190-53907652 (+) GRCh38

MGI Vertebrate Homology

Prkcg stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRKCG
Protein SuperFamily

PKC_alpha
Gene Tree

Prkcg

Diseases

1 with Prkcg mouse models; 1 with human PRKCG associations

Human Disease

Mouse Models

spinocerebellar ataxia type 14

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

22 phenotypes from 3 alleles in 9 genetic backgrounds
59 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

6
Gene trapped

2
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Depending upon genetic background, homozygous null mice show mild deficits in spatial learning and contextual conditioning. Genotype-dependent reductions in sensitivity to the effects of ethanol on righting reflex and hypothermia, in neuropathic pain after injury, and in anxiety are also evident.

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All GO Annotations

62
GO References

24

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

873
Tissues

83
cDNA Data

25
Literature Summary

61

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prkcg

ZFIN prkcg

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All Sequences

48
RefSeq

8
UniProt

4
CCDS

CCDS57470.1, CCDS80649.1

Ensembl

ENSMUSG00000078816 (Evidence)
NCBI Gene

18752

			Length	Strain/Species	Flank
genomic	18752	NCBI Gene Model \| MGI Sequence Detail	27578	C57BL/6J	± kb
transcript	NM_011102	RefSeq \| MGI Sequence Detail	3127	ZRU/MplStud
polypeptide	P63318	UniProt \| EBI \| MGI Sequence Detail	697	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003060 protein kinase C gamma type

(term hierarchy)
EC

2.7.11.13
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR046349 C1-like domain superfamily

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR020454 Diacylglycerol/phorbol-ester binding

IPR017441 Protein kinase, ATP binding site

IPR014375 Protein kinase C, alpha/beta/gamma types

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

P63318 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 36

Genomic 3

cDNA 28

Primer pair 4

Other 1

Microarray probesets 2

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MGD-MRK-13329

Summaries

All 209

Developmental Gene Expression 61

Diseases 1

Gene Ontology 24

Phenotypes 59
Earliest

J:10128 Wada H, et al., Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun. 1989 Nov 30;165(1):533-8
Latest

J:348700 Hu L, et al., Ventricular Netrin-1 deficiency leads to defective pyramidal decussation and mirror movement in mice. Cell Death Dis. 2024 May 17;15(5):343

TSS for Prkcg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64245	Chr7:3378769-3378779 (+)	26,736 bp
Tssr64246	Chr7:3378891-3378907 (+)	26,861 bp
Tssr64247	Chr7:3379069-3379082 (+)	27,038 bp
Tssr2064	Chr7:3379320-3379332 (+)	27,288 bp
Tssr2065	Chr7:3379399-3379413 (+)	27,368 bp
Tssr2066	Chr7:3379417-3379437 (+)	27,389 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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