About   Help   FAQ
Prkcd Gene Detail
Summary
  • Symbol
    Prkcd
  • Name
    protein kinase C, delta
  • Synonyms
    D14Ertd420e, Pkcd, PKC[d], PKCdelta
  • Feature Type
    protein coding gene
  • IDs
    MGI:97598
    NCBI Gene: 18753
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:30317311-30348167 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 18.82 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    759 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97598
 protein coding gene Chr14:30317310-30348637 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021105
 protein coding gene Chr14:23723287-23757163 (-)
A/J MGP_AJ_G0021053
 protein coding gene Chr14:22846183-22877878 (-)
AKR/J MGP_AKRJ_G0021030
 protein coding gene Chr14:23955641-23986516 (-)
BALB/cJ MGP_BALBcJ_G0021057
 protein coding gene Chr14:22945037-22976391 (-)
C3H/HeJ MGP_C3HHeJ_G0020840
 protein coding gene Chr14:23812423-23844317 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021489
 protein coding gene Chr14:24668553-24704221 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019052
 protein coding gene Chr14:22903704-22934171 (-)
CAST/EiJ MGP_CASTEiJ_G0020365
 protein coding gene Chr14:23550786-23582184 (-)
CBA/J MGP_CBAJ_G0020807
 protein coding gene Chr14:25626139-25659393 (-)
DBA/2J MGP_DBA2J_G0020929
 protein coding gene Chr14:22874686-22906697 (-)
FVB/NJ MGP_FVBNJ_G0020913
 protein coding gene Chr14:22833543-22864429 (-)
LP/J MGP_LPJ_G0020998
 protein coding gene Chr14:24051554-24081970 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020939
 protein coding gene Chr14:24915189-24948283 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021522
 protein coding gene Chr14:23702089-23732847 (-)
PWK/PhJ MGP_PWKPhJ_G0020113
 protein coding gene Chr14:22311869-22344605 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019937
 protein coding gene Chr14:23291607-23322919 (-)
WSB/EiJ MGP_WSBEiJ_G0020420
 protein coding gene Chr14:23760428-23794436 (-)



Homology
more
  • Human Ortholog
    PRKCD, protein kinase C delta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKCD, protein kinase C delta
  • Synonyms
    ALPS3, CVID9, MAY1, nPKC-delta, PKCD
  • Links
    NCBI Gene ID: 5580
    neXtProt AC: NX_Q05655
    UniProt: Q05655

  • Chr Location
    3p21.1; chr3:53156009-53192717 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PRKCD associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 7 alleles in 8 genetic backgrounds
    21 phenotypes from multigenic genotypes
    1 images
    112 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased neutrophil cell numbers and activity, increased B cell numbers and proliferation, increased acute inflammation, and increased IgG1 and IgA serum levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    114
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1004
  • Tissues
    176
  • cDNA Data
    76
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021948 Ensembl Gene Model | MGI Sequence Detail 30857 C57BL/6J ±  kb
    transcript ENSMUST00000022521 Ensembl | MGI Sequence Detail 2612 Not Applicable  
    polypeptide ENSMUSP00000022521 Ensembl | MGI Sequence Detail 700 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 77
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13330, MGI:1196301, MGI:2145627
    References
    more
    • Summaries
      All 274
      Developmental Gene Expression 29
      Gene Ontology 21
      Phenotypes 112
    • Earliest
      J:2328 Mizuno K, et al., Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta. Eur J Biochem. 1991 Dec 18;202(3):931-40
    • Latest
      J:353466 Colgan LA, et al., Dual Regulation of Spine-Specific and Synapse-to-Nucleus Signaling by PKCdelta during Plasticity. J Neurosci. 2023 Jul 26;43(30):5432-5447
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory