Prkce MGI Mouse Gene Detail - MGI:97599 - protein kinase C, epsilon

Symbol

Prkce
Name

protein kinase C, epsilon
Synonyms

5830406C15Rik, PCK epsilon, Pkce, PKC[e], PKCepsilon

Feature Type

protein coding gene
IDs

MGI:97599
NCBI Gene: 18754
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr17:86475213-86965347 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 56.74 cM
Mapping Data

2 experiments

SNPs within 2kb

15853 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97599	protein coding gene	Chr17:86472631-86965347 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024091	protein coding gene	Chr17:89472074-89986091 (+)
A/J	MGP_AJ_G0024050	protein coding gene	Chr17:86594434-87094832 (+)
AKR/J	MGP_AKRJ_G0024019	protein coding gene	Chr17:88011182-88533885 (+)
BALB/cJ	MGP_BALBcJ_G0024051	protein coding gene	Chr17:86442035-86941020 (+)
C3H/HeJ	MGP_C3HHeJ_G0023816	protein coding gene	Chr17:88897745-89401399 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024496	protein coding gene	Chr17:92591410-93113232 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021935	protein coding gene	Chr17:81779881-82262257 (+)
CAST/EiJ	MGP_CASTEiJ_G0023295	protein coding gene	Chr17:89713927-90248352 (+)
CBA/J	MGP_CBAJ_G0023790	protein coding gene	Chr17:96447618-97004324 (+)
DBA/2J	MGP_DBA2J_G0023918	protein coding gene	Chr17:85054484-85547089 (+)
FVB/NJ	MGP_FVBNJ_G0023884	protein coding gene	Chr17:84547877-85041588 (+)
LP/J	MGP_LPJ_G0024002	protein coding gene	Chr17:90232339-90767373 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023912	protein coding gene	Chr17:96426635-96945655 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024541	protein coding gene	Chr17:88540253-89060399 (+)
PWK/PhJ	MGP_PWKPhJ_G0023040	protein coding gene	Chr17:84666636-85168715 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022851	protein coding gene	Chr17:85325485-85862735 (+)
WSB/EiJ	MGP_WSBEiJ_G0023361	protein coding gene	Chr17:89389892-89915073 (+)

Human Ortholog

PRKCE, protein kinase C epsilon

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRKCE, protein kinase C epsilon
Synonyms

nPKC-epsilon, PKCE
Links

HGNC:9401

NCBI Gene ID: 5581

neXtProt AC: NX_Q02156

UniProt: Q02156
Chr Location

2p21; chr2:45651279-46187990 (+) GRCh38

MGI Vertebrate Homology

Prkce stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PRKCE
Protein SuperFamily

PKC_delta
Gene Tree

Prkce

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Phenotype Summary

16 phenotypes from 4 alleles in 4 genetic backgrounds
2 phenotypes from multigenic genotypes
95 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (ENU)

1
Endonuclease-mediated

5
Gene trapped

1
Targeted

8
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit reduced ethanol self-administration and are more sensitive to the acute behavioral effects of ethanol and other drugs that activate GABA(A) receptors. Mutants show reduced anxiety and stress hormones.

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All GO Annotations

105
GO References

39

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1002
Tissues

111
cDNA Data

51
Literature Summary

22

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prkce

ZFIN prkcea

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All Sequences

44
RefSeq

8
UniProt

2
CCDS

CCDS29008.1

Ensembl

ENSMUSG00000045038 (Evidence)
NCBI Gene

18754

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045038	Ensembl Gene Model \| MGI Sequence Detail	490135	C57BL/6J	± kb
transcript	ENSMUST00000097274	Ensembl \| MGI Sequence Detail	3161	Not Applicable
polypeptide	ENSMUSP00000094873	Ensembl \| MGI Sequence Detail	737	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000002342 protein kinase C epsilon

(term hierarchy)
EC

2.7.11.13
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR046349 C1-like domain superfamily

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR020454 Diacylglycerol/phorbol-ester binding

IPR052981 Ingression C2 domain-containing protein

IPR034669 Novel protein kinase C epsilon, catalytic domain

IPR017441 Protein kinase, ATP binding site

IPR014376 Protein kinase C, delta/epsilon/eta/theta types

IPR027274 Protein kinase C, epsilon

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

P16054 1 site, 1 O-linked glycan (1 site)

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All nucleic 54

cDNA 54

Microarray probesets 5

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MGD-MRK-13331, MGI:1914847, MGI:2147156

Summaries

All 233

Developmental Gene Expression 22

Gene Ontology 39

Phenotypes 95
Earliest

J:10128 Wada H, et al., Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun. 1989 Nov 30;165(1):533-8
Latest

J:353466 Colgan LA, et al., Dual Regulation of Spine-Specific and Synapse-to-Nucleus Signaling by PKCdelta during Plasticity. J Neurosci. 2023 Jul 26;43(30):5432-5447

TSS for Prkce:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146103	Chr17:86475025-86475045 (+)	-178 bp
Tssr146104	Chr17:86475048-86475111 (+)	-133 bp
Tssr146105	Chr17:86475205-86475223 (+)	1 bp
Tssr146106	Chr17:86475246-86475253 (+)	37 bp
Tssr146107	Chr17:86475852-86475867 (+)	647 bp
Tssr5224	Chr17:86531002-86531019 (+)	55,798 bp
Tssr146108	Chr17:86531108-86531119 (+)	55,901 bp
Tssr146109	Chr17:86540170-86540181 (+)	64,963 bp
Tssr146110	Chr17:86646010-86646023 (+)	170,804 bp
Tssr146111	Chr17:86646030-86646041 (+)	170,823 bp
Tssr146112	Chr17:86667749-86667763 (+)	192,543 bp
Tssr146113	Chr17:86731609-86731639 (+)	256,411 bp
Tssr146114	Chr17:86736226-86736257 (+)	261,029 bp
Tssr146115	Chr17:86746445-86746458 (+)	271,239 bp
Tssr146116	Chr17:86964121-86964126 (+)	488,911 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24