Plcg1 MGI Mouse Gene Detail - MGI:97615 - phospholipase C, gamma 1

Symbol

Plcg1
Name

phospholipase C, gamma 1
Synonyms

Cded, Plc-1, Plcg-1, Plc-gamma1

Feature Type

protein coding gene
IDs

MGI:97615
NCBI Gene: 18803
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr2:160573230-160617680 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 80.97 cM
Mapping Data

12 experiments

SNPs within 2kb

829 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97615	protein coding gene	Chr2:160573220-160617680 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026806	protein coding gene	Chr2:165932388-165976874 (+)
A/J	MGP_AJ_G0026772	protein coding gene	Chr2:159261722-159306369 (+)
AKR/J	MGP_AKRJ_G0026743	protein coding gene	Chr2:163974225-164018663 (+)
BALB/cJ	MGP_BALBcJ_G0026781	protein coding gene	Chr2:159576892-159621351 (+)
C3H/HeJ	MGP_C3HHeJ_G0026523	protein coding gene	Chr2:164299787-164344429 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027230	protein coding gene	Chr2:170844863-170890942 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024600	protein coding gene	Chr2:152634888-152679467 (+)
CAST/EiJ	MGP_CASTEiJ_G0025985	protein coding gene	Chr2:164674513-164734692 (+)
CBA/J	MGP_CBAJ_G0026500	protein coding gene	Chr2:176970715-177015156 (+)
DBA/2J	MGP_DBA2J_G0026638	protein coding gene	Chr2:158446673-158491153 (+)
FVB/NJ	MGP_FVBNJ_G0026605	protein coding gene	Chr2:156844581-156889291 (+)
LP/J	MGP_LPJ_G0026741	protein coding gene	Chr2:166038589-166083082 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026626	protein coding gene	Chr2:180692944-180739242 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027286	protein coding gene	Chr2:163809175-163853584 (+)
PWK/PhJ	MGP_PWKPhJ_G0025719	protein coding gene	Chr2:157993927-158039372 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025522	protein coding gene	Chr2:162699114-162743312 (+)
WSB/EiJ	MGP_WSBEiJ_G0026055	protein coding gene	Chr2:164705821-164750249 (+)

Human Ortholog

PLCG1, phospholipase C gamma 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLCG1, phospholipase C gamma 1
Synonyms

IDAA, NCKAP3, PLC1, PLC148, PLCgamma1, PLC-II
Links

HGNC:9065

NCBI Gene ID: 5335

neXtProt AC: NX_P19174

UniProt: P19174
Chr Location

20q12; chr20:41136960-41196801 (+) GRCh38

MGI Vertebrate Homology

Plcg1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLCG1
Protein SuperFamily

PLC-gamma
Gene Tree

Plcg1

Diseases

2 with human PLCG1 associations

				Human Disease	Mouse Models
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 4 alleles in 5 genetic backgrounds
20 phenotypes from multigenic genotypes
1 images
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

1
Gene trapped

4
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit early embryonic lethality associated with arrested growth and/or abnormal hematopoiesis.

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All GO Annotations

86
GO References

25

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

924
Tissues

196
cDNA Data

18
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plcg1

ZFIN plcg1

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All Sequences

62
RefSeq

2
UniProt

9
CCDS

CCDS16996.1

Ensembl

ENSMUSG00000016933 (Evidence)
NCBI Gene

18803

			Length	Strain/Species	Flank
genomic	18803	NCBI Gene Model \| MGI Sequence Detail	44451	C57BL/6J	± kb
transcript	NM_021280	RefSeq \| MGI Sequence Detail	4435	ZRU/MplStud
polypeptide	Q62077	UniProt \| EBI \| MGI Sequence Detail	1302	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000012836 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

(term hierarchy)
EC

3.1.4.11
InterPro Domains

IPR035724 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR011993 PH-like domain superfamily

IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma

IPR000909 Phosphatidylinositol-specific phospholipase C, X domain

IPR001192 Phosphoinositide phospholipase C family

IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain

IPR035023 PLC-gamma, C-terminal SH2 domain

IPR035024 PLC-gamma, N-terminal SH2 domain

IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

IPR001849 Pleckstrin homology domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

Q62077 1 site, 1 O-linked glycan (1 site)

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All nucleic 34

Genomic 8

cDNA 18

Primer pair 6

Other 2

Microarray probesets 5

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MGD-MRK-13350, MGD-MRK-13353, MGD-MRK-13355, MGI:1329022, MGI:2139113

Summaries

All 165

Developmental Gene Expression 25

Gene Ontology 25

Phenotypes 28
Earliest

J:27510 Reith AD, et al., Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. EMBO J. 1991 Sep;10(9):2451-9
Latest

J:348282 Ju H, et al., Gestational diabetes mellitus induces congenital anomalies of the kidney and urinary tract in mice by altering RET/MAPK/ERK pathway. Biochem Biophys Res Commun. 2024 Jun 25;714:149959

TSS for Plcg1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21399	Chr2:160573178-160573220 (+)	-31 bp
Tssr21400	Chr2:160573604-160573680 (+)	412 bp
Tssr21401	Chr2:160573696-160573716 (+)	476 bp
Tssr21402	Chr2:160574555-160574558 (+)	1,327 bp
Tssr21403	Chr2:160582911-160582918 (+)	9,685 bp
Tssr21404	Chr2:160589249-160589261 (+)	16,025 bp
Tssr21405	Chr2:160589292-160589307 (+)	16,070 bp
Tssr21406	Chr2:160599076-160599086 (+)	25,851 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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