Pnliprp1 Gene Detail

Summary

• Symbol
  Pnliprp1
• Name
  pancreatic lipase related protein 1
• Synonyms
  Plrp1

• Feature Type
  protein coding gene
• IDs
  MGI:97723
  NCBI Gene: 18946
• Alliance
  gene page
• Transcription Start Sites
  29 TSS
• Candidate for QTL
  6 QTL

Location &
Maps

• Sequence Map
  Chr19:58717319-58732601 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 19, 54.49 cM
• Mapping Data
  7 experiments

Strain
Comparison

• SNPs within 2kb
  467 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  2

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97723	protein coding gene	Chr19:58717319-58732601 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025279	protein coding gene	Chr19:59216381-59231590 (+)
A/J	MGP_AJ_G0025255	protein coding gene	Chr19:56317239-56332459 (+)
AKR/J	MGP_AKRJ_G0025224	protein coding gene	Chr19:58075115-58090317 (+)
BALB/cJ	MGP_BALBcJ_G0025250	protein coding gene	Chr19:56382491-56397717 (+)
C3H/HeJ	MGP_C3HHeJ_G0025010	protein coding gene	Chr19:58324241-58339452 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025693	protein coding gene	Chr19:60642858-60658138 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023105	protein coding gene	Chr19:55190686-55205393 (+)
CAST/EiJ	MGP_CASTEiJ_G0024475	protein coding gene	Chr19:58398581-58413196 (+)
CBA/J	MGP_CBAJ_G0024990	protein coding gene	Chr19:63603671-63619024 (+)
DBA/2J	MGP_DBA2J_G0025122	protein coding gene	Chr19:56060577-56076110 (+)
FVB/NJ	MGP_FVBNJ_G0025083	protein coding gene	Chr19:55797505-55813460 (+)
LP/J	MGP_LPJ_G0025208	protein coding gene	Chr19:59080021-59095240 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025116	protein coding gene	Chr19:62850558-62866692 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025751	protein coding gene	Chr19:58307129-58322341 (+)
PWK/PhJ	MGP_PWKPhJ_G0024223	protein coding gene	Chr19:56065394-56080743 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024026	protein coding gene	Chr19:56969101-56983890 (+)
WSB/EiJ	MGP_WSBEiJ_G0024545	protein coding gene	Chr19:58426698-58443786 (+)

Homology

• Human Ortholog
  PNLIPRP1, pancreatic lipase related protein 1

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  PNLIPRP1, pancreatic lipase related protein 1
  
• Synonyms
  PLRP1
• Links
  HGNC:9156

  NCBI Gene ID: 5407

  neXtProt AC: NX_P54315

  UniProt: P54315

  
  
• Chr Location
  10q25.3; chr10:116590385-116609175 (+)  GRCh38

---

• MGI Vertebrate Homology
  Pnliprp1 stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: PNLIPRP1
• Protein SuperFamily
  Lipoprotein_lipase_LIPH
• Gene Tree
  Pnliprp1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  12 phenotypes from 1 allele in 1 genetic background
  4 phenotype references
  

• All Mutations and Alleles
  4
• Endonuclease-mediated
  1
• Targeted
  3
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  31 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a knock-out allele show increased lipase activity in pancreatic juice and develop obesity associated with increased body fat mass, impaired glucose tolerance and insulin resistance, with these conditions exacerbated on a high-fat diet.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  12
• GO References
  5

Expression

• Assay Results
  814
• Tissues
  96
• cDNA Data
  597
• Literature Summary
  5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase pnliprp1

Sequences &
Gene Models

• All Sequences
  39
• RefSeq
  2
• UniProt
  3
• CCDS
  CCDS29931.1

• Ensembl
  ENSMUSG00000042179 (Evidence)
• NCBI Gene
  18946

Representative Sequences			Length	Strain/Species
genomic	18946	NCBI Gene Model | MGI Sequence Detail	15283	C57BL/6J
transcript	NM_018874	RefSeq | MGI Sequence Detail	1619	Swiss Webster
polypeptide	Q5BKQ4	UniProt | EBI | MGI Sequence Detail	473	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000012926 pancreatic lipase-related protein 1
  (term hierarchy)
• InterPro Domains
  IPR029058 Alpha/Beta hydrolase fold
  IPR013818 Lipase
  IPR016272 Lipase, LIPH-type
  IPR033906 Lipase, N-terminal
  IPR002331 Pancreatic lipase
  IPR001024 PLAT/LH2 domain
  IPR036392 PLAT/LH2 domain superfamily
  IPR000734 Triacylglycerol lipase family
• GlyGen
  Q5BKQ4 1 site, 1 N-linked glycan (1 site)

Molecular
Reagents

• All nucleic 599

  cDNA 598

  Other 1

  
  

  Microarray probesets 4

Other
Accession IDs

MGD-MRK-13545

References

• Summaries
  All 36

  Developmental Gene Expression 5

  Gene Ontology 5

  Phenotypes 4
• Earliest
  J:43376 Grusby MJ, et al., Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase. Cell. 1990 Feb 9;60(3):451-9
• Latest
  J:304253 Jones MR, et al., A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Front Genet. 2018;9:746

TSS for Pnliprp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157291	Chr19:58716438-58716447 (+)	-876 bp
Tssr157292	Chr19:58716492-58716501 (+)	-822 bp
Tssr157293	Chr19:58716561-58716595 (+)	-741 bp
Tssr157294	Chr19:58717396-58717413 (+)	86 bp
Tssr157295	Chr19:58717732-58717767 (+)	431 bp
Tssr157296	Chr19:58718323-58718334 (+)	1,010 bp
Tssr157297	Chr19:58718403-58718523 (+)	1,144 bp
Tssr157298	Chr19:58718898-58718995 (+)	1,628 bp
Tssr157299	Chr19:58720450-58720459 (+)	3,136 bp
Tssr157300	Chr19:58720463-58720484 (+)	3,155 bp
Tssr157301	Chr19:58720494-58720526 (+)	3,191 bp
Tssr157302	Chr19:58720532-58720553 (+)	3,224 bp
Tssr157303	Chr19:58721776-58721840 (+)	4,489 bp
Tssr157304	Chr19:58721851-58721868 (+)	4,541 bp
Tssr157305	Chr19:58723091-58723165 (+)	5,809 bp
Tssr157306	Chr19:58723324-58723383 (+)	6,035 bp
Tssr157307	Chr19:58725426-58725459 (+)	8,124 bp
Tssr157308	Chr19:58725460-58725477 (+)	8,150 bp
Tssr157309	Chr19:58725491-58725512 (+)	8,183 bp
Tssr157310	Chr19:58726567-58726688 (+)	9,309 bp
Tssr157311	Chr19:58726704-58726714 (+)	9,390 bp
Tssr157312	Chr19:58726735-58726744 (+)	9,421 bp
Tssr157313	Chr19:58726786-58726797 (+)	9,473 bp
Tssr157314	Chr19:58727877-58727883 (+)	10,561 bp
Tssr157320	Chr19:58732468-58732498 (+)	15,164 bp
Tssr157321	Chr19:58732504-58732526 (+)	15,196 bp
Tssr157322	Chr19:58732527-58732545 (+)	15,217 bp
Tssr157323	Chr19:58732546-58732557 (+)	15,233 bp
Tssr157324	Chr19:58732563-58732574 (+)	15,250 bp

Pnliprp1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Afw8	Chr19, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Iba4 (20 cM) on mouse Chromosome 19 as identified by ExQuest are Aldh1a1 (12 cM), Aldh1a7, Vldlr (20 cM), and Plce1. Vldlr exhibits 15.6-fold increased expression in the liver of Tally Ho compared to C57BL/6 animals. For QTL Afw8 (26 cM), potential candidate genes Pi4k2a, Cpn1, and Elovl3 (47 cM) were identified. For QTLs Nobq2 (47 cM) and Bglq13 (51 cM), potential candidate genes Ins1 (49 cM), Gpam (52 cM), and Acsl5 were identified. For QTLs Tanidd1 (50 cM) and T2dm2 (53 cM), potential candidate genes Gfra1, Pnlip (29 cM), Pnliprp1 (29 cM), and Pnliprp2 were identified. Pnliprp2 exhibits 21.8-fold decreased expression in the pancreas of Tally Ho animals in response to a 4% fat diet.
Bglq13	Chr19, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Iba4 (20 cM) on mouse Chromosome 19 as identified by ExQuest are Aldh1a1 (12 cM), Aldh1a7, Vldlr (20 cM), and Plce1. Vldlr exhibits 15.6-fold increased expression in the liver of Tally Ho compared to C57BL/6 animals. For QTL Afw8 (26 cM), potential candidate genes Pi4k2a, Cpn1, and Elovl3 (47 cM) were identified. For QTLs Nobq2 (47 cM) and Bglq13 (51 cM), potential candidate genes Ins1 (49 cM), Gpam (52 cM), and Acsl5 were identified. For QTLs Tanidd1 (50 cM) and T2dm2 (53 cM), potential candidate genes Gfra1, Pnlip (29 cM), Pnliprp1 (29 cM), and Pnliprp2 were identified. Pnliprp2 exhibits 21.8-fold decreased expression in the pancreas of Tally Ho animals in response to a 4% fat diet.
Iba4	Chr19, 20.99 cM	Chr19:26305715-26305821	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Iba4 (20 cM) on mouse Chromosome 19 as identified by ExQuest are Aldh1a1 (12 cM), Aldh1a7, Vldlr (20 cM), and Plce1. Vldlr exhibits 15.6-fold increased expression in the liver of Tally Ho compared to C57BL/6 animals. For QTL Afw8 (26 cM), potential candidate genes Pi4k2a, Cpn1, and Elovl3 (47 cM) were identified. For QTLs Nobq2 (47 cM) and Bglq13 (51 cM), potential candidate genes Ins1 (49 cM), Gpam (52 cM), and Acsl5 were identified. For QTLs Tanidd1 (50 cM) and T2dm2 (53 cM), potential candidate genes Gfra1, Pnlip (29 cM), Pnliprp1 (29 cM), and Pnliprp2 were identified. Pnliprp2 exhibits 21.8-fold decreased expression in the pancreas of Tally Ho animals in response to a 4% fat diet.
Nobq2	Chr19, 40.53 cM	Chr19:47897880-47897988	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Iba4 (20 cM) on mouse Chromosome 19 as identified by ExQuest are Aldh1a1 (12 cM), Aldh1a7, Vldlr (20 cM), and Plce1. Vldlr exhibits 15.6-fold increased expression in the liver of Tally Ho compared to C57BL/6 animals. For QTL Afw8 (26 cM), potential candidate genes Pi4k2a, Cpn1, and Elovl3 (47 cM) were identified. For QTLs Nobq2 (47 cM) and Bglq13 (51 cM), potential candidate genes Ins1 (49 cM), Gpam (52 cM), and Acsl5 were identified. For QTLs Tanidd1 (50 cM) and T2dm2 (53 cM), potential candidate genes Gfra1, Pnlip (29 cM), Pnliprp1 (29 cM), and Pnliprp2 were identified. Pnliprp2 exhibits 21.8-fold decreased expression in the pancreas of Tally Ho animals in response to a 4% fat diet.
T2dm2	Chr19, 50.72 cM	Chr19:55376050-55376167	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Iba4 (20 cM) on mouse Chromosome 19 as identified by ExQuest are Aldh1a1 (12 cM), Aldh1a7, Vldlr (20 cM), and Plce1. Vldlr exhibits 15.6-fold increased expression in the liver of Tally Ho compared to C57BL/6 animals. For QTL Afw8 (26 cM), potential candidate genes Pi4k2a, Cpn1, and Elovl3 (47 cM) were identified. For QTLs Nobq2 (47 cM) and Bglq13 (51 cM), potential candidate genes Ins1 (49 cM), Gpam (52 cM), and Acsl5 were identified. For QTLs Tanidd1 (50 cM) and T2dm2 (53 cM), potential candidate genes Gfra1, Pnlip (29 cM), Pnliprp1 (29 cM), and Pnliprp2 were identified. Pnliprp2 exhibits 21.8-fold decreased expression in the pancreas of Tally Ho animals in response to a 4% fat diet.
Tanidd1	Chr19, 48.46 cM	Chr19:53752597-53752718	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Iba4 (20 cM) on mouse Chromosome 19 as identified by ExQuest are Aldh1a1 (12 cM), Aldh1a7, Vldlr (20 cM), and Plce1. Vldlr exhibits 15.6-fold increased expression in the liver of Tally Ho compared to C57BL/6 animals. For QTL Afw8 (26 cM), potential candidate genes Pi4k2a, Cpn1, and Elovl3 (47 cM) were identified. For QTLs Nobq2 (47 cM) and Bglq13 (51 cM), potential candidate genes Ins1 (49 cM), Gpam (52 cM), and Acsl5 were identified. For QTLs Tanidd1 (50 cM) and T2dm2 (53 cM), potential candidate genes Gfra1, Pnlip (29 cM), Pnliprp1 (29 cM), and Pnliprp2 were identified. Pnliprp2 exhibits 21.8-fold decreased expression in the pancreas of Tally Ho animals in response to a 4% fat diet.

*cM position of peak correlated region/marker