Endou MGI Mouse Gene Detail - MGI:97746 - endonuclease, polyU-specific

Symbol

Endou
Name

endonuclease, polyU-specific
Synonyms

Pp11r, Tcl-30

Feature Type

protein coding gene
IDs

MGI:97746
NCBI Gene: 19011
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr15:97608896-97629220 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 53.70 cM
Mapping Data

2 experiments

SNPs within 2kb

798 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97746	protein coding gene	Chr15:97608896-97629286 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022277	protein coding gene	Chr15:99381191-99401578 (-)
A/J	MGP_AJ_G0022236	protein coding gene	Chr15:95450634-95471021 (-)
AKR/J	MGP_AKRJ_G0022211	protein coding gene	Chr15:98330259-98350647 (-)
BALB/cJ	MGP_BALBcJ_G0022242	protein coding gene	Chr15:95676378-95696764 (-)
C3H/HeJ	MGP_C3HHeJ_G0022012	protein coding gene	Chr15:98407512-98427871 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022687	protein coding gene	Chr15:103048786-103069206 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020213	protein coding gene	Chr15:91398779-91419425 (-)
CAST/EiJ	MGP_CASTEiJ_G0021534	protein coding gene	Chr15:99281829-99302898 (-)
CBA/J	MGP_CBAJ_G0021979	protein coding gene	Chr15:106512405-106532791 (-)
DBA/2J	MGP_DBA2J_G0022106	protein coding gene	Chr15:94903214-94923604 (-)
FVB/NJ	MGP_FVBNJ_G0022085	protein coding gene	Chr15:93891126-93911512 (-)
LP/J	MGP_LPJ_G0022177	protein coding gene	Chr15:99488582-99508972 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022105	protein coding gene	Chr15:110634290-110654680 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022702	protein coding gene	Chr15:98483758-98504137 (-)
PWK/PhJ	MGP_PWKPhJ_G0021275	protein coding gene	Chr15:95000576-95021033 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021109	protein coding gene	Chr15:98255204-98275904 (-)
WSB/EiJ	MGP_WSBEiJ_G0021583	protein coding gene	Chr15:99002522-99022882 (-)

Human Ortholog

ENDOU, endonuclease, poly(U) specific

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ENDOU, endonuclease, poly(U) specific
Synonyms

P11, PP11, PRSS26
Links

HGNC:14369

NCBI Gene ID: 8909

neXtProt AC: NX_P21128

UniProt: P21128
Chr Location

12q13.11; chr12:47709734-47725567 (-) GRCh38

MGI Vertebrate Homology

Endou stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ENDOU
Gene Tree

Endou

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Endou
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit normal splenic B cell numbers and activation-induced B cell apoptosis.

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All GO Annotations

24
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

6
cDNA Data

27
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase endou, endoul

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All Sequences

42
RefSeq

10
UniProt

2
CCDS

CCDS27783.1, CCDS49712.1

Ensembl

ENSMUSG00000022468 (Evidence)
NCBI Gene

19011

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022468	Ensembl Gene Model \| MGI Sequence Detail	20325	C57BL/6J	± kb
transcript	ENSMUST00000023105	Ensembl \| MGI Sequence Detail	2408	Not Applicable
polypeptide	ENSMUSP00000023105	Ensembl \| MGI Sequence Detail	454	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030363 uridylate-specific endoribonuclease

(term hierarchy)
EC

4.6.1.-
InterPro Domains

IPR037227 Endoribonuclease EndoU-like

IPR018998 EndoU ribonuclease, C-terminal

IPR039787 Poly(U)-specific endoribonuclease

IPR001212 Somatomedin B domain

IPR020436 Somatomedin B domain, chordata

IPR036024 Somatomedin B-like domain superfamily

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All nucleic 28

cDNA 27

Primer pair 1

Microarray probesets 2

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MGD-MRK-13587, MGD-MRK-19440

Summaries

All 57

Developmental Gene Expression 2

Diseases 1

Gene Ontology 8

Phenotypes 28
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Endou:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136139	Chr15:97629515-97629524 (-)	-300 bp
Tssr136138	Chr15:97629413-97629427 (-)	-200 bp
Tssr136137	Chr15:97629394-97629405 (-)	-180 bp
Tssr136136	Chr15:97629338-97629356 (-)	-127 bp
Tssr136135	Chr15:97629291-97629316 (-)	-84 bp
Tssr136134	Chr15:97629262-97629274 (-)	-48 bp
Tssr136133	Chr15:97629208-97629227 (-)	2 bp
Tssr136132	Chr15:97629176-97629188 (-)	38 bp
Tssr136131	Chr15:97629095-97629107 (-)	119 bp
Tssr136130	Chr15:97629082-97629094 (-)	132 bp
Tssr136129	Chr15:97629040-97629049 (-)	175 bp
Tssr136128	Chr15:97628590-97628610 (-)	620 bp
Tssr136127	Chr15:97618992-97619051 (-)	10,198 bp
Tssr136126	Chr15:97618984-97618991 (-)	10,232 bp
Tssr136125	Chr15:97618324-97618329 (-)	10,893 bp
Tssr136124	Chr15:97617613-97617624 (-)	11,601 bp
Tssr136123	Chr15:97617561-97617574 (-)	11,652 bp
Tssr136122	Chr15:97617468-97617500 (-)	11,736 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24