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Prkar2b Gene Detail
Summary
  • Symbol
    Prkar2b
  • Name
    protein kinase, cAMP dependent regulatory, type II beta
  • Synonyms
    Pkarb2, PKARIIbeta, RII(beta)
  • Feature Type
    protein coding gene
  • IDs
    MGI:97760
    NCBI Gene: 19088
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:32008475-32111295 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 13.74 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3123 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97760
 protein coding gene Chr12:32008468-32111639 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019668
 protein coding gene Chr12:29944097-30041490 (-)
A/J MGP_AJ_G0019635
 protein coding gene Chr12:29087982-29184660 (-)
AKR/J MGP_AKRJ_G0019606
 protein coding gene Chr12:30012562-30113331 (-)
BALB/cJ MGP_BALBcJ_G0019612
 protein coding gene Chr12:29311490-29407066 (-)
C3H/HeJ MGP_C3HHeJ_G0019416
 protein coding gene Chr12:29887901-29987866 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020059
 protein coding gene Chr12:30874120-30979390 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017684
 protein coding gene Chr12:28378743-28479506 (-)
CAST/EiJ MGP_CASTEiJ_G0018971
 protein coding gene Chr12:24890774-24993522 (-)
CBA/J MGP_CBAJ_G0019388
 protein coding gene Chr12:31868658-31973782 (-)
DBA/2J MGP_DBA2J_G0019501
 protein coding gene Chr12:28911782-29013013 (-)
FVB/NJ MGP_FVBNJ_G0019492
 protein coding gene Chr12:28706584-28803802 (-)
LP/J MGP_LPJ_G0019571
 protein coding gene Chr12:30035735-30137092 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019527
 protein coding gene Chr12:31512356-31618773 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020099
 protein coding gene Chr12:29543705-29642864 (-)
PWK/PhJ MGP_PWKPhJ_G0018738
 protein coding gene Chr12:23655098-23762235 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018526
 protein coding gene Chr12:24129512-24232778 (-)
WSB/EiJ MGP_WSBEiJ_G0019021
 protein coding gene Chr12:29777576-29877425 (-)



Homology
more
  • Human Ortholog
    PRKAR2B, protein kinase cAMP-dependent type II regulatory subunit beta
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKAR2B, protein kinase cAMP-dependent type II regulatory subunit beta
  • Synonyms
    PRKAR2, RII-BETA
  • Links
    NCBI Gene ID: 5577
    neXtProt AC: NX_P31323
    UniProt: P31323

  • Chr Location
    7q22.3; chr7:107044705-107161811 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 3 alleles in 10 genetic backgrounds
    11 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygou null mice are lean, weigh less than controls, and have reduced white fat pad size. Mice are resistant to both diet-induced obesity and to diet-induced insulin resistance. Mice show impaired coordination and increased sensitivity to chronic amphetamine exposure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    970
  • Tissues
    83
  • cDNA Data
    88
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002997 Ensembl Gene Model | MGI Sequence Detail 102821 C57BL/6J ±  kb
    transcript ENSMUST00000036497 Ensembl | MGI Sequence Detail 3378 Not Applicable  
    polypeptide ENSMUSP00000039797 Ensembl | MGI Sequence Detail 416 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013231 cAMP-dependent protein kinase type II-beta regulatory subunit
      (term hierarchy)
    • PDB
      3TNP, 3TNQ, 4WBB, 4X6Q
    • EC
      2.7.1.37
    • InterPro Domains
      IPR050503 cAMP-dependent kinase regulatory chain
      IPR012198 cAMP-dependent protein kinase regulatory subunit
      IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
      IPR018488 Cyclic nucleotide-binding, conserved site
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding domain superfamily
      IPR014710 RmlC-like jelly roll fold
    • GlyGen
      P31324 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 92
      Genomic 2
      cDNA 90

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13326, MGD-MRK-13611, MGI:2144832, MGI:2145000
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 14
      Gene Ontology 17
      Phenotypes 28
    • Earliest
      J:280416 Cadd G, et al., Distinct patterns of cAMP-dependent protein kinase gene expression in mouse brain. Neuron. 1989 Jul;3(1):71-9
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory