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Prox1 Gene Detail
Summary
  • Symbol
    Prox1
  • Name
    prospero homeobox 1
  • Synonyms
    A230003G05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:97772
    NCBI Gene: 19130
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:189850232-189902911 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 95.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1048 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97772
 protein coding gene Chr1:189850232-189903024 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016931
 protein coding gene Chr1:197075866-197129433 (-)
A/J MGP_AJ_G0016910
 protein coding gene Chr1:189003364-189056700 (-)
AKR/J MGP_AKRJ_G0016875
 protein coding gene Chr1:194583195-194636385 (-)
BALB/cJ MGP_BALBcJ_G0016868
 protein coding gene Chr1:189678274-189731303 (-)
C3H/HeJ MGP_C3HHeJ_G0016692
 protein coding gene Chr1:195452905-195506049 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017331
 protein coding gene Chr1:203361239-203415584 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015038
 protein coding gene Chr1:179919308-179972717 (-)
CAST/EiJ MGP_CASTEiJ_G0016275
 protein coding gene Chr1:195017939-195071891 (-)
CBA/J MGP_CBAJ_G0016666
 protein coding gene Chr1:210949139-211002105 (-)
DBA/2J MGP_DBA2J_G0016772
 protein coding gene Chr1:187742159-187794715 (-)
FVB/NJ MGP_FVBNJ_G0016768
 protein coding gene Chr1:185856214-185909657 (-)
LP/J MGP_LPJ_G0016847
 protein coding gene Chr1:198257656-198311361 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016800
 protein coding gene Chr1:217639166-217694941 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017368
 protein coding gene Chr1:194492641-194546565 (-)
PWK/PhJ MGP_PWKPhJ_G0016062
 protein coding gene Chr1:187007957-187061079 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015838
 protein coding gene Chr1:193452186-193513781 (-)
WSB/EiJ MGP_WSBEiJ_G0016337
 protein coding gene Chr1:194698800-194753048 (-)



Homology
more
  • Human Ortholog
    PROX1, prospero homeobox 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PROX1, prospero homeobox 1
  • Links
    NCBI Gene ID: 5629
    neXtProt AC: NX_Q92786
    UniProt: Q92786

  • Chr Location
    1q32.3; chr1:213983151-214041510 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Prox1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    61 phenotypes from 6 alleles in 11 genetic backgrounds
    2 phenotypes from multigenic genotypes
    133 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality with impaired development of the lens, lymphatic system, liver and pancreas. Heterozygous mutation results in early postnatal lethality with varying penetrance on different genetic backgrounds, obesity and lymphatic vessel abnormalities
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    98
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2455
  • Tissues
    536
  • cDNA Data
    22
  • Literature Summary
    574
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000010175 Ensembl Gene Model | MGI Sequence Detail 52680 C57BL/6J ±  kb
    transcript ENSMUST00000010319 Ensembl | MGI Sequence Detail 3285 Not Applicable  
    polypeptide ENSMUSP00000010319 Ensembl | MGI Sequence Detail 737 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 1
      cDNA 23
      Primer pair 15
      Other 11

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13626, MGI:2443651
    References
    more
    • Summaries
      All 708
      Developmental Gene Expression 574
      Diseases 2
      Gene Ontology 21
      Phenotypes 133
    • Earliest
      J:16397 Oliver G, et al., Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech Dev. 1993 Nov;44(1):3-16
    • Latest
      J:354217 Ohyama K, et al., Differentiation stage-specific expression of transcriptional regulators for epithelial mesenchymal transition in dentate granule progenitors. Front Neurosci. 2024;18:1425849
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory