Pscr1 QTL Detail

Summary

• Symbol
  Pscr1
• Name
  corneal resistance to P. aeruginosa 1
• Synonyms
  Pscr-1

• Feature Type
  QTL
• IDs
  MGI:97784
  NCBI Gene: 107756

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 5, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype from multigenic genotypes
  1 phenotype reference
  

• All Mutations and Alleles
  3
• QTL
  3
• Find Mice (IMSR)
  0 strains or lines available

Mice resistant to corneal infection by P. aeruginosa have local infections that heal in 3-4 weeks. Infected susceptible mice show necrosis, eye shrinkage and blindness in 12-14 days. Dominant alleles at 2 genes are required for resistance. C57BL/6 has the dominant allele at Pscr1; BALB/c at Pscr2.

Sequences &
Gene Models

• NCBI Gene
  107756

Other
Accession IDs

MGD-MRK-13646, MGD-MRK-13648

References

• Summaries
  All 5

  Phenotypes 1
• Earliest
  J:6633 Berk RS, et al., Genetic studies of the murine corneal response to Pseudomonas aeruginosa. Infect Immun. 1981 Oct;34(1):1-5
• Latest
  J:8914 Berk RS, et al., Genetic studies on resistant and susceptibility genes controlling the mouse cornea to infection with Pseudomonas aeruginosa. Antibiot Chemother. 1987;39:83-91