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Ptger2 Gene Detail
Summary
  • Symbol
    Ptger2
  • Name
    prostaglandin E receptor 2 (subtype EP2)
  • Synonyms
    EP2, EP2 receptor, Ptgerep2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97794
    NCBI Gene: 19217
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:45225652-45241277 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 22.68 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    527 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97794
 protein coding gene Chr14:45225568-45241277 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021203
 protein coding gene Chr14:38592926-38615369 (+)
A/J MGP_AJ_G0021149
 protein coding gene Chr14:37435750-37451408 (+)
AKR/J MGP_AKRJ_G0021127
 protein coding gene Chr14:38935579-38955267 (+)
BALB/cJ MGP_BALBcJ_G0021153
 protein coding gene Chr14:37493869-37512082 (+)
C3H/HeJ MGP_C3HHeJ_G0020936
 protein coding gene Chr14:38732445-38749696 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021587
 protein coding gene Chr14:40268718-40285477 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019146
 protein coding gene Chr14:36889066-36904671 (+)
CAST/EiJ MGP_CASTEiJ_G0020461
 protein coding gene Chr14:35840656-35864540 (+)
CBA/J MGP_CBAJ_G0020902
 protein coding gene Chr14:41544145-41574365 (+)
DBA/2J MGP_DBA2J_G0021025
 protein coding gene Chr14:37375613-37393966 (+)
FVB/NJ MGP_FVBNJ_G0021009
 protein coding gene Chr14:37133510-37150425 (+)
LP/J MGP_LPJ_G0021095
 protein coding gene Chr14:38899161-38913840 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021035
 protein coding gene Chr14:40950304-40967786 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021620
 protein coding gene Chr14:38475368-38492304 (+)
PWK/PhJ MGP_PWKPhJ_G0020210
 protein coding gene Chr14:34238254-34255011 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020032
 protein coding gene Chr14:34601890-34618382 (+)
WSB/EiJ MGP_WSBEiJ_G0020517
 protein coding gene Chr14:38569716-38588502 (+)



Homology
more
  • Human Ortholog
    PTGER2, prostaglandin E receptor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTGER2, prostaglandin E receptor 2
  • Synonyms
    EP2
  • Links
    NCBI Gene ID: 5732
    neXtProt AC: NX_P43116
    UniProt: P43116

  • Chr Location
    14q22.1; chr14:52314305-52328598 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PTGER2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 6 alleles in 12 genetic backgrounds
    8 phenotypes from multigenic genotypes
    137 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for one targeted null mutation exhibit increased blood pressure when fed a high-salt diet. Female mutants for 2 null alleles have small litters due to impaired ovulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    63
  • cDNA Data
    17
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037759 Ensembl Gene Model | MGI Sequence Detail 15626 C57BL/6J ±  kb
    transcript ENSMUST00000046891 Ensembl | MGI Sequence Detail 3684 Not Applicable  
    polypeptide ENSMUSP00000038483 Ensembl | MGI Sequence Detail 362 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 18
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13661
    References
    more
    • Summaries
      All 201
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 137
    • Earliest
      J:25578 Fuller JL, et al., Effects of retinal degeneration and brain size upon spatial reversal learning in mice. Percept Mot Skills. 1973 Jun;36(3):947-50
    • Latest
      J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory