early conceptus |
embryo ectoderm |
embryo endoderm |
embryo mesoderm |
embryo mesenchyme |
extraembryonic component |
alimentary system |
auditory system |
branchial arches |
cardiovascular system |
connective tissue |
endocrine system |
exocrine system |
hemolymphoid system |
integumental system |
limbs |
liver and biliary system |
musculoskeletal system |
nervous system |
olfactory system |
reproductive system |
respiratory system |
urinary system |
visual system |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Transcription Start Site | Location | Distance from Gene 5'-end |
| Tssr17503 | Chr2:36120498-36120503 (+) | 63 bp |
| Tssr17504 | Chr2:36120504-36120557 (+) | 93 bp |
| Tssr17505 | Chr2:36120644-36120719 (+) | 244 bp |
| Tssr17506 | Chr2:36127520-36127522 (+) | 7,083 bp |
| Tssr17507 | Chr2:36127693-36127715 (+) | 7,266 bp |
| Tssr17508 | Chr2:36127743-36127759 (+) | 7,313 bp |
| Tssr17509 | Chr2:36127961-36127997 (+) | 7,541 bp |
| Tssr17510 | Chr2:36129600-36129603 (+) | 9,164 bp |
| Tssr17511 | Chr2:36131925-36131963 (+) | 11,506 bp |
| Tssr17512 | Chr2:36132798-36132801 (+) | 12,362 bp |
| Tssr17513 | Chr2:36139667-36139676 (+) | 19,234 bp |
| Tssr17514 | Chr2:36139707-36139729 (+) | 19,280 bp |
| Tssr17515 | Chr2:36141723-36141739 (+) | 21,293 bp |
| Tssr17516 | Chr2:36141752-36141763 (+) | 21,320 bp |
| QTL | Genetic Location* | Genome Location (GRCm39) | Reference | QTL Note |
| Abhr1 | Chr2, syntenic | J:122917 | The present study fine maps two previously identified airway hyper-responsiveness QTLs on mouse Chromosome 2 named Abhr1 (10 cM) and Abhr2 (30 cM). Thirty-seven polymorphic chromosome 2 markers were genotyped in 450 (C3H/HeJ x A/J)F1 x A/J backcross animals. Mrc1 at 5 cM was identified as a potential candidate gene for Abhr1. Ptgs1 at 29 cM was identified as a potential candidate gene for Abhr2. Sequence analysis of Mrc1 and Ptgs1 sequences did not detect polymorphism between A/J and C3H/HeJ. Gene expression analysis of Mrc1 and Ptgs1 lung mRNA following induction of allergic asthma in A/J and C3H/HeJ animals was performed. Ptgs1 was found to be downregulated in both inbred strains 72 hours after allergic asthma induction; however a strain-specific expression difference was not detected. | |
| Abhr2 | Chr2, 22.83 cM | J:122917 | The present study fine maps two previously identified airway hyper-responsiveness QTLs on mouse Chromosome 2 named Abhr1 (10 cM) and Abhr2 (30 cM). Thirty-seven polymorphic chromosome 2 markers were genotyped in 450 (C3H/HeJ x A/J)F1 x A/J backcross animals. Mrc1 at 5 cM was identified as a potential candidate gene for Abhr1. Ptgs1 at 29 cM was identified as a potential candidate gene for Abhr2. Sequence analysis of Mrc1 and Ptgs1 sequences did not detect polymorphism between A/J and C3H/HeJ. Gene expression analysis of Mrc1 and Ptgs1 lung mRNA following induction of allergic asthma in A/J and C3H/HeJ animals was performed. Ptgs1 was found to be downregulated in both inbred strains 72 hours after allergic asthma induction; however a strain-specific expression difference was not detected. |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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