Ptpn1 MGI Mouse Gene Detail - MGI:97805 - protein tyrosine phosphatase, non-receptor type 1

Symbol

Ptpn1
Name

protein tyrosine phosphatase, non-receptor type 1
Synonyms

PTP-1B, PTP1B

Feature Type

protein coding gene
IDs

MGI:97805
NCBI Gene: 19246
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:167773977-167821305 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 87.99 cM, cytoband H3
Mapping Data

3 experiments

SNPs within 2kb

881 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97805	protein coding gene	Chr2:167772670-167821305 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026919	protein coding gene	Chr2:173724873-173775604 (+)
A/J	MGP_AJ_G0026886	protein coding gene	Chr2:166556748-166604483 (+)
AKR/J	MGP_AKRJ_G0026857	protein coding gene	Chr2:171520660-171567871 (+)
BALB/cJ	MGP_BALBcJ_G0026895	protein coding gene	Chr2:166910206-166957180 (+)
C3H/HeJ	MGP_C3HHeJ_G0026637	protein coding gene	Chr2:171894849-171945174 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027342	protein coding gene	Chr2:178790376-178837502 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024713	protein coding gene	Chr2:159857669-159905458 (+)
CAST/EiJ	MGP_CASTEiJ_G0026095	protein coding gene	Chr2:172363852-172411038 (+)
CBA/J	MGP_CBAJ_G0026614	protein coding gene	Chr2:185370315-185419463 (+)
DBA/2J	MGP_DBA2J_G0026752	protein coding gene	Chr2:165657490-165704458 (+)
FVB/NJ	MGP_FVBNJ_G0026718	protein coding gene	Chr2:164211224-164258981 (+)
LP/J	MGP_LPJ_G0026853	protein coding gene	Chr2:173734685-173783486 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026737	protein coding gene	Chr2:188696076-188743768 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027399	protein coding gene	Chr2:171456077-171503381 (+)
PWK/PhJ	MGP_PWKPhJ_G0025832	protein coding gene	Chr2:165344104-165392289 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025633	protein coding gene	Chr2:170405143-170455073 (+)
WSB/EiJ	MGP_WSBEiJ_G0026168	protein coding gene	Chr2:172367548-172416050 (+)

Human Ortholog

PTPN1, protein tyrosine phosphatase non-receptor type 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPN1, protein tyrosine phosphatase non-receptor type 1
Synonyms

PTP1B
Links

HGNC:9642

NCBI Gene ID: 5770

neXtProt AC: NX_P18031

UniProt: P18031
Chr Location

20q13.13; chr20:50510321-50585241 (+) GRCh38

MGI Vertebrate Homology

Ptpn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PTPN1
Protein SuperFamily

Tyr-Ptase_nr1
Gene Tree

Ptpn1

Diseases

3 with human PTPN1 associations

				Human Disease	Mouse Models
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				essential hypertension IDs essential hypertension DOID:10825 ICD10CM:I10 ICD9CM:401 ICD9CM:401.9 MESH:D000075222 NCI:C3478 OMIM:145500 OMIM:603918 OMIM:604329 OMIM:607329 OMIM:608742 OMIM:610261 OMIM:610262 OMIM:610948 OMIM:611014 ORDO:243761 UMLS_CUI:C0085580
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

35 phenotypes from 5 alleles in 7 genetic backgrounds
19 phenotypes from multigenic genotypes
133 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Endonuclease-mediated

3
Gene trapped

12
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit greatly reduced adiposity due to reduced fat cell mass, increased basal metabolic rate, mild hypoglycemia and hypoinsulinemia, increased insulin sensitivity, and enhanced sensitivity to leptin.

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All GO Annotations

116
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

6
cDNA Data

129
Literature Summary

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptpn1

ZFIN ptpn1

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All Sequences

86
RefSeq

8
UniProt

5
CCDS

CCDS17107.1

Ensembl

ENSMUSG00000027540 (Evidence)
NCBI Gene

19246

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027540	Ensembl Gene Model \| MGI Sequence Detail	47329	C57BL/6J	± kb
transcript	ENSMUST00000029053	Ensembl \| MGI Sequence Detail	4213	Not Applicable
polypeptide	ENSMUSP00000029053	Ensembl \| MGI Sequence Detail	432	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013448 tyrosine-protein phosphatase non-receptor type 1

(term hierarchy)
EC

3.1.3.48
InterPro Domains

IPR051985 Non-receptor type tyrosine-specific phosphatase

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain
GlyGen

P35821 1 site, 1 O-linked glycan (1 site)

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All nucleic 131

Genomic 1

cDNA 129

Primer pair 1

Microarray probesets 4

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MGD-MRK-13674

Summaries

All 221

Developmental Gene Expression 7

Gene Ontology 14

Phenotypes 133
Earliest

J:29004 Yi T, et al., Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood. 1991 Nov 1;78(9):2222-8
Latest

J:348630 Ge X, et al., Overexpression of forebrain PTP1B leads to synaptic and cognitive impairments in obesity. Brain Behav Immun. 2024 Mar;117:456-470

TSS for Ptpn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21855	Chr2:167773943-167773984 (+)	-13 bp
Tssr21856	Chr2:167774256-167774299 (+)	301 bp
Tssr21857	Chr2:167774303-167774320 (+)	335 bp
Tssr21858	Chr2:167778394-167778403 (+)	4,422 bp
Tssr21859	Chr2:167782718-167782722 (+)	8,743 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24