Ptprb MGI Mouse Gene Detail - MGI:97809 - protein tyrosine phosphatase receptor type B

Symbol

Ptprb
Name

protein tyrosine phosphatase receptor type B
Synonyms

3230402H02Rik, VE-PTP

Feature Type

protein coding gene
IDs

MGI:97809
NCBI Gene: 19263
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr10:116111428-116225440 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 64.68 cM, cytoband D2
Mapping Data

2 experiments

SNPs within 2kb

3620 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97809	protein coding gene	Chr10:116111407-116225443 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017744	protein coding gene	Chr10:119062780-119158258 (+)
A/J	MGP_AJ_G0017720	protein coding gene	Chr10:114488765-114578770 (+)
AKR/J	MGP_AKRJ_G0017682	protein coding gene	Chr10:117787275-117895841 (+)
BALB/cJ	MGP_BALBcJ_G0017683	protein coding gene	Chr10:114887949-114980411 (+)
C3H/HeJ	MGP_C3HHeJ_G0017508	protein coding gene	Chr10:118031441-118125112 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018140	protein coding gene	Chr10:123199441-123301595 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015820	protein coding gene	Chr10:109094240-109179492 (+)
CAST/EiJ	MGP_CASTEiJ_G0017070	protein coding gene	Chr10:118307435-118402088 (+)
CBA/J	MGP_CBAJ_G0017477	protein coding gene	Chr10:128015882-128120446 (+)
DBA/2J	MGP_DBA2J_G0017582	protein coding gene	Chr10:113631990-113720081 (+)
FVB/NJ	MGP_FVBNJ_G0017577	protein coding gene	Chr10:112588106-112675937 (+)
LP/J	MGP_LPJ_G0017657	protein coding gene	Chr10:119652291-119745870 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017606	protein coding gene	Chr10:130929949-131026479 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018178	protein coding gene	Chr10:117868185-117962701 (+)
PWK/PhJ	MGP_PWKPhJ_G0016852	protein coding gene	Chr10:113711608-113802886 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016642	protein coding gene	Chr10:116673368-116772153 (+)
WSB/EiJ	MGP_WSBEiJ_G0017130	protein coding gene	Chr10:118044580-118145338 (+)

Human Ortholog

PTPRB, protein tyrosine phosphatase receptor type B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPRB, protein tyrosine phosphatase receptor type B
Synonyms

HPTPB, HPTP-BETA, PTPB, R-PTP-BETA, VEPTP
Links

HGNC:9665

NCBI Gene ID: 5787

neXtProt AC: NX_P23467

UniProt: P23467
Chr Location

12q15; chr12:70515870-70637440 (-) GRCh38

MGI Vertebrate Homology

Ptprb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PTPRB
Gene Tree

Ptprb

Diseases

7 with human PTPRB associations

				Human Disease	Mouse Models
				angiosarcoma IDs angiosarcoma DOID:0001816 DOID:267 DOID:4508 MESH:D006394 NCI:C3088 NCI:C9275 UMLS_CUI:C0018923 UMLS_CUI:C0854893
				brain glioma IDs brain glioma DOID:0060108
				breast angiosarcoma IDs breast angiosarcoma DOID:4511 MESH:C536368 NCI:C5184 UMLS_CUI:C1332614
				colorectal carcinoma IDs colorectal carcinoma DOID:0080199 EFO:1001951 MESH:D015179 NCI:C2955 UMLS_CUI:C0009402
				glioblastoma IDs glioblastoma DOID:3068 DOID:3075 DOID:3080 MESH:D005909 NCI:C129295 NCI:C39750 NCI:C9094 UMLS_CUI:C0017636 UMLS_CUI:C0278878 UMLS_CUI:C1514422
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				sarcoma IDs sarcoma DOID:1115 DOID:3936 ICD10CM:C49 ICD9CM:171 ICD9CM:171.9 UMLS_CUI:C0153519

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

21 phenotypes from 3 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
4 images
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

7
Genomic Mutations

1 involving Ptprb
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

99 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality at E10, impaired vascular maintenace and remodeling, heart defects and abnormal yolk sac vasculature.

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All GO Annotations

18
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

823
Tissues

50
cDNA Data

13
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptprb

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All Sequences

62
RefSeq

16
UniProt

7
CCDS

CCDS36063.1

Ensembl

ENSMUSG00000020154 (Evidence)
NCBI Gene

19263

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020154	Ensembl Gene Model \| MGI Sequence Detail	114013	C57BL/6J	± kb
transcript	ENSMUST00000218553	Ensembl \| MGI Sequence Detail	7016	Not Applicable
polypeptide	ENSMUSP00000151821	Ensembl \| MGI Sequence Detail	2285	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000013465 receptor-type tyrosine-protein phosphatase beta

(term hierarchy)
EC

3.1.3.48
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR041201 PTPRJ, transmembrane domain

IPR050713 Receptor-type Tyrosine-protein Phosphatases/Ushers

IPR000772 Ricin B, lectin domain

IPR035992 Ricin B-like lectins

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain
GlyGen

B2RU80 34 sites, 10 N-linked glycans (16 sites)

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All nucleic 20

cDNA 16

Primer pair 4

Microarray probesets 5

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MGD-MRK-13678, MGI:1924822

Summaries

All 67

Developmental Gene Expression 10

Gene Ontology 13

Phenotypes 22
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:325730 Ahuja N, et al., Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95

TSS for Ptprb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95853	Chr10:116111396-116111409 (+)	-25 bp
Tssr95854	Chr10:116111441-116111481 (+)	33 bp
Tssr95855	Chr10:116111486-116111495 (+)	63 bp
Tssr95856	Chr10:116125284-116125303 (+)	13,866 bp
Tssr95857	Chr10:116137322-116137333 (+)	25,900 bp
Tssr95858	Chr10:116137360-116137380 (+)	25,942 bp
Tssr95859	Chr10:116137394-116137409 (+)	25,974 bp
Tssr95860	Chr10:116145926-116145930 (+)	34,500 bp
Tssr95861	Chr10:116150960-116150981 (+)	39,543 bp
Tssr95862	Chr10:116161134-116161138 (+)	49,708 bp
Tssr95863	Chr10:116182785-116182794 (+)	71,362 bp
Tssr95864	Chr10:116183291-116183294 (+)	71,865 bp
Tssr95865	Chr10:116201264-116201277 (+)	89,843 bp
Tssr95866	Chr10:116208766-116208770 (+)	97,340 bp
Tssr95867	Chr10:116213536-116213537 (+)	102,109 bp
Tssr95868	Chr10:116223374-116223380 (+)	111,949 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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