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Ptprz1 Gene Detail
Summary
  • Symbol
    Ptprz1
  • Name
    protein tyrosine phosphatase receptor type Z, polypeptide 1
  • Synonyms
    DSD-1-PG, phosphacan, PTPbeta, Ptprz, Ptpz, PTPzeta, Rptpbeta, RPTPz
  • Feature Type
    protein coding gene
  • IDs
    MGI:97816
    NCBI Gene: 19283
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:22875501-23052915 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 9.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    5605 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97816
 protein coding gene Chr6:22875302-23052915 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030485
 protein coding gene Chr6:20383125-20566861 (+)
A/J MGP_AJ_G0030458
 protein coding gene Chr6:19546765-19728319 (+)
AKR/J MGP_AKRJ_G0030385
 protein coding gene Chr6:20182129-20374222 (+)
BALB/cJ MGP_BALBcJ_G0030468
 protein coding gene Chr6:19639352-19818478 (+)
C3H/HeJ MGP_C3HHeJ_G0030181
 protein coding gene Chr6:20148584-20329221 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030922
 protein coding gene Chr6:21030632-21220884 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028133
 protein coding gene Chr6:18124183-18301018 (+)
CAST/EiJ MGP_CASTEiJ_G0029583
 protein coding gene Chr6:20051230-20248132 (+)
CBA/J MGP_CBAJ_G0030159
 protein coding gene Chr6:21742526-21944793 (+)
DBA/2J MGP_DBA2J_G0030303
 protein coding gene Chr6:19469350-19648994 (+)
FVB/NJ MGP_FVBNJ_G0030257
 protein coding gene Chr6:19252365-19433928 (+)
LP/J MGP_LPJ_G0030390
 protein coding gene Chr6:20519574-20708084 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030293
 protein coding gene Chr6:23582172-23779308 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030952
 protein coding gene Chr6:20143254-20330358 (+)
PWK/PhJ MGP_PWKPhJ_G0029297
 protein coding gene Chr6:19084595-19270441 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029133
 protein coding gene Chr6:19863406-20045118 (+)
WSB/EiJ MGP_WSBEiJ_G0029659
 protein coding gene Chr6:20044011-20231199 (+)



Homology
more
  • Human Ortholog
    PTPRZ1, protein tyrosine phosphatase receptor type Z1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPRZ1, protein tyrosine phosphatase receptor type Z1
  • Synonyms
    HPTPZ, HPTPzeta, phosphacan, PTP18, PTPRZ, PTPZ, PTP-ZETA, RPTPB, RPTPbeta, R-PTP-zeta-2
  • Links
    NCBI Gene ID: 5803
    neXtProt AC: NX_P23471
    UniProt: P23471

  • Chr Location
    7q31.32; chr7:121873089-122062036 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 7 genetic backgrounds
    3 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted null mutations demonstrate an impaired ability to recover from inflamatory lesions of the CNS or gastric mucosa. Mice homozygous for a knock-out allele exhibit increased tactile and thermal nociception thresholds.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1205
  • Tissues
    181
  • cDNA Data
    193
  • Literature Summary
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068748 Ensembl Gene Model | MGI Sequence Detail 177415 C57BL/6J ±  kb
    transcript ENSMUST00000090568 Ensembl | MGI Sequence Detail 8068 Not Applicable  
    polypeptide ENSMUSP00000088056 Ensembl | MGI Sequence Detail 2312 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      23 Sequences
    • Protein Ontology
      PR:000013482 receptor-type tyrosine-protein phosphatase zeta
      (term hierarchy)
    • EC
      3.1.3.48
    • InterPro Domains
      IPR001148 Alpha carbonic anhydrase domain
      IPR036398 Alpha carbonic anhydrase domain superfamily
      IPR023561 Carbonic anhydrase, alpha-class
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR013783 Immunoglobulin-like fold
      IPR050348 Protein-Tyrosine Phosphatase
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR029021 Protein-tyrosine phosphatase-like
      IPR041887 Receptor-type tyrosine-protein phosphatase, carbonic anhydrase domain
      IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
      IPR000387 Tyrosine-specific protein phosphatases domain
    • GlyGen
      B9EKR1 17 sites, 30 N-linked glycans (13 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 210
      Genomic 2
      cDNA 194
      Primer pair 12
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-13685, MGI:2141501
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 41
      Gene Ontology 17
      Phenotypes 36
    • Earliest
      J:16798 Krueger NX, et al., A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7417-21
    • Latest
      J:351385 Kaneko N, et al., ADAMTS2 promotes radial migration by activating TGF-beta signaling in the developing neocortex. EMBO Rep. 2024 Jul;25(7):3090-3115
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory