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Nectin2 Gene Detail
Summary
  • Symbol
    Nectin2
  • Name
    nectin cell adhesion molecule 2
  • Synonyms
    Cd112, MPH, nectin-2, Pvrl2, Pvs
  • Feature Type
    protein coding gene
  • IDs
    MGI:97822
    NCBI Gene: 19294
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19450569-19483498 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.94 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    955 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97822
 protein coding gene Chr7:19450569-19484408 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031794
 protein coding gene Chr7:17758786-17799672 (-)
A/J MGP_AJ_G0031770
 protein coding gene Chr7:17365967-17399783 (-)
AKR/J MGP_AKRJ_G0031696
 protein coding gene Chr7:17850673-17887753 (-)
BALB/cJ MGP_BALBcJ_G0031775
 protein coding gene Chr7:17572491-17607113 (-)
C3H/HeJ MGP_C3HHeJ_G0031497
 protein coding gene Chr7:18113488-18147589 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032241
 protein coding gene Chr7:18636191-18677182 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029307
 protein coding gene Chr7:19014987-19047983 (-)
CAST/EiJ MGP_CASTEiJ_G0030840
 protein coding gene Chr7:14559855-14608858 (-)
CBA/J MGP_CBAJ_G0031459
 protein coding gene Chr7:19308594-19352704 (-)
DBA/2J MGP_DBA2J_G0031614
 protein coding gene Chr7:17321261-17354116 (-)
FVB/NJ MGP_FVBNJ_G0031566
 protein coding gene Chr7:17188280-17226122 (-)
LP/J MGP_LPJ_G0031697
 protein coding gene Chr7:18071097-18107977 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031602
 protein coding gene Chr7:19129649-19168399 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032269
 protein coding gene Chr7:17464182-17500646 (-)
PWK/PhJ MGP_PWKPhJ_G0030564
 protein coding gene Chr7:14420759-14455040 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030391
 protein coding gene Chr7:12169806-12206135 (-)
WSB/EiJ MGP_WSBEiJ_G0030940
 protein coding gene Chr7:17679908-17719230 (-)



Homology
more
  • Human Ortholog
    NECTIN2, nectin cell adhesion molecule 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NECTIN2, nectin cell adhesion molecule 2
  • Synonyms
    CD112, HVEB, PRR2, PVRL2, PVRR2
  • Links
    NCBI Gene ID: 5819
    neXtProt AC: NX_Q92692
    UniProt: Q92692

  • Chr Location
    19q13.32; chr19:44846175-44889223 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human NECTIN2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted null mutations exhibit male sterility associated with sperm head and midpiece malformation, impaired zona binding, and lack of oocyte penetration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    38
  • cDNA Data
    93
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19294 NCBI Gene Model | MGI Sequence Detail 32930 C57BL/6J ±  kb
    transcript NM_008990 RefSeq | MGI Sequence Detail 2735 ZRU/MplStud  
    polypeptide P32507 UniProt | EBI | MGI Sequence Detail 530 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      Genomic 4
      cDNA 95
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13693, MGD-MRK-13694, MGI:2141913, MGI:2142081
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 18
      Gene Ontology 14
      Phenotypes 22
    • Earliest
      J:48199 Mendelsohn C, et al., Transformation of a human poliovirus receptor gene into mouse cells. Proc Natl Acad Sci U S A. 1986 Oct;83(20):7845-9
    • Latest
      J:325483 Russo E, et al., CD112 Regulates Angiogenesis and T Cell Entry into the Spleen. Cells. 2021 Jan 15;10(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory