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Pvt1 Gene Detail
Summary
  • Symbol
    Pvt1
  • Name
    Pvt1 oncogene
  • Synonyms
    Ayu21-84Imeg, Gt(Ayu21)84Imeg, Mis-1, Mlvi-1, Pvt-1
  • Feature Type
    lncRNA gene
  • IDs
    MGI:97824
    NCBI Gene: 19296
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:61909835-62132064 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 26.24 cM, cytoband D2-D3
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6018 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97824
 lncRNA gene Chr15:61909817-62249945 (+)
129S1/SvImJ MGP_129S1SvImJ_G0005602
 lincRNA gene Chr15:61385176-61742125 (+)
A/J MGP_AJ_G0005588
 lincRNA gene Chr15:58978553-59321477 (+)
AKR/J MGP_AKRJ_G0005567
 lincRNA gene Chr15:60628847-60978004 (+)
BALB/cJ MGP_BALBcJ_G0005569
 lincRNA gene Chr15:59171314-59513734 (+)
C3H/HeJ MGP_C3HHeJ_G0005516
 lincRNA gene Chr15:60750691-61106270 (+)
C57BL/6NJ MGP_C57BL6NJ_G0005726
 lincRNA gene Chr15:63695231-64061779 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0005092
 lincRNA gene Chr15:56055554-56396857 (+)
CAST/EiJ MGP_CASTEiJ_G0005459
 lincRNA gene Chr15:61403373-61766756 (+)
CBA/J MGP_CBAJ_G0005506
 lincRNA gene Chr15:65958196-66306371 (+)
DBA/2J MGP_DBA2J_G0005521
 lincRNA gene Chr15:58848154-59190923 (+)
FVB/NJ MGP_FVBNJ_G0005547
 lincRNA gene Chr15:57893875-58238730 (+)
LP/J MGP_LPJ_G0005605
 lincRNA gene Chr15:61269562-61616846 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0005532
 lincRNA gene Chr15:70923919-71297902 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0005726
 lincRNA gene Chr15:61013983-61369735 (+)
PWK/PhJ MGP_PWKPhJ_G0005409
 lincRNA gene Chr15:58914689-59263547 (+)
SPRET/EiJ MGP_SPRETEiJ_G0005327
 lincRNA gene Chr15:60791602-61156448 (+)
WSB/EiJ MGP_WSBEiJ_G0005509
 lincRNA gene Chr15:61037764-61401938 (+)



Homology
more
  • Human Ortholog
    PVT1, Pvt1 oncogene
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PVT1, Pvt1 oncogene
  • Synonyms
    LINC00079, MIR1204HG, NCRNA00079, onco-lncRNA-100, TP53LC09
  • Links
    NCBI Gene ID: 5820

  • Chr Location
    8q24.21; chr8:127794524-128187101 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PVT1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotype references
  • All Mutations and Alleles
    234
  • Chemically induced (other)
    3
  • Endonuclease-mediated
    1
  • Gene trapped
    227
  • Radiation induced
    2
  • Transposon induced
    1
  • Genomic Mutations
    6 involving Pvt1
  • Find Mice (IMSR)
    200 strains or lines available
10-25% of B-cell plasmacytomas have (6;15) translocations that bring Myc into proximity with Igk. The Chr 15 breakpoint occurs at Pvt1, located >72 kb distal to Myc. These tumors have an activated Myc. In addition, some T-cell lymphomas have been shown to have proviral inserts at the Pvt1 locus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    35
  • Literature Summary
    3
Sequences &
Gene Models
less
  • All Sequences
    173
  • RefSeq
    3
  • UniProt
    2
Representative SequencesLengthStrain/SpeciesFlank
genomic 19296 NCBI Gene Model | MGI Sequence Detail 222230 C57BL/6J ±  kb
transcript NR_003368 RefSeq | MGI Sequence Detail 3076 ZRU/MplStud  
polypeptide Q3UMI8 UniProt | EBI | MGI Sequence Detail 76 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
Molecular
Reagents
less
  • All nucleic 63
    Genomic 22
    cDNA 39
    Other 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-12245, MGD-MRK-12267, MGD-MRK-13696, MGD-MRK-13697, MGI:3629704
References
more
  • Summaries
    All 93
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 1
    Phenotypes 35
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345517 Eckberg K, et al., Small hairpin inhibitory RNA delivery in the metanephric organ culture identifies long noncoding RNA Pvt1 as a modulator of cyst growth. Am J Physiol Renal Physiol. 2022 Sep 1;323(3):F335-F348
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory