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Rab3a Gene Detail
Summary
  • Symbol
    Rab3a
  • Name
    RAB3A, member RAS oncogene family
  • Feature Type
    protein coding gene
  • IDs
    MGI:97843
    NCBI Gene: 19339
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:71207328-71211323 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97843
 protein coding gene Chr8:71207258-71211323 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033723
 protein coding gene Chr8:71056795-71059619 (+)
A/J MGP_AJ_G0033706
 protein coding gene Chr8:68160514-68163338 (+)
AKR/J MGP_AKRJ_G0033631
 protein coding gene Chr8:70115442-70119440 (+)
BALB/cJ MGP_BALBcJ_G0033702
 protein coding gene Chr8:68396348-68399172 (+)
C3H/HeJ MGP_C3HHeJ_G0033412
 protein coding gene Chr8:70761226-70764050 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034219
 protein coding gene Chr8:73736213-73739037 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031163
 protein coding gene Chr8:62978242-62981079 (+)
CAST/EiJ MGP_CASTEiJ_G0032737
 protein coding gene Chr8:70234601-70237418 (+)
CBA/J MGP_CBAJ_G0033390
 protein coding gene Chr8:76401281-76404105 (+)
DBA/2J MGP_DBA2J_G0033544
 protein coding gene Chr8:67879277-67882101 (+)
FVB/NJ MGP_FVBNJ_G0033485
 protein coding gene Chr8:67016554-67019378 (+)
LP/J MGP_LPJ_G0033631
 protein coding gene Chr8:71077838-71080662 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033528
 protein coding gene Chr8:79029928-79032752 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034237
 protein coding gene Chr8:70294552-70297376 (+)
PWK/PhJ MGP_PWKPhJ_G0032445
 protein coding gene Chr8:67176645-67179469 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032281
 protein coding gene Chr8:69261052-69264036 (+)
WSB/EiJ MGP_WSBEiJ_G0032852
 protein coding gene Chr8:70661871-70664682 (+)



Homology
more
  • Human Ortholog
    RAB3A, RAB3A, member RAS oncogene family
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB3A, RAB3A, member RAS oncogene family
  • Links
    NCBI Gene ID: 5864
    neXtProt AC: NX_P20336
    UniProt: P20336

  • Chr Location
    19p13.11; chr19:18196784-18204042 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 4 genetic backgrounds
    14 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Rab3a
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    15 strains or lines available
Homozygous null mutants show impaired synaptic transmission, insulin secretion and glucose intolerance. This mutation and another chemically induced allele affect circadian period and sleep patterns. Heterozygotes show milder circadian rhythm anomalies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    96
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    21
  • cDNA Data
    79
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031840 Ensembl Gene Model | MGI Sequence Detail 3996 C57BL/6J ±  kb
transcript ENSMUST00000110093 Ensembl | MGI Sequence Detail 1442 Not Applicable  
polypeptide ENSMUSP00000105720 Ensembl | MGI Sequence Detail 220 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 81
    Genomic 2
    cDNA 79

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-13746
References
more
  • Summaries
    All 117
    Developmental Gene Expression 11
    Gene Ontology 28
    Phenotypes 43
  • Earliest
    J:13259 Baumert M, et al., Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes. Biochem J. 1993 Jul 1;293(Pt 1):157-63
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory