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Rac1 Gene Detail
Summary
  • Symbol
    Rac1
  • Name
    Rac family small GTPase 1
  • Synonyms
    D5Ertd559e
  • Feature Type
    protein coding gene
  • IDs
    MGI:97845
    NCBI Gene: 19353
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:143491236-143513786 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 82.22 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    640 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97845
 protein coding gene Chr5:143489389-143513791 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030333
 protein coding gene Chr5:148836019-148862378 (-)
A/J MGP_AJ_G0030302
 protein coding gene Chr5:142452840-142477400 (-)
AKR/J MGP_AKRJ_G0030234
 protein coding gene Chr5:146911383-146940079 (-)
BALB/cJ MGP_BALBcJ_G0030319
 protein coding gene Chr5:143696245-143721232 (-)
C3H/HeJ MGP_C3HHeJ_G0030030
 protein coding gene Chr5:147727734-147754723 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030764
 protein coding gene Chr5:154276915-154304393 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027982
 protein coding gene Chr5:136221610-136246886 (-)
CAST/EiJ MGP_CASTEiJ_G0029435
 protein coding gene Chr5:147225071-147253790 (-)
CBA/J MGP_CBAJ_G0030000
 protein coding gene Chr5:160636516-160665618 (-)
DBA/2J MGP_DBA2J_G0030150
 protein coding gene Chr5:142215845-142241785 (-)
FVB/NJ MGP_FVBNJ_G0030105
 protein coding gene Chr5:141426661-141451123 (-)
LP/J MGP_LPJ_G0030236
 protein coding gene Chr5:149437204-149465038 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030136
 protein coding gene Chr5:163019792-163045636 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030804
 protein coding gene Chr5:146769258-146794280 (-)
PWK/PhJ MGP_PWKPhJ_G0029150
 protein coding gene Chr5:141303967-141326289 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028986
 protein coding gene Chr5:144504627-144543493 (-)
WSB/EiJ MGP_WSBEiJ_G0029508
 protein coding gene Chr5:147564280-147586210 (-)



Homology
more
  • Human Ortholog
    RAC1, Rac family small GTPase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAC1, Rac family small GTPase 1
  • Synonyms
    MIG5, MRD48, p21-Rac1, Rac-1, TC-25
  • Links
    NCBI Gene ID: 5879
    neXtProt AC: NX_P63000
    UniProt: P63000

  • Chr Location
    7p22.1; chr7:6374527-6403967 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human RAC1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    121 phenotypes from 10 alleles in 15 genetic backgrounds
    16 phenotypes from multigenic genotypes
    247 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit embryonic lethality prior to embryonic day 9.5 with defects in gastrulation. Neutrophil specific knockout mice show defects in inflammatory recruitment and chemotactic responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    204
  • GO References
    68
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1053
  • Tissues
    205
  • cDNA Data
    25
  • Literature Summary
    95
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19353 NCBI Gene Model | MGI Sequence Detail 22551 C57BL/6J ±  kb
    transcript NM_001347530 RefSeq | MGI Sequence Detail 2364 ZRU/MplStud  
    polypeptide P63001 UniProt | EBI | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 1
      cDNA 25
      Primer pair 6
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13748, MGI:1261850, MGI:2141016
    References
    more
    • Summaries
      All 617
      Developmental Gene Expression 95
      Gene Ontology 68
      Phenotypes 247
    • Earliest
      J:724 Moll J, et al., The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments. Oncogene. 1991 May;6(5):863-6
    • Latest
      J:353444 Bessa P, et al., Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring. Nat Commun. 2024 Aug 16;15(1):7059
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory