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Rap1a Gene Detail
Summary
  • Symbol
    Rap1a
  • Name
    RAS-related protein 1a
  • Synonyms
    Krev-1, Rap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97852
    NCBI Gene: 109905
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:105634583-105708652 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.45 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1565 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97852
 protein coding gene Chr3:105634576-105708740 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027720
 protein coding gene Chr3:107102582-107184108 (-)
A/J MGP_AJ_G0027680
 protein coding gene Chr3:103676738-103750113 (-)
AKR/J MGP_AKRJ_G0027645
 protein coding gene Chr3:106249817-106332098 (-)
BALB/cJ MGP_BALBcJ_G0027692
 protein coding gene Chr3:103459698-103536918 (-)
C3H/HeJ MGP_C3HHeJ_G0027422
 protein coding gene Chr3:106588800-106668023 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028136
 protein coding gene Chr3:111103566-111188766 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025476
 protein coding gene Chr3:99755057-99832457 (-)
CAST/EiJ MGP_CASTEiJ_G0026878
 protein coding gene Chr3:105742577-105822274 (-)
CBA/J MGP_CBAJ_G0027397
 protein coding gene Chr3:114844238-114927090 (-)
DBA/2J MGP_DBA2J_G0027539
 protein coding gene Chr3:102916519-102994264 (-)
FVB/NJ MGP_FVBNJ_G0027507
 protein coding gene Chr3:100850479-100916540 (-)
LP/J MGP_LPJ_G0027646
 protein coding gene Chr3:108503528-108583677 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027537
 protein coding gene Chr3:120959883-121053156 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028191
 protein coding gene Chr3:105803185-105882949 (-)
PWK/PhJ MGP_PWKPhJ_G0026604
 protein coding gene Chr3:102696800-102775666 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026425
 protein coding gene Chr3:103829534-103908738 (-)
WSB/EiJ MGP_WSBEiJ_G0026958
 protein coding gene Chr3:106359373-106438283 (-)



Homology
more
  • Human Ortholog
    RAP1A, RAP1A, member of RAS oncogene family
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAP1A, RAP1A, member of RAS oncogene family
  • Synonyms
    C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21
  • Links
    NCBI Gene ID: 5906
    neXtProt AC: NX_P62834
    UniProt: P62834

  • Chr Location
    1p13.2; chr1:111542009-111716691 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    4
  • Gene trapped
    10
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Rap1a
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    25 strains or lines available
Mice homozygous for a null allele exhibit impaired leukocyte migration and decreased angiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    23
  • cDNA Data
    11
  • Literature Summary
    13
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000068798 Ensembl Gene Model | MGI Sequence Detail 74070 C57BL/6J ±  kb
transcript ENSMUST00000090678 Ensembl | MGI Sequence Detail 2407 Not Applicable  
polypeptide ENSMUSP00000088174 Ensembl | MGI Sequence Detail 184 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 2
    cDNA 12
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-11607, MGD-MRK-13761, MGI:2139815
References
more
  • Summaries
    All 144
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 20
    Phenotypes 56
  • Earliest
    J:9524 Kitayama H, et al., A ras-related gene with transformation suppressor activity. Cell. 1989 Jan 13;56(1):77-84
  • Latest
    J:355712 Yamamoto K, et al., Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice. FASEB J. 2023 Dec;37(12):e23310
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory