Rara Gene Detail

Summary

• Symbol
  Rara
• Name
  retinoic acid receptor, alpha
• Synonyms
  RAR alpha 1, RARalpha1

• Feature Type
  protein coding gene
• IDs
  MGI:97856
  NCBI Gene: 19401
• Alliance
  gene page
• Transcription Start Sites
  26 TSS
• Candidate for QTL
  8 QTL

Location &
Maps

• Sequence Map
  Chr11:98818644-98865768 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 62.76 cM, cytoband D-E1
• Mapping Data
  15 experiments

Strain
Comparison

• SNPs within 2kb
  817 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  4

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97856	protein coding gene	Chr11:98818626-98865768 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019078	protein coding gene	Chr11:101555293-101605251 (+)
A/J	MGP_AJ_G0019046	protein coding gene	Chr11:97286736-97337198 (+)
AKR/J	MGP_AKRJ_G0019016	protein coding gene	Chr11:100303343-100352071 (+)
BALB/cJ	MGP_BALBcJ_G0019020	protein coding gene	Chr11:97781487-97829777 (+)
C3H/HeJ	MGP_C3HHeJ_G0018833	protein coding gene	Chr11:100447965-100498718 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019471	protein coding gene	Chr11:104660023-104724829 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017103	protein coding gene	Chr11:94845026-94892235 (+)
CAST/EiJ	MGP_CASTEiJ_G0018387	protein coding gene	Chr11:101433194-101488529 (+)
CBA/J	MGP_CBAJ_G0018804	protein coding gene	Chr11:109032484-109082946 (+)
DBA/2J	MGP_DBA2J_G0018912	protein coding gene	Chr11:96849454-96898328 (+)
FVB/NJ	MGP_FVBNJ_G0018901	protein coding gene	Chr11:96363904-96412196 (+)
LP/J	MGP_LPJ_G0018982	protein coding gene	Chr11:102006266-102057753 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018928	protein coding gene	Chr11:108712325-108766676 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019511	protein coding gene	Chr11:100660831-100707986 (+)
PWK/PhJ	MGP_PWKPhJ_G0018158	protein coding gene	Chr11:97893653-97948560 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017947	protein coding gene	Chr11:100410038-100461376 (+)
WSB/EiJ	MGP_WSBEiJ_G0018436	protein coding gene	Chr11:100618045-100669919 (+)

Homology

• Human Ortholog
  RARA, retinoic acid receptor alpha

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  RARA, retinoic acid receptor alpha
  
• Synonyms
  NR1B1, RAR, RARalpha
• Links
  HGNC:9864

  NCBI Gene ID: 5914

  neXtProt AC: NX_P10276

  UniProt: P10276

  
  
• Chr Location
  17q21.2; chr17:40309180-40357643 (+)  GRCh38

---

• MGI Vertebrate Homology
  Rara stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: RARA
• Gene Tree
  Rara
  

Human Diseases

• Diseases
  1 with human RARA associations

				Human Disease	Mouse Models
				acute promyelocytic leukemia IDs acute promyelocytic leukemia       DOID:0060318 ICD10CM:C92.4 MESH:D015473 NCI:C3182 OMIM:612376 ORDO:520 UMLS_CUI:C0023487

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  33 phenotypes from 5 alleles in 5 genetic backgrounds
  202 phenotypes from multigenic genotypes
  1 images
  88 phenotype references
  

• All Mutations and Alleles
  98
• Endonuclease-mediated
  2
• Gene trapped
  84
• Targeted
  12
• Genomic Mutations
  1 involving Rara
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  79 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygotes for targeted null mutations show high neonatal mortality due to maternal cannibalization, failure to thrive, and excess mortality during the postnatal period. Male survivors exhibit testicular degeneration.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  209
• GO References
  44

Expression

• Assay Results
  1507
• Tissues
  473
• cDNA Data
  62
• Literature Summary
  104

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase rara
  ZFIN raraa, rarab

Sequences &
Gene Models

• All Sequences
  78
• RefSeq
  20
• UniProt
  5
• CCDS
  CCDS36304.1, CCDS48905.1

• Ensembl
  ENSMUSG00000037992 (Evidence)
• NCBI Gene
  19401

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000037992	Ensembl Gene Model | MGI Sequence Detail	47125	C57BL/6J
transcript	ENSMUST00000107474	Ensembl | MGI Sequence Detail	2380	Not Applicable
polypeptide	ENSMUSP00000103098	Ensembl | MGI Sequence Detail	462	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000013736 retinoic acid receptor alpha
  (term hierarchy)
• InterPro Domains
  IPR001723 Nuclear hormone receptor
  IPR000536 Nuclear hormone receptor, ligand-binding domain
  IPR035500 Nuclear hormone receptor-like domain superfamily
  IPR003078 Retinoic acid receptor
  IPR047159 Retinoic acid receptor, DNA-binding domain
  IPR047158 Retinoic acid receptor, ligand-binding domain
  IPR013088 Zinc finger, NHR/GATA-type
  IPR001628 Zinc finger, nuclear hormone receptor-type

Molecular
Reagents

• All nucleic 113

  Genomic 5

  cDNA 72

  Primer pair 24

  Other 12

  
  

  Microarray probesets 3

Other
Accession IDs

MGD-MRK-13766

References

• Summaries
  All 369

  Developmental Gene Expression 104

  Gene Ontology 44

  Phenotypes 88
• Earliest
  J:9853 Harada M, et al., Strain difference and mode of inheritance of the susceptibility to passive cutaneous anaphylaxis mediated by allogeneic IgE antibody in the mouse. Immunol Invest. 1989 Jun;18(5):723-35
• Latest
  J:343286 Queen R, et al., Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves. PLoS Genet. 2023 Nov;19(11):e1010777

TSS for Rara:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104815	Chr11:98818611-98818636 (+)	-20 bp
Tssr3664	Chr11:98818640-98818650 (+)	1 bp
Tssr104816	Chr11:98818652-98818680 (+)	22 bp
Tssr104817	Chr11:98827979-98827996 (+)	9,344 bp
Tssr104818	Chr11:98828495-98828561 (+)	9,884 bp
Tssr104819	Chr11:98829202-98829213 (+)	10,564 bp
Tssr104820	Chr11:98830724-98830736 (+)	12,086 bp
Tssr104821	Chr11:98830740-98830770 (+)	12,111 bp
Tssr104822	Chr11:98833213-98833222 (+)	14,574 bp
Tssr104823	Chr11:98833313-98833325 (+)	14,675 bp
Tssr104824	Chr11:98834299-98834331 (+)	15,671 bp
Tssr104825	Chr11:98835025-98835069 (+)	16,403 bp
Tssr104826	Chr11:98835252-98835283 (+)	16,624 bp
Tssr104827	Chr11:98850582-98850597 (+)	31,946 bp
Tssr104828	Chr11:98850608-98850627 (+)	31,974 bp
Tssr104829	Chr11:98851261-98851311 (+)	32,642 bp
Tssr104830	Chr11:98851370-98851419 (+)	32,751 bp
Tssr104831	Chr11:98851429-98851446 (+)	32,794 bp
Tssr104832	Chr11:98851449-98851499 (+)	32,830 bp
Tssr104833	Chr11:98851559-98851584 (+)	32,928 bp
Tssr104834	Chr11:98851593-98851604 (+)	32,955 bp
Tssr104835	Chr11:98851605-98851616 (+)	32,967 bp
Tssr104836	Chr11:98855637-98855653 (+)	37,001 bp
Tssr104837	Chr11:98855690-98855709 (+)	37,056 bp
Tssr104838	Chr11:98855728-98855739 (+)	37,090 bp
Tssr104839	Chr11:98865414-98865429 (+)	46,778 bp

Rara is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bw4	Chr11, 50.86 cM		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 11, candidate genes for diabesity QTL Nidd4n (2 cM) are Dbn1 (34 cM- **Note: Location of Dbn1 is 34 cM on mouse Chromosome 13 according to mapping data in the MGI database**) and Dvl2 (36.5 cM). Both Dbn1 and Dvl2 show differential expression on the restricted and unrestricted diets on the A/A background. Candidate genes for diabesity QTLs Nidd1n (31 cM), Bwtq5 (27.8 cM), Wt10q3 (32 cM), Wt6q3 (36 cM) are Nola2 (28.5 cM, formerly Nhp2), Sept8 (28.75 cM), Skp1a (31 cM), and Mpdu1 (39 cM). Skp1a and Nola2 both show differential expression between restricted and unrestricted diets on the A/A background. Sept8 shows differential expression between A/a and A/A animals on the restricted diet. Candidate genes for diabesity QTLs Wg4 (46 cM) and Bw4 (55 cM) are Dusp14 (48 cM), Spag7 (42 cM), Derl2 (42 cM, formerly Flana), Sfrs1 (49 cM), and Rara (57.8 cM). Dusp14, Derl2, and Spag7 all show differential expression between A/a and A/A animals on the restricted diet. Sfrs1 shows differential expression between the restricted and unrestricted diets on the A/a background. Rara shows differential expression between the restricted and unrestricted diet on the A/a background as well as between A/a and A/A animals on the restricted diet. Fasn (72 cM) and Grb2 (75 cM) are candidate genes for diabesity QTL Nidd4 (68 cM). Fasn shows differential expression between restricted and unrestricted diets on the A/A background while Grb2 shows differential expression between A/a and A/A animals on the unrestricted diet.
Bwtq5	Chr11, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 11, candidate genes for diabesity QTL Nidd4n (2 cM) are Dbn1 (34 cM- **Note: Location of Dbn1 is 34 cM on mouse Chromosome 13 according to mapping data in the MGI database**) and Dvl2 (36.5 cM). Both Dbn1 and Dvl2 show differential expression on the restricted and unrestricted diets on the A/A background. Candidate genes for diabesity QTLs Nidd1n (31 cM), Bwtq5 (27.8 cM), Wt10q3 (32 cM), Wt6q3 (36 cM) are Nola2 (28.5 cM, formerly Nhp2), Sept8 (28.75 cM), Skp1a (31 cM), and Mpdu1 (39 cM). Skp1a and Nola2 both show differential expression between restricted and unrestricted diets on the A/A background. Sept8 shows differential expression between A/a and A/A animals on the restricted diet. Candidate genes for diabesity QTLs Wg4 (46 cM) and Bw4 (55 cM) are Dusp14 (48 cM), Spag7 (42 cM), Derl2 (42 cM, formerly Flana), Sfrs1 (49 cM), and Rara (57.8 cM). Dusp14, Derl2, and Spag7 all show differential expression between A/a and A/A animals on the restricted diet. Sfrs1 shows differential expression between the restricted and unrestricted diets on the A/a background. Rara shows differential expression between the restricted and unrestricted diet on the A/a background as well as between A/a and A/A animals on the restricted diet. Fasn (72 cM) and Grb2 (75 cM) are candidate genes for diabesity QTL Nidd4 (68 cM). Fasn shows differential expression between restricted and unrestricted diets on the A/A background while Grb2 shows differential expression between A/a and A/A animals on the unrestricted diet.
Nidd1n	Chr11, 33.94 cM	Chr11:45165873-79978324	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 11, candidate genes for diabesity QTL Nidd4n (2 cM) are Dbn1 (34 cM- **Note: Location of Dbn1 is 34 cM on mouse Chromosome 13 according to mapping data in the MGI database**) and Dvl2 (36.5 cM). Both Dbn1 and Dvl2 show differential expression on the restricted and unrestricted diets on the A/A background. Candidate genes for diabesity QTLs Nidd1n (31 cM), Bwtq5 (27.8 cM), Wt10q3 (32 cM), Wt6q3 (36 cM) are Nola2 (28.5 cM, formerly Nhp2), Sept8 (28.75 cM), Skp1a (31 cM), and Mpdu1 (39 cM). Skp1a and Nola2 both show differential expression between restricted and unrestricted diets on the A/A background. Sept8 shows differential expression between A/a and A/A animals on the restricted diet. Candidate genes for diabesity QTLs Wg4 (46 cM) and Bw4 (55 cM) are Dusp14 (48 cM), Spag7 (42 cM), Derl2 (42 cM, formerly Flana), Sfrs1 (49 cM), and Rara (57.8 cM). Dusp14, Derl2, and Spag7 all show differential expression between A/a and A/A animals on the restricted diet. Sfrs1 shows differential expression between the restricted and unrestricted diets on the A/a background. Rara shows differential expression between the restricted and unrestricted diet on the A/a background as well as between A/a and A/A animals on the restricted diet. Fasn (72 cM) and Grb2 (75 cM) are candidate genes for diabesity QTL Nidd4 (68 cM). Fasn shows differential expression between restricted and unrestricted diets on the A/A background while Grb2 shows differential expression between A/a and A/A animals on the unrestricted diet.
Nidd4	Chr11, 79.52 cM	Chr11:113810136-113810253	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 11, candidate genes for diabesity QTL Nidd4n (2 cM) are Dbn1 (34 cM- **Note: Location of Dbn1 is 34 cM on mouse Chromosome 13 according to mapping data in the MGI database**) and Dvl2 (36.5 cM). Both Dbn1 and Dvl2 show differential expression on the restricted and unrestricted diets on the A/A background. Candidate genes for diabesity QTLs Nidd1n (31 cM), Bwtq5 (27.8 cM), Wt10q3 (32 cM), Wt6q3 (36 cM) are Nola2 (28.5 cM, formerly Nhp2), Sept8 (28.75 cM), Skp1a (31 cM), and Mpdu1 (39 cM). Skp1a and Nola2 both show differential expression between restricted and unrestricted diets on the A/A background. Sept8 shows differential expression between A/a and A/A animals on the restricted diet. Candidate genes for diabesity QTLs Wg4 (46 cM) and Bw4 (55 cM) are Dusp14 (48 cM), Spag7 (42 cM), Derl2 (42 cM, formerly Flana), Sfrs1 (49 cM), and Rara (57.8 cM). Dusp14, Derl2, and Spag7 all show differential expression between A/a and A/A animals on the restricted diet. Sfrs1 shows differential expression between the restricted and unrestricted diets on the A/a background. Rara shows differential expression between the restricted and unrestricted diet on the A/a background as well as between A/a and A/A animals on the restricted diet. Fasn (72 cM) and Grb2 (75 cM) are candidate genes for diabesity QTL Nidd4 (68 cM). Fasn shows differential expression between restricted and unrestricted diets on the A/A background while Grb2 shows differential expression between A/a and A/A animals on the unrestricted diet.
Nidd4n	Chr11, 9.41 cM		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 11, candidate genes for diabesity QTL Nidd4n (2 cM) are Dbn1 (34 cM- **Note: Location of Dbn1 is 34 cM on mouse Chromosome 13 according to mapping data in the MGI database**) and Dvl2 (36.5 cM). Both Dbn1 and Dvl2 show differential expression on the restricted and unrestricted diets on the A/A background. Candidate genes for diabesity QTLs Nidd1n (31 cM), Bwtq5 (27.8 cM), Wt10q3 (32 cM), Wt6q3 (36 cM) are Nola2 (28.5 cM, formerly Nhp2), Sept8 (28.75 cM), Skp1a (31 cM), and Mpdu1 (39 cM). Skp1a and Nola2 both show differential expression between restricted and unrestricted diets on the A/A background. Sept8 shows differential expression between A/a and A/A animals on the restricted diet. Candidate genes for diabesity QTLs Wg4 (46 cM) and Bw4 (55 cM) are Dusp14 (48 cM), Spag7 (42 cM), Derl2 (42 cM, formerly Flana), Sfrs1 (49 cM), and Rara (57.8 cM). Dusp14, Derl2, and Spag7 all show differential expression between A/a and A/A animals on the restricted diet. Sfrs1 shows differential expression between the restricted and unrestricted diets on the A/a background. Rara shows differential expression between the restricted and unrestricted diet on the A/a background as well as between A/a and A/A animals on the restricted diet. Fasn (72 cM) and Grb2 (75 cM) are candidate genes for diabesity QTL Nidd4 (68 cM). Fasn shows differential expression between restricted and unrestricted diets on the A/A background while Grb2 shows differential expression between A/a and A/A animals on the unrestricted diet.
Wg4	Chr11, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 11, candidate genes for diabesity QTL Nidd4n (2 cM) are Dbn1 (34 cM- **Note: Location of Dbn1 is 34 cM on mouse Chromosome 13 according to mapping data in the MGI database**) and Dvl2 (36.5 cM). Both Dbn1 and Dvl2 show differential expression on the restricted and unrestricted diets on the A/A background. Candidate genes for diabesity QTLs Nidd1n (31 cM), Bwtq5 (27.8 cM), Wt10q3 (32 cM), Wt6q3 (36 cM) are Nola2 (28.5 cM, formerly Nhp2), Sept8 (28.75 cM), Skp1a (31 cM), and Mpdu1 (39 cM). Skp1a and Nola2 both show differential expression between restricted and unrestricted diets on the A/A background. Sept8 shows differential expression between A/a and A/A animals on the restricted diet. Candidate genes for diabesity QTLs Wg4 (46 cM) and Bw4 (55 cM) are Dusp14 (48 cM), Spag7 (42 cM), Derl2 (42 cM, formerly Flana), Sfrs1 (49 cM), and Rara (57.8 cM). Dusp14, Derl2, and Spag7 all show differential expression between A/a and A/A animals on the restricted diet. Sfrs1 shows differential expression between the restricted and unrestricted diets on the A/a background. Rara shows differential expression between the restricted and unrestricted diet on the A/a background as well as between A/a and A/A animals on the restricted diet. Fasn (72 cM) and Grb2 (75 cM) are candidate genes for diabesity QTL Nidd4 (68 cM). Fasn shows differential expression between restricted and unrestricted diets on the A/A background while Grb2 shows differential expression between A/a and A/A animals on the unrestricted diet.
Wt6q3	Chr11, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 11, candidate genes for diabesity QTL Nidd4n (2 cM) are Dbn1 (34 cM- **Note: Location of Dbn1 is 34 cM on mouse Chromosome 13 according to mapping data in the MGI database**) and Dvl2 (36.5 cM). Both Dbn1 and Dvl2 show differential expression on the restricted and unrestricted diets on the A/A background. Candidate genes for diabesity QTLs Nidd1n (31 cM), Bwtq5 (27.8 cM), Wt10q3 (32 cM), Wt6q3 (36 cM) are Nola2 (28.5 cM, formerly Nhp2), Sept8 (28.75 cM), Skp1a (31 cM), and Mpdu1 (39 cM). Skp1a and Nola2 both show differential expression between restricted and unrestricted diets on the A/A background. Sept8 shows differential expression between A/a and A/A animals on the restricted diet. Candidate genes for diabesity QTLs Wg4 (46 cM) and Bw4 (55 cM) are Dusp14 (48 cM), Spag7 (42 cM), Derl2 (42 cM, formerly Flana), Sfrs1 (49 cM), and Rara (57.8 cM). Dusp14, Derl2, and Spag7 all show differential expression between A/a and A/A animals on the restricted diet. Sfrs1 shows differential expression between the restricted and unrestricted diets on the A/a background. Rara shows differential expression between the restricted and unrestricted diet on the A/a background as well as between A/a and A/A animals on the restricted diet. Fasn (72 cM) and Grb2 (75 cM) are candidate genes for diabesity QTL Nidd4 (68 cM). Fasn shows differential expression between restricted and unrestricted diets on the A/A background while Grb2 shows differential expression between A/a and A/A animals on the unrestricted diet.
Wt10q3	Chr11, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 11, candidate genes for diabesity QTL Nidd4n (2 cM) are Dbn1 (34 cM- **Note: Location of Dbn1 is 34 cM on mouse Chromosome 13 according to mapping data in the MGI database**) and Dvl2 (36.5 cM). Both Dbn1 and Dvl2 show differential expression on the restricted and unrestricted diets on the A/A background. Candidate genes for diabesity QTLs Nidd1n (31 cM), Bwtq5 (27.8 cM), Wt10q3 (32 cM), Wt6q3 (36 cM) are Nola2 (28.5 cM, formerly Nhp2), Sept8 (28.75 cM), Skp1a (31 cM), and Mpdu1 (39 cM). Skp1a and Nola2 both show differential expression between restricted and unrestricted diets on the A/A background. Sept8 shows differential expression between A/a and A/A animals on the restricted diet. Candidate genes for diabesity QTLs Wg4 (46 cM) and Bw4 (55 cM) are Dusp14 (48 cM), Spag7 (42 cM), Derl2 (42 cM, formerly Flana), Sfrs1 (49 cM), and Rara (57.8 cM). Dusp14, Derl2, and Spag7 all show differential expression between A/a and A/A animals on the restricted diet. Sfrs1 shows differential expression between the restricted and unrestricted diets on the A/a background. Rara shows differential expression between the restricted and unrestricted diet on the A/a background as well as between A/a and A/A animals on the restricted diet. Fasn (72 cM) and Grb2 (75 cM) are candidate genes for diabesity QTL Nidd4 (68 cM). Fasn shows differential expression between restricted and unrestricted diets on the A/A background while Grb2 shows differential expression between A/a and A/A animals on the unrestricted diet.

*cM position of peak correlated region/marker