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Rasa1 Gene Detail
Summary
  • Symbol
    Rasa1
  • Name
    RAS p21 protein activator 1
  • Synonyms
    Gap, MGC:7759, p120-rasGAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:97860
    NCBI Gene: 218397
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:85362899-85437249 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 45.05 cM
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1815 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97860
 protein coding gene Chr13:85362893-85437487 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020796
 protein coding gene Chr13:86142103-86219998 (-)
A/J MGP_AJ_G0020750
 protein coding gene Chr13:83102828-83177823 (-)
AKR/J MGP_AKRJ_G0020723
 protein coding gene Chr13:85540663-85620645 (-)
BALB/cJ MGP_BALBcJ_G0020746
 protein coding gene Chr13:83657840-83735248 (-)
C3H/HeJ MGP_C3HHeJ_G0020540
 protein coding gene Chr13:85238280-85313661 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021183
 protein coding gene Chr13:88866702-88952250 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018751
 protein coding gene Chr13:79410035-79488153 (-)
CAST/EiJ MGP_CASTEiJ_G0020058
 protein coding gene Chr13:84399703-84485298 (-)
CBA/J MGP_CBAJ_G0020499
 protein coding gene Chr13:92212045-92294562 (-)
DBA/2J MGP_DBA2J_G0020624
 protein coding gene Chr13:82727562-82803796 (-)
FVB/NJ MGP_FVBNJ_G0020604
 protein coding gene Chr13:81766043-81840931 (-)
LP/J MGP_LPJ_G0020697
 protein coding gene Chr13:86350300-86437616 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020633
 protein coding gene Chr13:91572851-91687970 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021223
 protein coding gene Chr13:84944307-85023539 (-)
PWK/PhJ MGP_PWKPhJ_G0019811
 protein coding gene Chr13:81629597-81711279 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019634
 protein coding gene Chr13:81289676-81371581 (-)
WSB/EiJ MGP_WSBEiJ_G0020116
 protein coding gene Chr13:85429855-85509073 (-)



Homology
more
  • Human Ortholog
    RASA1, RAS p21 protein activator 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASA1, RAS p21 protein activator 1
  • Synonyms
    CM-AVM, CMAVM, CMAVM1, GAP, p120, p120GAP, p120RASGAP, PKWS, RASA, RASGAP
  • Links
    NCBI Gene ID: 5921
    neXtProt AC: NX_P20936
    UniProt: P20936

  • Chr Location
    5q14.3; chr5:87267883-87391931 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human RASA1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 4 alleles in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced embryonic growth associated with defects of both yolk sac and embryonic vascular systems resulting in lethality by embryonic day 10.5. Mice homozygous for a knock-in allele exhibit increased sensitivity to induced cell death and colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    49
  • cDNA Data
    117
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021549 Ensembl Gene Model | MGI Sequence Detail 74351 C57BL/6J ±  kb
    transcript ENSMUST00000109552 Ensembl | MGI Sequence Detail 4563 Not Applicable  
    polypeptide ENSMUSP00000105179 Ensembl | MGI Sequence Detail 1038 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 124
      Genomic 2
      cDNA 120
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-13770, MGD-MRK-9965
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 25
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory