Rbp1 MGI Mouse Gene Detail - MGI:97876 - retinol binding protein 1, cellular

Symbol

Rbp1
Name

retinol binding protein 1, cellular
Synonyms

Crbp, CRBPI, Rbp-1

Feature Type

protein coding gene
IDs

MGI:97876
NCBI Gene: 19659
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:98305014-98328604 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 51.36 cM
Mapping Data

11 experiments

SNPs within 2kb

826 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97876	protein coding gene	Chr9:98305014-98328628 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035154	protein coding gene	Chr9:99724425-99751750 (+)
A/J	MGP_AJ_G0035136	protein coding gene	Chr9:96220623-96244183 (+)
AKR/J	MGP_AKRJ_G0035067	protein coding gene	Chr9:98566488-98591424 (+)
BALB/cJ	MGP_BALBcJ_G0035128	protein coding gene	Chr9:95901538-95925957 (+)
C3H/HeJ	MGP_C3HHeJ_G0034838	protein coding gene	Chr9:98964659-98990232 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035648	protein coding gene	Chr9:102565788-102592295 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032547	protein coding gene	Chr9:93993254-94016533 (+)
CAST/EiJ	MGP_CASTEiJ_G0034149	protein coding gene	Chr9:98770991-98794841 (+)
CBA/J	MGP_CBAJ_G0034806	protein coding gene	Chr9:106106795-106136924 (+)
DBA/2J	MGP_DBA2J_G0034968	protein coding gene	Chr9:95735369-95759493 (+)
FVB/NJ	MGP_FVBNJ_G0034916	protein coding gene	Chr9:94566447-94590519 (+)
LP/J	MGP_LPJ_G0035047	protein coding gene	Chr9:99976595-100002945 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034955	protein coding gene	Chr9:108053835-108078711 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035670	protein coding gene	Chr9:98789829-98814652 (+)
PWK/PhJ	MGP_PWKPhJ_G0033856	protein coding gene	Chr9:95937167-95961119 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033692	protein coding gene	Chr9:98851017-98877411 (+)
WSB/EiJ	MGP_WSBEiJ_G0034269	protein coding gene	Chr9:98674345-98699808 (+)

Human Ortholog

RBP1, retinol binding protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBP1, retinol binding protein 1
Synonyms

CRABP-I, CRBP, CRBP1, CRBPI, hCRBP1, RBPC
Links

HGNC:9919

NCBI Gene ID: 5947

neXtProt AC: NX_P09455

UniProt: P09455
Chr Location

3q23; chr3:139517434-139539829 (-) GRCh38

MGI Vertebrate Homology

Rbp1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RBP1
Gene Tree

Rbp1

Diseases

1 with human RBP1 associations

				Human Disease	Mouse Models
				multiple myeloma IDs multiple myeloma DOID:9538 EFO:0001378 ICD10CM:C90.0 ICD9CM:203.0 MESH:D009101 NCI:C3242 OMIM:254500 ORDO:29073 UMLS_CUI:C0026764

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

19 phenotypes from 2 alleles in 3 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Rbp1
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation show increased susceptibility to a diet deficient in vitamin A. Mutants also exhibit a two-fold delay in dark adaptation after a photic flash.

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All GO Annotations

37
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1173
Tissues

280
cDNA Data

90
Literature Summary

60

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RBP1

Xenbase rbp1

ZFIN rbp1.1

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS23424.1

Ensembl

ENSMUSG00000046402 (Evidence)
NCBI Gene

19659

			Length	Strain/Species	Flank
genomic	19659	NCBI Gene Model \| MGI Sequence Detail	23591	C57BL/6J	± kb
transcript	NM_011254	RefSeq \| MGI Sequence Detail	2628	ZRU/MplStud
polypeptide	Q00915	UniProt \| EBI \| MGI Sequence Detail	135	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013818 retinol-binding protein 1

(term hierarchy)
InterPro Domains

IPR012674 Calycin

IPR000463 Cytosolic fatty-acid binding

IPR031259 Intracellular lipid binding protein

IPR000566 Lipocalin/cytosolic fatty-acid binding domain

IPR031264 Retinol-binding protein 1

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All nucleic 106

Genomic 2

cDNA 97

Primer pair 6

Other 1

Microarray probesets 5

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MGD-MRK-13787, MGD-MRK-13792, MGD-MRK-2131

Summaries

All 126

Developmental Gene Expression 60

Gene Ontology 13

Phenotypes 25
Earliest

J:8604 Demmer LA, et al., The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene. J Biol Chem. 1987 Feb 25;262(6):2458-67
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86646	Chr9:98306832-98306885 (+)	1,845 bp
Tssr86647	Chr9:98306915-98306958 (+)	1,923 bp
Tssr86648	Chr9:98306975-98306988 (+)	1,968 bp
Tssr86649	Chr9:98307012-98307023 (+)	2,004 bp
Tssr2984	Chr9:98307136-98307157 (+)	2,133 bp
Tssr86650	Chr9:98307359-98307383 (+)	2,357 bp
Tssr86651	Chr9:98307541-98307566 (+)	2,540 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24