Rbp3 MGI Mouse Gene Detail - MGI:97878 - retinol binding protein 3, interstitial

Symbol

Rbp3
Name

retinol binding protein 3, interstitial
Synonyms

Irbp, Rbp-3

Feature Type

protein coding gene
IDs

MGI:97878
NCBI Gene: 19661
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:33675960-33686173 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 20.80 cM
Mapping Data

8 experiments

SNPs within 2kb

397 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97878	protein coding gene	Chr14:33675960-33686176 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021161	protein coding gene	Chr14:27286446-27296509 (+)
A/J	MGP_AJ_G0021109	protein coding gene	Chr14:26231400-26241463 (+)
AKR/J	MGP_AKRJ_G0021086	protein coding gene	Chr14:27399693-27409810 (+)
BALB/cJ	MGP_BALBcJ_G0021113	protein coding gene	Chr14:26415504-26425646 (+)
C3H/HeJ	MGP_C3HHeJ_G0020896	protein coding gene	Chr14:27316011-27326153 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021545	protein coding gene	Chr14:28334988-28345077 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019107	protein coding gene	Chr14:26269292-26279277 (+)
CAST/EiJ	MGP_CASTEiJ_G0020421	protein coding gene	Chr14:27131580-27141903 (+)
CBA/J	MGP_CBAJ_G0020863	protein coding gene	Chr14:29368484-29378626 (+)
DBA/2J	MGP_DBA2J_G0020985	protein coding gene	Chr14:26269154-26279296 (+)
FVB/NJ	MGP_FVBNJ_G0020969	protein coding gene	Chr14:26223120-26233236 (+)
LP/J	MGP_LPJ_G0021054	protein coding gene	Chr14:27623522-27633663 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020995	protein coding gene	Chr14:28525061-28535175 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021578	protein coding gene	Chr14:27225531-27235673 (+)
PWK/PhJ	MGP_PWKPhJ_G0020169	protein coding gene	Chr14:25759950-25770091 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019993	protein coding gene	Chr14:26844356-26854436 (+)
WSB/EiJ	MGP_WSBEiJ_G0020476	protein coding gene	Chr14:27289485-27299625 (+)

Human Ortholog

RBP3, retinol binding protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBP3, retinol binding protein 3
Synonyms

D10S64, D10S65, D10S66, IRBP, RBPI, RP66
Links

HGNC:9921

NCBI Gene ID: 5949

neXtProt AC: NX_P10745

UniProt: P10745
Chr Location

10q11.22; chr10:47348363-47357881 (+) GRCh38

MGI Vertebrate Homology

Rbp3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RBP3
Gene Tree

Rbp3

Diseases

1 with human RBP3 associations

				Human Disease	Mouse Models
				retinitis pigmentosa 66 IDs retinitis pigmentosa 66 DOID:0110393 ICD10CM:H35.5 OMIM:615233

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

90 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for disruptions in this gene experience photoreceptor degeneration.

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All GO Annotations

10
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

758
Tissues

25
cDNA Data

123
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RBP3

Xenbase rbp3

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS26929.1

Ensembl

ENSMUSG00000041534 (Evidence)
NCBI Gene

19661

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041534	Ensembl Gene Model \| MGI Sequence Detail	10214	C57BL/6J	± kb
transcript	ENSMUST00000035695	Ensembl \| MGI Sequence Detail	5295	Not Applicable
polypeptide	ENSMUSP00000040249	Ensembl \| MGI Sequence Detail	1234	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013820 retinol-binding protein 3

(term hierarchy)
InterPro Domains

IPR029045 ClpP/crotonase-like domain superfamily

IPR005151 Tail specific protease
GlyGen

P49194 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 135

Genomic 5

cDNA 128

Primer pair 1

Other 1

Microarray probesets 2

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MGD-MRK-11462, MGD-MRK-13789, MGD-MRK-13794

Summaries

All 76

Developmental Gene Expression 8

Gene Ontology 6

Phenotypes 28
Earliest

J:12496 Kozak C, et al., Chromosome assignment in the mouse of the genes for several proteins involved in visual transduction. Cytogenet Cell Genet. 1989;51:1025-1026 (Abstr.)
Latest

J:353299 Getz TE, et al., Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia. Invest Ophthalmol Vis Sci. 2024 Jun 3;65(6):32

TSS for Rbp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125053	Chr14:33675934-33675973 (+)	-6 bp
Tssr125054	Chr14:33675977-33675988 (+)	23 bp
Tssr125055	Chr14:33675997-33676016 (+)	47 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24