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Rad51 Gene Detail
Summary
  • Symbol
    Rad51
  • Name
    RAD51 recombinase
  • Synonyms
    Rad51a, Reca
  • Feature Type
    protein coding gene
  • IDs
    MGI:97890
    NCBI Gene: 19361
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:118943295-118966554 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.92 cM, cytoband F1
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    538 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97890
 protein coding gene Chr2:118943274-118977926 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026331
 protein coding gene Chr2:121846411-121881244 (+)
A/J MGP_AJ_G0026292
 protein coding gene Chr2:116887168-116921039 (+)
AKR/J MGP_AKRJ_G0026271
 protein coding gene Chr2:120157776-120192739 (+)
BALB/cJ MGP_BALBcJ_G0026305
 protein coding gene Chr2:117151390-117184262 (+)
C3H/HeJ MGP_C3HHeJ_G0026051
 protein coding gene Chr2:120629404-120663252 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026752
 protein coding gene Chr2:125847502-125883005 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024132
 protein coding gene Chr2:111941193-111964161 (+)
CAST/EiJ MGP_CASTEiJ_G0025513
 protein coding gene Chr2:120932159-120966459 (+)
CBA/J MGP_CBAJ_G0026027
 protein coding gene Chr2:130279374-130318225 (+)
DBA/2J MGP_DBA2J_G0026166
 protein coding gene Chr2:116316233-116348945 (+)
FVB/NJ MGP_FVBNJ_G0026128
 protein coding gene Chr2:115134287-115167240 (+)
LP/J MGP_LPJ_G0026267
 protein coding gene Chr2:122161337-122194703 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026147
 protein coding gene Chr2:134644046-134681261 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026807
 protein coding gene Chr2:120283030-120317469 (+)
PWK/PhJ MGP_PWKPhJ_G0025249
 protein coding gene Chr2:115867985-115903155 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025048
 protein coding gene Chr2:119467291-119503263 (+)
WSB/EiJ MGP_WSBEiJ_G0025582
 protein coding gene Chr2:121112070-121146046 (+)



Homology
more
  • Human Ortholog
    RAD51, RAD51 recombinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAD51, RAD51 recombinase
  • Synonyms
    BRCC5, FANCR, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA
  • Links
    NCBI Gene ID: 5888
    neXtProt AC: NX_Q06609
    UniProt: Q06609

  • Chr Location
    15q15.1; chr15:40694733-40732340 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human RAD51 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die prior to implantation, usually by the eight-cell stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    125
  • GO References
    49
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    907
  • Tissues
    57
  • cDNA Data
    80
  • Literature Summary
    75
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19361 NCBI Gene Model | MGI Sequence Detail 23260 C57BL/6J ±  kb
    transcript NM_011234 RefSeq | MGI Sequence Detail 2144 ZRU/MplStud  
    polypeptide Q08297 UniProt | EBI | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013672 DNA repair protein RAD51 homolog 1
      (term hierarchy)
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR013632 DNA recombination and repair protein Rad51-like, C-terminal
      IPR016467 DNA recombination and repair protein, RecA-like
      IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
      IPR020587 DNA recombination and repair protein RecA, monomer-monomer interface
      IPR011941 DNA recombination/repair protein Rad51
      IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 98
      Genomic 9
      cDNA 81
      Primer pair 7
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13824, MGI:2139265
    References
    more
    • Summaries
      All 190
      Developmental Gene Expression 75
      Gene Ontology 49
      Phenotypes 16
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:346053 Zhang J, et al., Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2. Nat Commun. 2024 Mar 14;15(1):2315
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory