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Ret Gene Detail
Summary
  • Symbol
    Ret
  • Name
    ret proto-oncogene
  • Synonyms
    c-Ret, RET51, RET9
Location &
Maps
more
  • Sequence Map
    Chr6:118128706-118174679 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 55.86 cM, cytoband E3-F1
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1384 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97902
 protein coding gene Chr6:118128706-118174705 (-)
129S1/SvImJ ENSMUSG00200050457
 protein coding gene Chr6:115336613-115382575 (-)
A/J ENSMUSG00195044291
 protein coding gene Chr6:114736729-114782710 (-)
AKR/J ENSMUSG00220027153
 protein coding gene Chr6:113622699-113668672 (-)
BALB/cJ ENSMUSG00180037868
 protein coding gene Chr6:115104414-115150398 (-)
C3H/HeJ ENSMUSG00175028776
 protein coding gene Chr6:62319696-62365673 (+)
C57BL/6NJ ENSMUSG00215045159
 protein coding gene Chr6:115094568-115140549 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028784
 protein coding gene Chr6:113194916-113240621 (-)
CAST/EiJ ENSTCUG00005046158
 protein coding gene Chr6:114902473-114948227 (-)
CBA/J ENSMUSG00210038569
 protein coding gene Chr6:114871685-114917662 (-)
DBA/2J ENSMUSG00185045564
 protein coding gene Chr6:115534714-115580678 (-)
FVB/NJ ENSMUSG00205030896
 protein coding gene Chr6:113984688-114030496 (-)
JF1/MsJ ENSUMUG00000045844
 protein coding gene Chr6:114125312-114170982 (-)
LP/J ENSMUSG00230047151
 protein coding gene Chr6:116734116-116780079 (-)
NOD/ShiLtJ ENSMUSG00190047047
 protein coding gene Chr6:114488767-114534729 (-)
NZO/HlLtJ ENSMUSG00225044614
 protein coding gene Chr6:118589932-118635905 (-)
PWK/PhJ ENSLUMG00010043259
 protein coding gene Chr6:113486489-113532213 (-)
SPRET/EiJ ENSMSPG00010040147
 protein coding gene Chr6:116340306-116386152 (-)
WSB/EiJ ENSIUOG00005038907
 protein coding gene Chr6:115161989-115207905 (-)



Homology
more
  • Human Ortholog
    RET, ret proto-oncogene
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RET, ret proto-oncogene
  • Synonyms
    CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1
  • Links
    NCBI Gene ID: 5979
    UniProt: P07949

  • Chr Location
    10q11.21; chr10:43077026-43130351 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with Ret mouse models; 6 with human RET associations

Human Disease Mouse Models
      
IDs
 View 4 models
IDs
 View 2 models
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
 View 2 "NOT" models
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    125 phenotypes from 32 alleles in 33 genetic backgrounds
    42 phenotypes from multigenic genotypes
    246 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for some point mutations or knock-out alleles exhibit premature lethality, defects in neurogenesis, and abnormal kidney, ureter, ovary, muscle, and intestine morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    105
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2058
  • Tissues
    509
  • cDNA Data
    49
  • Literature Summary
    441
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030110 Ensembl Gene Model | MGI Sequence Detail 45974 C57BL/6J ±  kb
    transcript ENSMUST00000032201 Ensembl | MGI Sequence Detail 5456 Not Applicable  
    polypeptide ENSMUSP00000032201 Ensembl | MGI Sequence Detail 1115 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      Genomic 2
      cDNA 57
      Primer pair 32
      Other 49
      Antibodies 16

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13846
    References
    more
    • Summaries
      All 780
      Developmental Gene Expression 441
      Diseases 6
      Gene Ontology 33
      Phenotypes 246
    • Earliest
      J:10540 Takahashi M, et al., Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene. 1988 Nov;3(5):571-8
    • Latest
      J:390120 Trowe MO, et al., Mesenchymal WNT signaling coordinates epithelial and mesenchymal differentiation in the developing murine ureter. Cell Commun Signal. 2026 Jul 21;24(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory